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Aliases for TMCO5A Gene

Aliases for TMCO5A Gene

  • Transmembrane And Coiled-Coil Domains 5A 2 3 5
  • Transmembrane And Coiled-Coil Domains 5 2 3
  • TMCO5 3 4
  • Transmembrane And Coiled-Coil Domain-Containing Protein 5A 3
  • Testicular Tissue Protein Li 205 3

External Ids for TMCO5A Gene

Previous HGNC Symbols for TMCO5A Gene

  • TMCO5

Previous GeneCards Identifiers for TMCO5A Gene

  • GC15P036016
  • GC15P038227
  • GC15P015072

Summaries for TMCO5A Gene

GeneCards Summary for TMCO5A Gene

TMCO5A (Transmembrane And Coiled-Coil Domains 5A) is a Protein Coding gene. Diseases associated with TMCO5A include Spastic Paraplegia 11, Autosomal Recessive.

Additional gene information for TMCO5A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCO5A Gene

Genomics for TMCO5A Gene

GeneHancer (GH) Regulatory Elements for TMCO5A Gene

Promoters and enhancers for TMCO5A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J037921 Enhancer 0.3 ENCODE 650.7 -0.3 -259 1 NFE2 TMCO5A GC15P037868
GH15J037585 Enhancer 0.2 FANTOM5 3.7 -336.1 -336110 0.1 TMCO5A GC15P037592 LOC105370772
GH15J037899 Enhancer 0.7 Ensembl ENCODE 0.3 -21.1 -21108 1.9 JUND JUN FOSL2 FOS TMCO5A GC15P037868
GH15J037880 Enhancer 0.7 UCNEbase 0.3 -41.5 -41464 0.5 MEIS2 CTCF ZNF654 POLR2A SMC3 REST RAD21 GC15P037868 TMCO5A
GH15J037879 Enhancer 0.6 UCNEbase 0.3 -41.9 -41902 0.2 MEIS2 POLR2A GC15P037868 TMCO5A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMCO5A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMCO5A gene promoter:
  • AREB6
  • C/EBPalpha
  • MyoD
  • Pax-6
  • RSRFC4
  • RelA
  • HOXA3
  • CUTL1
  • POU3F2
  • POU3F2 (N-Oct-5a)

Genomic Locations for TMCO5A Gene

Genomic Locations for TMCO5A Gene
73,095 bases
Plus strand
45,786 bases
Plus strand

Genomic View for TMCO5A Gene

Genes around TMCO5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMCO5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMCO5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCO5A Gene

Proteins for TMCO5A Gene

  • Protein details for TMCO5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and coiled-coil domain-containing protein 5A
    Protein Accession:
    Secondary Accessions:
    • Q8NA63

    Protein attributes for TMCO5A Gene

    288 amino acids
    Molecular mass:
    34174 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMCO5A Gene


neXtProt entry for TMCO5A Gene

Post-translational modifications for TMCO5A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMCO5A Gene

Domains & Families for TMCO5A Gene

Gene Families for TMCO5A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMCO5A Gene


Suggested Antigen Peptide Sequences for TMCO5A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMCO5 family.
  • Belongs to the TMCO5 family.
genes like me logo Genes that share domains with TMCO5A: view

Function for TMCO5A Gene

Phenotypes From GWAS Catalog for TMCO5A Gene

genes like me logo Genes that share phenotypes with TMCO5A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMCO5A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMCO5A Gene

Localization for TMCO5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCO5A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMCO5A gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMCO5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCO5A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMCO5A Gene

Pathways & Interactions for TMCO5A Gene

SuperPathways for TMCO5A Gene

No Data Available

Interacting Proteins for TMCO5A Gene

Gene Ontology (GO) - Biological Process for TMCO5A Gene


No data available for Pathways by source and SIGNOR curated interactions for TMCO5A Gene

Drugs & Compounds for TMCO5A Gene

No Compound Related Data Available

Transcripts for TMCO5A Gene

mRNA/cDNA for TMCO5A Gene

Unigene Clusters for TMCO5A Gene

Transmembrane and coiled-coil domains 5A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMCO5A

Alternative Splicing Database (ASD) splice patterns (SP) for TMCO5A Gene

No ASD Table

Relevant External Links for TMCO5A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMCO5A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMCO5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMCO5A Gene

This gene is overexpressed in Testis (x52.4).

Protein differential expression in normal tissues from HIPED for TMCO5A Gene

This gene is overexpressed in Testis (41.3), Platelet (14.1), and Heart (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMCO5A Gene

Protein tissue co-expression partners for TMCO5A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMCO5A Gene:


SOURCE GeneReport for Unigene cluster for TMCO5A Gene:


Evidence on tissue expression from TISSUES for TMCO5A Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMCO5A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMCO5A Gene

Orthologs for TMCO5A Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMCO5A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMCO5A 34 33
  • 97.76 (n)
(Canis familiaris)
Mammalia TMCO5A 34 33
  • 84.49 (n)
(Rattus norvegicus)
Mammalia Tmco5a 33
  • 78.47 (n)
(Mus musculus)
Mammalia Tmco5 16 34 33
  • 77.66 (n)
(Bos Taurus)
Mammalia TMCO5A 34
  • 71 (a)
(Monodelphis domestica)
Mammalia TMCO5A 34
  • 35 (a)
Species where no ortholog for TMCO5A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMCO5A Gene

Gene Tree for TMCO5A (if available)
Gene Tree for TMCO5A (if available)
Evolutionary constrained regions (ECRs) for TMCO5A: view image

Paralogs for TMCO5A Gene

(1) SIMAP similar genes for TMCO5A Gene using alignment to 7 proteins:

  • F5H0U8_HUMAN
  • H0YL40_HUMAN
  • H0YMD4_HUMAN Pseudogenes for TMCO5A Gene

genes like me logo Genes that share paralogs with TMCO5A: view

No data available for Paralogs for TMCO5A Gene

Variants for TMCO5A Gene

Sequence variations from dbSNP and Humsavar for TMCO5A Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs193920912 uncertain-significance, Malignant tumor of prostate 37,947,673(+) G/A/C coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, synonymous_variant
rs1000053992 -- 37,961,568(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000081242 -- 37,955,745(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000119165 -- 37,960,185(+) T/ genic_downstream_transcript_variant, intron_variant
rs1000192168 -- 37,994,520(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMCO5A Gene

Variant ID Type Subtype PubMed ID
esv3892674 CNV gain 25118596

Variation tolerance for TMCO5A Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMCO5A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMCO5A Gene

Disorders for TMCO5A Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMCO5A Gene - From: DISEASES

Disorder Aliases PubMed IDs
spastic paraplegia 11, autosomal recessive
  • spg11
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMCO5A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TMCO5A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMCO5A Gene

Publications for TMCO5A Gene

  1. Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray. (PMID: 19679847) Lanktree MB … Anand SS (Stroke 2009) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Progression-free survival in ovarian cancer is reflected in epigenetic DNA methylation profiles. (PMID: 21577013) Bauerschlag DO … Wagner W (Oncology 2011) 3 58
  5. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. (PMID: 18711365) Ferreira MA … Wellcome Trust Case Control Consortium (Nature genetics 2008) 44 58

Products for TMCO5A Gene

Sources for TMCO5A Gene

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