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Aliases for SLC2A14 Gene

Aliases for SLC2A14 Gene

  • Solute Carrier Family 2 Member 14 2 3 5
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 3 Pseudogene 3 2 3
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 14 2 3
  • Glucose Transporter Type 14 3 4
  • GLUT14 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 14 3
  • SLC2A3P3 3
  • GLUT-14 4
  • GLUT3 4

External Ids for SLC2A14 Gene

Previous HGNC Symbols for SLC2A14 Gene

  • SLC2A3P3

Previous GeneCards Identifiers for SLC2A14 Gene

  • GC00U900937
  • GC12M007865
  • GC12M007857
  • GC12M007856
  • GC12M007965

Summaries for SLC2A14 Gene

Entrez Gene Summary for SLC2A14 Gene

  • Members of the glucose transporter (GLUT) family, including SLC2A14, are highly conserved integral membrane proteins that transport hexoses such as glucose and fructose into all mammalian cells. GLUTs show tissue and cell-type specific expression (Wu and Freeze, 2002 [PubMed 12504846]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC2A14 Gene

SLC2A14 (Solute Carrier Family 2 Member 14) is a Protein Coding gene. Diseases associated with SLC2A14 include Early Onset Absence Epilepsy and Xanthogranulomatous Cholecystitis. Among its related pathways are Metabolism and PAK Pathway. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A3.

UniProtKB/Swiss-Prot for SLC2A14 Gene

  • Facilitative glucose transporter (By similarity). May have a specific function related to spermatogenesis.

Gene Wiki entry for SLC2A14 Gene

Additional gene information for SLC2A14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A14 Gene

Genomics for SLC2A14 Gene

GeneHancer (GH) Regulatory Elements for SLC2A14 Gene

Promoters and enhancers for SLC2A14 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J007890 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 672.3 -0.3 -303 2.8 FOXA2 ARID4B DMAP1 ZNF48 ETS1 YY1 FOS ATF7 RXRA MIER2 SLC2A14 NANOGP1 FOXJ2 ENSG00000255356 GC12M007881
GH12J007872 Promoter 0.5 EPDnew 650.4 +18.4 18413 0.1 LOC100130582 SLC2A14 GC12M007885
GH12J007873 Promoter 0.5 EPDnew 650.4 +18.0 18003 0.1 SLC2A14 LOC100130582 GC12M007885
GH12J007831 Promoter 0.5 EPDnew 650.2 +59.5 59524 0.1 SLC2A14 DPPA3 ENSG00000201663 GC12M007850 GC12P007808
GH12J007933 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 20.8 -43.9 -43909 4.8 PKNOX1 ATF1 SMAD1 ARID4B SIN3A ZNF2 IRF4 NCOA2 YY1 ZNF121 SLC2A3 SLC2A14 POU5F1P3 ENSG00000256967 GC12M007881
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC2A14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC2A14 gene promoter:
  • COMP1
  • FOXD3
  • AREB6
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • E2F
  • E2F-1
  • E2F-2

Genomic Locations for SLC2A14 Gene

Genomic Locations for SLC2A14 Gene
78,685 bases
Minus strand
78,637 bases
Minus strand

Genomic View for SLC2A14 Gene

Genes around SLC2A14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A14 Gene

Proteins for SLC2A14 Gene

  • Protein details for SLC2A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 14
    Protein Accession:
    Secondary Accessions:
    • B3KVB5
    • B3KWW7
    • B7Z844
    • B7ZAC3
    • Q6UY84
    • Q8TDB9

    Protein attributes for SLC2A14 Gene

    520 amino acids
    Molecular mass:
    56320 Da
    Quaternary structure:
    No Data Available
    • GLUT14 is a recent (less than 5 M year old) duplication of GLUT3.

    Alternative splice isoforms for SLC2A14 Gene


neXtProt entry for SLC2A14 Gene

Post-translational modifications for SLC2A14 Gene

  • Glycosylation at isoforms=2, 567
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC2A14 Gene

Domains & Families for SLC2A14 Gene

Gene Families for SLC2A14 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A14: view

Function for SLC2A14 Gene

Molecular function for SLC2A14 Gene

UniProtKB/Swiss-Prot Function:
Facilitative glucose transporter (By similarity). May have a specific function related to spermatogenesis.

Gene Ontology (GO) - Molecular Function for SLC2A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005355 glucose transmembrane transporter activity IEA --
GO:0022857 transmembrane transporter activity IEA --
GO:0055056 D-glucose transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC2A14: view
genes like me logo Genes that share phenotypes with SLC2A14: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC2A14 Gene

Localization for SLC2A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A14 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC2A14 gene
Compartment Confidence
plasma membrane 5
nucleus 5
mitochondrion 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC2A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC2A14: view

Pathways & Interactions for SLC2A14 Gene

genes like me logo Genes that share pathways with SLC2A14: view

Pathways by source for SLC2A14 Gene

1 Qiagen pathway for SLC2A14 Gene

Gene Ontology (GO) - Biological Process for SLC2A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0008643 carbohydrate transport IEA --
GO:0030154 cell differentiation IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC2A14: view

No data available for SIGNOR curated interactions for SLC2A14 Gene

Drugs & Compounds for SLC2A14 Gene

No Compound Related Data Available

Transcripts for SLC2A14 Gene

Unigene Clusters for SLC2A14 Gene

Solute carrier family 2 (facilitated glucose transporter), member 14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A14 Gene

No ASD Table

Relevant External Links for SLC2A14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC2A14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC2A14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A14 Gene

This gene is overexpressed in Testis (x26.4) and Whole Blood (x8.4).

Protein differential expression in normal tissues from HIPED for SLC2A14 Gene

This gene is overexpressed in Nasal epithelium (18.2), Monocytes (15.8), Peripheral blood mononuclear cells (14.0), Neutrophil (8.8), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC2A14 Gene

Protein tissue co-expression partners for SLC2A14 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC2A14 Gene:


SOURCE GeneReport for Unigene cluster for SLC2A14 Gene:


mRNA Expression by UniProt/SwissProt for SLC2A14 Gene:

Tissue specificity: Expressed mainly in testis.

Evidence on tissue expression from TISSUES for SLC2A14 Gene

  • Nervous system(4.5)
  • Blood(2.3)
  • Heart(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with SLC2A14: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A14 Gene

Orthologs for SLC2A14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC2A14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC2A14 34 33
  • 99.13 (n)
(Canis familiaris)
Mammalia SLC2A3 34
  • 85 (a)
(Bos Taurus)
Mammalia SLC2A3 34
  • 84 (a)
(Mus musculus)
Mammalia Slc2a3 34
  • 81 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 67 (a)
(Gallus gallus)
Aves SLC2A3 34
  • 71 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 65 (a)
(Danio rerio)
Actinopterygii LOC100330897 33
  • 60.01 (n)
slc2a3a 34
  • 57 (a)
slc2a3b 34
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Glut1 34
  • 29 (a)
(Caenorhabditis elegans)
Secernentea fgt-1 34
  • 38 (a)
R09B5.11 34
  • 35 (a)
K08F9.1 34
  • 26 (a)
C35A11.4 34
  • 26 (a)
F14E5.1 34
  • 25 (a)
F53H8.3 34
  • 24 (a)
Y37A1A.3 34
  • 22 (a)
F13B12.2 34
  • 22 (a)
ZK829.9 34
  • 22 (a)
K08H10.6 34
  • 21 (a)
F48E3.2 34
  • 20 (a)
C03B1.13 34
  • 20 (a)
Y61A9LA.1 34
  • 20 (a)
Y39E4B.5 34
  • 19 (a)
slcf-2 34
  • 17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 27 (a)
VPS73 34
  • 25 (a)
HXT13 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7972 34
  • 44 (a)
Species where no ortholog for SLC2A14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC2A14 Gene

Gene Tree for SLC2A14 (if available)
Gene Tree for SLC2A14 (if available)
Evolutionary constrained regions (ECRs) for SLC2A14: view image

Paralogs for SLC2A14 Gene

Paralogs for SLC2A14 Gene

(12) SIMAP similar genes for SLC2A14 Gene using alignment to 13 proteins:

  • B7Z844_HUMAN
  • F5H076_HUMAN
  • F5H3J0_HUMAN
  • F5H565_HUMAN
  • F5H5Q3_HUMAN
  • F5H5V7_HUMAN
  • F5H6F6_HUMAN
  • F5H7N2_HUMAN
genes like me logo Genes that share paralogs with SLC2A14: view

Variants for SLC2A14 Gene

Sequence variations from dbSNP and Humsavar for SLC2A14 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000005719 -- 7,877,929(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000058344 -- 7,877,553(-) G/ genic_upstream_transcript_variant, intron_variant
rs1000063296 -- 7,828,754(-) C/G coding_sequence_variant, missense_variant
rs1000079882 -- 7,882,736(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000086137 -- 7,826,942(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC2A14 Gene

Variant ID Type Subtype PubMed ID
dgv11e213 CNV gain 24956385
dgv1351n100 CNV gain 25217958
dgv1352n100 CNV gain 25217958
dgv1353n100 CNV gain 25217958
dgv1354n100 CNV gain 25217958
dgv1355n100 CNV gain+loss 25217958
dgv1356n100 CNV gain 25217958
dgv1357n100 CNV loss 25217958
dgv166e201 CNV deletion 23290073
dgv167e201 CNV deletion 23290073
dgv179n27 CNV gain 19166990
dgv180n27 CNV gain 19166990
dgv181n27 CNV loss 19166990
dgv182n27 CNV loss 19166990
dgv183n27 CNV loss 19166990
dgv2328n54 CNV gain 21841781
dgv2329n54 CNV gain 21841781
dgv2330n54 CNV loss 21841781
dgv2331n54 CNV gain 21841781
dgv2332n54 CNV gain+loss 21841781
dgv2333n54 CNV loss 21841781
dgv2334n54 CNV loss 21841781
dgv2335n54 CNV loss 21841781
dgv2336n54 CNV loss 21841781
dgv2337n54 CNV gain 21841781
dgv449e212 CNV gain 25503493
dgv57e55 CNV gain 17911159
dgv58e55 CNV gain 17911159
dgv59e55 CNV gain 17911159
dgv5e196 CNV duplication 17116639
dgv60e55 CNV loss 17911159
dgv61n111 CNV duplication 26073780
dgv6e196 CNV duplication 17116639
esv1281371 CNV deletion 17803354
esv2422117 CNV duplication 20811451
esv2422393 CNV duplication 17116639
esv2656717 CNV deletion 23128226
esv2658754 CNV deletion 23128226
esv2671590 CNV deletion 23128226
esv2745493 CNV deletion 23290073
esv2745494 CNV deletion 23290073
esv2751114 CNV loss 17911159
esv2751118 CNV gain 17911159
esv2751124 CNV gain 17911159
esv2759877 CNV gain+loss 17122850
esv2760250 CNV gain 21179565
esv2761054 CNV gain+loss 21179565
esv29743 CNV gain 19812545
esv34016 CNV loss 18971310
esv3548703 CNV deletion 23714750
esv3548706 CNV deletion 23714750
esv3548707 CNV deletion 23714750
esv3548708 CNV deletion 23714750
esv3548709 CNV deletion 23714750
esv3548710 CNV deletion 23714750
esv3580097 CNV loss 25503493
esv3580494 CNV gain 25503493
esv3628443 CNV gain 21293372
esv3628444 CNV loss 21293372
esv3628445 CNV gain 21293372
esv3628446 CNV loss 21293372
esv3628447 CNV gain 21293372
esv3628448 CNV loss 21293372
esv3892129 CNV gain+loss 25118596
esv3892130 CNV gain+loss 25118596
esv3892131 CNV gain 25118596
esv3892132 CNV gain 25118596
nsv1035735 CNV gain 25217958
nsv1070090 CNV deletion 25765185
nsv1146440 CNV deletion 26484159
nsv1159953 CNV duplication 26073780
nsv428270 CNV gain 18775914
nsv442253 CNV gain 18776908
nsv469100 CNV gain 19166990
nsv470264 CNV gain 18288195
nsv470265 CNV loss 18288195
nsv499606 OTHER inversion 21111241
nsv516107 CNV gain+loss 19592680
nsv557298 CNV gain 21841781
nsv596 CNV insertion 18451855
nsv7227 OTHER inversion 18451855
nsv818883 CNV gain 17921354
nsv818884 CNV gain 17921354
nsv826225 CNV gain 20364138
nsv975438 CNV duplication 23825009
nsv975644 CNV duplication 23825009
nsv983268 CNV duplication 23825009

Variation tolerance for SLC2A14 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.61; 65.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC2A14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A14 Gene

Disorders for SLC2A14 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC2A14 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC2A14

genes like me logo Genes that share disorders with SLC2A14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC2A14 Gene

Publications for SLC2A14 Gene

  1. GLUT14, a duplicon of GLUT3, is specifically expressed in testis as alternative splice forms. (PMID: 12504846) Wu X … Freeze HH (Genomics 2002) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease. (PMID: 28971850) Amir Shaghaghi M … Eck P (The American journal of clinical nutrition 2017) 3 58
  5. The SLC2A14 gene: genomic locus, tissue expression, splice variants, and subcellular localization of the protein. (PMID: 27460888) Amir Shaghaghi M … Eck P (Biochemistry and cell biology = Biochimie et biologie cellulaire 2016) 3 58

Products for SLC2A14 Gene

Sources for SLC2A14 Gene

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