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Aliases for CSF3 Gene

Aliases for CSF3 Gene

  • Colony Stimulating Factor 3 2 3 5
  • Pluripoietin 2 3 4
  • Lenograstim 2 3 4
  • Filgrastim 2 3 4
  • Colony Stimulating Factor 3 (Granulocyte) 2 3
  • C17orf33 3 4
  • GCSF 3 4
  • Granulocyte Colony Stimulating Factor 2
  • Granulocyte Colony-Stimulating Factor 3
  • Granulocyte-Colony Stimulating Factor 3
  • Chromosome 17 Open Reading Frame 33 2
  • CSF3OS 3
  • G-CSF 4

External Ids for CSF3 Gene

Previous HGNC Symbols for CSF3 Gene

  • GCSF
  • G-CSF
  • C17orf33

Previous GeneCards Identifiers for CSF3 Gene

  • GC17M037625
  • GC17P040169
  • GC17P038081
  • GC17P038546
  • GC17P035425
  • GC17P038171
  • GC17P033965

Summaries for CSF3 Gene

Entrez Gene Summary for CSF3 Gene

  • The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for CSF3 Gene

CSF3 (Colony Stimulating Factor 3) is a Protein Coding gene. Diseases associated with CSF3 include Neutropenia and Severe Congenital Neutropenia. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include enzyme binding and growth factor activity.

UniProtKB/Swiss-Prot for CSF3 Gene

  • Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

Gene Wiki entry for CSF3 Gene

Additional gene information for CSF3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSF3 Gene

Genomics for CSF3 Gene

GeneHancer (GH) Regulatory Elements for CSF3 Gene

Promoters and enhancers for CSF3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I040013 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 554.7 +3.7 3696 10.9 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A ZNF2 SLC30A9 ZNF207 ZNF143 CSF3 GC17P040017 MED24 GSDMA MSL1 ENSG00000265799 GC17P040026
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CSF3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CSF3 gene promoter:

Genomic Locations for CSF3 Gene

Genomic Locations for CSF3 Gene
2,453 bases
Plus strand

Genomic View for CSF3 Gene

Genes around CSF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSF3 Gene

Proteins for CSF3 Gene

  • Protein details for CSF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Granulocyte colony-stimulating factor
    Protein Accession:
    Secondary Accessions:
    • A8MXR7

    Protein attributes for CSF3 Gene

    207 amino acids
    Molecular mass:
    22293 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CSF3 Gene

    Alternative splice isoforms for CSF3 Gene


neXtProt entry for CSF3 Gene

Post-translational modifications for CSF3 Gene

  • O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells).
  • Glycosylation at Thr166

No data available for DME Specific Peptides for CSF3 Gene

Domains & Families for CSF3 Gene

Gene Families for CSF3 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IL-6 superfamily.
  • Belongs to the IL-6 superfamily.
genes like me logo Genes that share domains with CSF3: view

Function for CSF3 Gene

Molecular function for CSF3 Gene

GENATLAS Biochemistry:
colony-stimulating factor 3,22.3kDa,(granulocyte),playing a pivotal role in growth control of granulocytic progenitors,regulated by SPI1,MYB,others and inducing PRTN3 (see symbols),inducingJUNB and/or TOP in the proliferative response of human myeloidleukemia,putatively involved in severe congenital neutropenia
UniProtKB/Swiss-Prot Function:
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

LifeMap Function Summary for CSF3 Gene

CSF3 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for CSF3 Gene

Gene Ontology (GO) - Molecular Function for CSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity NAS 15664994
GO:0005130 granulocyte colony-stimulating factor receptor binding IBA,TAS --
GO:0008083 growth factor activity IBA --
GO:0019899 enzyme binding IPI 12393522
genes like me logo Genes that share ontologies with CSF3: view
genes like me logo Genes that share phenotypes with CSF3: view

Animal Models for CSF3 Gene

MGI Knock Outs for CSF3:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CSF3 Gene

Localization for CSF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSF3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSF3 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 3
plasma membrane 2
cytoskeleton 2
lysosome 2
mitochondrion 1
endosome 1

Gene Ontology (GO) - Cellular Components for CSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA,TAS --
genes like me logo Genes that share ontologies with CSF3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CSF3 Gene

Pathways & Interactions for CSF3 Gene

genes like me logo Genes that share pathways with CSF3: view

SIGNOR curated interactions for CSF3 Gene


Gene Ontology (GO) - Biological Process for CSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0007275 multicellular organism development TAS 2420009
GO:0008284 positive regulation of cell proliferation IBA --
GO:0010469 regulation of receptor activity IEA --
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA 23001182
genes like me logo Genes that share ontologies with CSF3: view

Drugs & Compounds for CSF3 Gene

(76) Drugs for CSF3 Gene - From: ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone (DHAP) Pharma Glucocorticoidan;ti-inflammatory 0

(49) Additional Compounds for CSF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CSF3 Gene

Compound Action Cas Number
Dexamethasone (DHAP) Glucocorticoidan;ti-inflammatory 1950-02-2
genes like me logo Genes that share compounds with CSF3: view

Drug Products

Transcripts for CSF3 Gene

Unigene Clusters for CSF3 Gene

Colony stimulating factor 3 (granulocyte):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSF3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - - -
SP9: - - -

Relevant External Links for CSF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CSF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSF3 Gene

mRNA differential expression in normal tissues according to GTEx for CSF3 Gene

This gene is overexpressed in Lung (x8.2), Heart - Atrial Appendage (x8.2), Adipose - Visceral (Omentum) (x4.3), and Muscle - Skeletal (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of CSF3 Gene:


SOURCE GeneReport for Unigene cluster for CSF3 Gene:


Evidence on tissue expression from TISSUES for CSF3 Gene

  • Blood(3.7)
  • Bone marrow(3.7)
  • Lung(2.8)
  • Pancreas(2.6)
  • Nervous system(2.6)
  • Spleen(2.5)
  • Liver(2.4)
  • Lymph node(2.3)
  • Muscle(2.3)
  • Heart(2.2)
  • Intestine(2.2)
  • Kidney(2.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with CSF3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSF3 Gene

Orthologs for CSF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CSF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CSF3 33 34
  • 97.1 (n)
(Canis familiaris)
Mammalia CSF3 33 34
  • 87.18 (n)
(Bos Taurus)
Mammalia CSF3 33 34
  • 85.98 (n)
(Rattus norvegicus)
Mammalia Csf3 33
  • 79.49 (n)
(Mus musculus)
Mammalia Csf3 33 16 34
  • 78.71 (n)
(Ornithorhynchus anatinus)
Mammalia CSF3 34
  • 59 (a)
(Monodelphis domestica)
Mammalia CSF3 34
  • 57 (a)
(Gallus gallus)
Aves CSF3 33 34
  • 56.49 (n)
(Anolis carolinensis)
Reptilia CSF3 34
  • 27 (a)
Species where no ortholog for CSF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CSF3 Gene

Gene Tree for CSF3 (if available)
Gene Tree for CSF3 (if available)

Paralogs for CSF3 Gene

No data available for Paralogs for CSF3 Gene

Variants for CSF3 Gene

Sequence variations from dbSNP and Humsavar for CSF3 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1001463387 -- 40,017,997(+) C/G downstream_transcript_variant
rs1001850784 -- 40,018,271(+) G/A downstream_transcript_variant
rs1002540759 -- 40,013,904(+) C/A upstream_transcript_variant
rs1002600196 -- 40,017,941(+) G/C downstream_transcript_variant
rs1002919825 -- 40,014,210(+) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CSF3 Gene

Variant ID Type Subtype PubMed ID
esv3573064 CNV gain 25503493
nsv1146669 OTHER inversion 26484159

Variation tolerance for CSF3 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSF3 Gene

Disorders for CSF3 Gene

MalaCards: The human disease database

(66) MalaCards diseases for CSF3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • leukopenia
severe congenital neutropenia
  • kostmann disease
felty syndrome
  • felty's syndrome
cyclic neutropenia
  • cyclic hematopoiesis
  • agranulocytosis
- elite association - COSMIC cancer census association via MalaCards
Search CSF3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CSF3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CSF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSF3 Gene

Publications for CSF3 Gene

  1. Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex. (PMID: 16492764) Tamada T … Kuroki R (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 22 58
  2. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PMID: 20485444) Wang Y … Huang W (Journal of human genetics 2010) 3 44 58
  3. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PMID: 20673868) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 44 58

Products for CSF3 Gene

Sources for CSF3 Gene

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