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Aliases for CRYGA Gene

Aliases for CRYGA Gene

  • Crystallin Gamma A 2 3 5
  • Gamma-Crystallin 5 3 4
  • CRYG1 3 4
  • Crystallin, Gamma 1 3
  • Crystallin, Gamma A 2
  • Gamma-Crystallin A 3
  • Gamma-A-Crystallin 4
  • Gamma Crystallin 5 2
  • CRY-G-A 3
  • CRYG5 3

External Ids for CRYGA Gene

Previous HGNC Symbols for CRYGA Gene

  • CRYG1

Previous GeneCards Identifiers for CRYGA Gene

  • GC02M207194
  • GC02M207750
  • GC02M208989
  • GC02M209228
  • GC02M208850
  • GC02M208733
  • GC02M209025
  • GC02M200873

Summaries for CRYGA Gene

Entrez Gene Summary for CRYGA Gene

  • Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRYGA Gene

CRYGA (Crystallin Gamma A) is a Protein Coding gene. Diseases associated with CRYGA include Cataract 8, Multiple Types and Cataract. Gene Ontology (GO) annotations related to this gene include structural constituent of eye lens. An important paralog of this gene is CRYGC.

UniProtKB/Swiss-Prot for CRYGA Gene

  • Crystallins are the dominant structural components of the vertebrate eye lens.

Gene Wiki entry for CRYGA Gene

Additional gene information for CRYGA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYGA Gene

Genomics for CRYGA Gene

GeneHancer (GH) Regulatory Elements for CRYGA Gene

Promoters and enhancers for CRYGA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J208129 Promoter/Enhancer 1.3 EPDnew ENCODE 16.7 +33.0 33031 1.1 ELF3 MLX ARID4B THRB ZNF48 ZSCAN9 RARA SLC30A9 ZNF614 RCOR1 CRYGC CRYGA IDH1-AS1 IDH1 CRYGEP LOC100533727 CRYGD LOC100507443 GC02P208116
GH02J208135 Enhancer 0.8 ENCODE 16.3 +27.5 27527 1.6 ELF3 MLX ZNF48 ZSCAN9 RARA ZNF614 CREM THAP11 MIXL1 RXRA LOC100533727 CRYGA CRYGEP IDH1-AS1 IDH1 CRYGC CRYGD GC02P208116 LOC100507443
GH02J208112 Enhancer 1 Ensembl ENCODE 10.7 +50.5 50544 1.7 MZF1 FEZF1 ZNF2 RFX5 ZNF213 ZNF366 RCOR1 OVOL3 REST ZNF843 CRYGEP CRYGB IDH1-AS1 IDH1 CRYGA FZD5 CRYGD GC02P208116
GH02J208191 Promoter 0.7 EPDnew 11.8 -26.5 -26469 0.1 MXI1 POLR2A C2orf80 CRYGA CRYGB IDH1 IDH1-AS1 GC02P208116
GH02J208187 Promoter 0.6 EPDnew 11.7 -23.5 -23500 0.1 SP1 C2orf80 CRYGA CRYGB IDH1-AS1 IDH1 GC02P208116
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRYGA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CRYGA gene promoter:
  • HTF
  • SRF (504 AA)
  • SRF
  • AREB6
  • c-Myb
  • PPAR-gamma2
  • PPAR-gamma1
  • LCR-F1
  • MIF-1
  • NCX

Genomic Locations for CRYGA Gene

Genomic Locations for CRYGA Gene
2,837 bases
Minus strand
2,837 bases
Minus strand

Genomic View for CRYGA Gene

Genes around CRYGA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRYGA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRYGA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYGA Gene

Proteins for CRYGA Gene

  • Protein details for CRYGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gamma-crystallin A
    Protein Accession:
    Secondary Accessions:
    • Q53ST5

    Protein attributes for CRYGA Gene

    174 amino acids
    Molecular mass:
    20877 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CRYGA Gene

neXtProt entry for CRYGA Gene

Post-translational modifications for CRYGA Gene

No Post-translational modifications

Other Protein References for CRYGA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CRYGA
  • Boster Bio Antibodies for CRYGA

No data available for DME Specific Peptides for CRYGA Gene

Domains & Families for CRYGA Gene

Gene Families for CRYGA Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CRYGA Gene

Suggested Antigen Peptide Sequences for CRYGA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Has a two-domain beta-structure, folded into four very similar Greek key motifs.
  • Belongs to the beta/gamma-crystallin family.
  • Has a two-domain beta-structure, folded into four very similar Greek key motifs.
  • Belongs to the beta/gamma-crystallin family.
genes like me logo Genes that share domains with CRYGA: view

Function for CRYGA Gene

Molecular function for CRYGA Gene

UniProtKB/Swiss-Prot Function:
Crystallins are the dominant structural components of the vertebrate eye lens.
GENATLAS Biochemistry:
crystallin,gamma polypeptide A

Gene Ontology (GO) - Molecular Function for CRYGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005212 structural constituent of eye lens NAS 3670288
genes like me logo Genes that share ontologies with CRYGA: view
genes like me logo Genes that share phenotypes with CRYGA: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CRYGA Gene

Localization for CRYGA Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRYGA gene
Compartment Confidence
extracellular 3
nucleus 2
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CRYGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with CRYGA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CRYGA Gene

Pathways & Interactions for CRYGA Gene

SuperPathways for CRYGA Gene

No Data Available

Interacting Proteins for CRYGA Gene

Gene Ontology (GO) - Biological Process for CRYGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002088 lens development in camera-type eye IEA --
GO:0007601 visual perception NAS 3670288
genes like me logo Genes that share ontologies with CRYGA: view

No data available for Pathways by source and SIGNOR curated interactions for CRYGA Gene

Drugs & Compounds for CRYGA Gene

No Compound Related Data Available

Transcripts for CRYGA Gene

mRNA/cDNA for CRYGA Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRYGA Gene

Crystallin, gamma A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRYGA Gene

No ASD Table

Relevant External Links for CRYGA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRYGA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRYGA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRYGA Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.4), Brain - Cortex (x7.2), Brain - Nucleus accumbens (basal ganglia) (x6.4), Brain - Hippocampus (x5.3), Brain - Amygdala (x5.2), Brain - Hypothalamus (x4.5), Brain - Anterior cingulate cortex (BA24) (x4.3), and Brain - Putamen (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for CRYGA Gene

This gene is overexpressed in Vitreous humor (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRYGA Gene

Protein tissue co-expression partners for CRYGA Gene

NURSA nuclear receptor signaling pathways regulating expression of CRYGA Gene:


SOURCE GeneReport for Unigene cluster for CRYGA Gene:


Evidence on tissue expression from TISSUES for CRYGA Gene

  • Eye(4.4)
genes like me logo Genes that share expression patterns with CRYGA: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRYGA Gene

Orthologs for CRYGA Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRYGA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRYGA 34 33
  • 99.81 (n)
(Canis familiaris)
Mammalia CRYGA 34 33
  • 83.72 (n)
(Mus musculus)
Mammalia Cryga 16 34 33
  • 83.52 (n)
(Rattus norvegicus)
Mammalia Cryga 33
  • 83.52 (n)
(Bos Taurus)
Mammalia -- 34
  • 83 (a)
  • 82.57 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 71 (a)
-- 34
  • 71 (a)
-- 34
  • 70 (a)
-- 34
  • 70 (a)
-- 34
  • 69 (a)
-- 34
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
-- 34
  • 63 (a)
(Danio rerio)
Actinopterygii crygmx 33
  • 62.02 (n)
si:dkey-57a22.14 34
  • 49 (a)
Species where no ortholog for CRYGA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRYGA Gene

Gene Tree for CRYGA (if available)
Gene Tree for CRYGA (if available)
Evolutionary constrained regions (ECRs) for CRYGA: view image

Paralogs for CRYGA Gene

(14) SIMAP similar genes for CRYGA Gene using alignment to 2 proteins:

  • Q24JT5_HUMAN
genes like me logo Genes that share paralogs with CRYGA: view

Variants for CRYGA Gene

Sequence variations from dbSNP and Humsavar for CRYGA Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs139353014 pathogenic, Congenital cataract 208,163,217(-) C/T coding_sequence_variant, missense_variant
rs1000208666 -- 208,160,726(-) C/A downstream_transcript_variant
rs1000905478 -- 208,160,448(-) C/T downstream_transcript_variant
rs1000953143 -- 208,161,736(-) G/A intron_variant
rs1001389914 -- 208,161,001(-) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CRYGA Gene

Variant ID Type Subtype PubMed ID
nsv584297 CNV gain 21841781
nsv584298 CNV loss 21841781
nsv584299 CNV loss 21841781
nsv834517 CNV loss 17160897

Variation tolerance for CRYGA Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRYGA Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRYGA Gene

Disorders for CRYGA Gene

MalaCards: The human disease database

(3) MalaCards diseases for CRYGA Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cataract 8, multiple types
  • ctrct8
  • cataracts
lens disease
  • lens diseases
- elite association - COSMIC cancer census association via MalaCards
Search CRYGA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CRYGA

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CRYGA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRYGA Gene

Publications for CRYGA Gene

  1. Analysis of single nucleotide polymorphisms of CRYGA and CRYGB genes in control population of western Indian origin. (PMID: 19384013) Kapur S … Rajkumar S (Indian journal of ophthalmology 2009) 3 44 58
  2. Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins. (PMID: 12507494) Salim A … Zaidi ZH (Biochemical and biophysical research communications 2003) 3 4 58
  3. Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts. (PMID: 12011157) Santhiya ST … Graw J (Journal of medical genetics 2002) 3 4 58
  4. Gamma-crystallins of the human eye lens: expression analysis of five members of the gene family. (PMID: 3670288) Meakin SO … Breitman ML (Molecular and cellular biology 1987) 3 4 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for CRYGA Gene

Sources for CRYGA Gene

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