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Aliases for STK35 Gene

Aliases for STK35 Gene

  • Serine/Threonine Kinase 35 2 3 5
  • Serine/Threonine-Protein Kinase 35 L1 3 4
  • CLP-36-Interacting Kinase 1 3 4
  • PDLIM1-Interacting Kinase 1 3 4
  • CLP-36 Interacting Kinase 2 3
  • STK35L1 3 4
  • CLIK-1 3 4
  • CLIK1 3 4
  • Serine Threonine Kinase 35 Long Form 3
  • Serine/Threonine-Protein Kinase 35 3
  • EC 4
  • PDIK1 4

External Ids for STK35 Gene

Previous GeneCards Identifiers for STK35 Gene

  • GC20P002070
  • GC20P002078
  • GC20P002031
  • GC20P002030

Summaries for STK35 Gene

Entrez Gene Summary for STK35 Gene

  • The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK35 Gene

STK35 (Serine/Threonine Kinase 35) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PDIK1L.

Additional gene information for STK35 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK35 Gene

Genomics for STK35 Gene

GeneHancer (GH) Regulatory Elements for STK35 Gene

Promoters and enhancers for STK35 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J002101 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 668.9 +3.3 3272 4.1 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 STK35 GC20M002101 SNRPB VPS16 ZNF343 ACTG1P3 NOP56 ENSG00000229728 PCED1A GC20M002129
GH20J002839 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.8 +741.1 741089 2.5 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF213 E2F8 ZNF207 VPS16 PCED1A CPXM1 NOP56 STK35
GH20J002206 Promoter/Enhancer 1.4 Ensembl ENCODE 9.9 +107.6 107567 1.5 HDGF ARID4B SIN3A ZNF2 ZNF48 GLIS2 ELK1 ARID2 ZNF143 ZNF548 LOC388780 ZNF343 TGM3 NOP56 VPS16 SNRPB STK35 GC20P002217
GH20J002130 Enhancer 1.1 Ensembl ENCODE dbSUPER 9.6 +33.1 33131 5.3 EBF1 CTBP1 EGR1 SCRT2 FOSL2 FOS ZNF444 SMARCA5 SCRT1 SMARCE1 STK35 GC20M002129 PIR45977 GC20P002145
GH20J002150 Enhancer 0.6 ENCODE dbSUPER 11.2 +52.0 51954 1.8 MNT PRDM10 STK35 PIR47950 GC20P002200
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STK35 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STK35 gene promoter:
  • Elk-1
  • PPAR-gamma2
  • PPAR-gamma1
  • HSF2
  • Pax-5
  • E2F
  • E2F-1
  • Spz1
  • Olf-1

Genomic Locations for STK35 Gene

Genomic Locations for STK35 Gene
77,240 bases
Plus strand
75,428 bases
Plus strand

Genomic View for STK35 Gene

Genes around STK35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK35 Gene

Proteins for STK35 Gene

  • Protein details for STK35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase 35
    Protein Accession:
    Secondary Accessions:
    • B2RBM3
    • C7ENV8
    • Q2NKW6
    • Q5T3R1
    • Q5T3R2
    • Q96AB4
    • Q9BZ06

    Protein attributes for STK35 Gene

    534 amino acids
    Molecular mass:
    58051 Da
    Quaternary structure:
    • Interacts with PDLIM1/CLP-36.
    • Association with PDLIM1 is controversial.
    • Sequence=AAI40884.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI40885.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37270.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI15590.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for STK35 Gene

Post-translational modifications for STK35 Gene

Other Protein References for STK35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STK35 Gene

Domains & Families for STK35 Gene

Gene Families for STK35 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for STK35 Gene

Suggested Antigen Peptide Sequences for STK35 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK35: view

Function for STK35 Gene

Molecular function for STK35 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for STK35 Gene

Gene Ontology (GO) - Molecular Function for STK35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with STK35: view
genes like me logo Genes that share phenotypes with STK35: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STK35

miRNA for STK35 Gene

miRTarBase miRNAs that target STK35

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK35 Gene

Localization for STK35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK35 Gene

Nucleus. Nucleus, nucleolus. Cytoplasm. Note=When associated with PDLIM1, it is mostly found in cytoplasm, localized to actin stress fibers (PubMed:11973348). However, PubMed:19756140 detected STK35 only in the nucleus, and the presence of PDLIM1 had no influence on its location. {ECO:0000269 PubMed:11973348}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK35 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STK35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with STK35: view

Pathways & Interactions for STK35 Gene

SuperPathways for STK35 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK35: view

Pathways by source for STK35 Gene

1 Qiagen pathway for STK35 Gene

Gene Ontology (GO) - Biological Process for STK35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with STK35: view

No data available for SIGNOR curated interactions for STK35 Gene

Drugs & Compounds for STK35 Gene

(2) Drugs for STK35 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for STK35 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with STK35: view

Transcripts for STK35 Gene

mRNA/cDNA for STK35 Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(57) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for STK35 Gene

Serine/threonine kinase 35:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK35 Gene

No ASD Table

Relevant External Links for STK35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STK35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STK35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STK35 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (56.0) and Stomach (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STK35 Gene

Protein tissue co-expression partners for STK35 Gene

NURSA nuclear receptor signaling pathways regulating expression of STK35 Gene:


SOURCE GeneReport for Unigene cluster for STK35 Gene:


mRNA Expression by UniProt/SwissProt for STK35 Gene:

Tissue specificity: Expressed in testis.

Evidence on tissue expression from TISSUES for STK35 Gene

  • Nervous system(4.5)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with STK35: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK35 Gene

Orthologs for STK35 Gene

This gene was present in the common ancestor of animals.

Orthologs for STK35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STK35 34 33
  • 99.63 (n)
(Monodelphis domestica)
Mammalia STK35 34
  • 98 (a)
(Bos Taurus)
Mammalia STK35 34 33
  • 96.01 (n)
(Canis familiaris)
Mammalia STK35 34 33
  • 91.37 (n)
(Rattus norvegicus)
Mammalia Stk35 33
  • 89.29 (n)
(Mus musculus)
Mammalia Stk35 16 34 33
  • 88.72 (n)
(Gallus gallus)
Aves STK35 34 33
  • 81.1 (n)
(Anolis carolinensis)
Reptilia STK35 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497495 33
  • 78.94 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4235 33
(Danio rerio)
Actinopterygii stk35 34 34
  • 72 (a)
LOC100536261 33
  • 71.24 (n)
stk35l 34
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2540 33
(Caenorhabditis elegans)
Secernentea zyg-1 34
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8364 34
  • 53 (a)
Cin.7714 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7714 33
Species where no ortholog for STK35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK35 Gene

Gene Tree for STK35 (if available)
Gene Tree for STK35 (if available)
Evolutionary constrained regions (ECRs) for STK35: view image

Paralogs for STK35 Gene

Paralogs for STK35 Gene

(4) SIMAP similar genes for STK35 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STK35: view

Variants for STK35 Gene

Sequence variations from dbSNP and Humsavar for STK35 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000064061 -- 2,136,766(+) T/C intron_variant
rs1000081791 -- 2,142,952(+) C/G intron_variant
rs1000178718 -- 2,121,175(+) A/G intron_variant
rs1000219183 -- 2,134,853(+) T/C intron_variant
rs1000285475 -- 2,129,285(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STK35 Gene

Variant ID Type Subtype PubMed ID
esv3644997 CNV loss 21293372
nsv3258 CNV insertion 18451855
nsv470535 CNV gain 18288195

Variation tolerance for STK35 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.01; 80.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STK35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK35 Gene

Disorders for STK35 Gene

Additional Disease Information for STK35

No disorders were found for STK35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK35 Gene

Publications for STK35 Gene

  1. Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates. (PMID: 19756140) Goyal P … Siess W (PloS one 2009) 3 4 22 58
  2. Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein. (PMID: 11973348) Vallenius T … Mäkelä TP (Journal of cell science 2002) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58

Products for STK35 Gene

Sources for STK35 Gene

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