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Aliases for CST11 Gene

Aliases for CST11 Gene

  • Cystatin 11 2 3 5
  • CST8L 3 4
  • Cystatin-Related Epididymal-Specific Protein 3
  • Cystatin-11 3
  • DJ322G13.6 3
  • SC13delta 3
  • CTES2 3
  • SC13 3

External Ids for CST11 Gene

Previous HGNC Symbols for CST11 Gene

  • CST8L

Previous GeneCards Identifiers for CST11 Gene

  • GC20M023419
  • GC20M023426
  • GC20M023379

Summaries for CST11 Gene

Entrez Gene Summary for CST11 Gene

  • The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein shown to have antimicrobial activity against E. coli. Alternative splicing yields two variants encoding distinct isoforms. [provided by RefSeq, Sep 2014]

GeneCards Summary for CST11 Gene

CST11 (Cystatin 11) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for CST11 Gene

  • Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization.

Gene Wiki entry for CST11 Gene

Additional gene information for CST11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CST11 Gene

Genomics for CST11 Gene

GeneHancer (GH) Regulatory Elements for CST11 Gene

Promoters and enhancers for CST11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J023658 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -207.4 -207433 3.9 HDGF FOXA2 MLX ZFP64 ARID4B YBX1 DMAP1 SLC30A9 ZNF207 PAF1 NXT1 ENSG00000230908 CST13P ENSG00000260202 CST8 CST12P CST11 POM121L3P LOC100419956 CST9
GH20J023454 Enhancer 0.7 FANTOM5 ENCODE 0.7 -3.3 -3290 2.6 ZNF316 ZMYM3 EMSY MAFK ENSG00000200208 GC20M023457 NAPB CST8 NXT1 CST11 CSTL1
GH20J023441 Enhancer 0.8 ENCODE 0.4 +10.8 10848 0.2 ELF3 PKNOX1 RB1 ZNF48 RAD21 ZNF143 THAP11 MIXL1 SMARCA5 ZNF654 NAPB CSTL1 CST11
GH20J023446 Enhancer 0.7 ENCODE 0.4 +6.1 6108 0 SOX13 CTCF USF1 FOXA2 ARID4B CEBPG ZNF644 RAD21 ZNF143 SOX5 CSTL1 CST11
GH20J023445 Enhancer 0.5 ENCODE 0.4 +7.1 7098 0.1 PKNOX1 IKZF5 CREB1 ZBTB33 FOS ZNF7 TEAD3 CST11 CSTL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CST11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CST11 gene promoter:
  • STAT3
  • AML1a
  • TBP
  • Tal-1
  • E47
  • Max1
  • c-Myc
  • MyoD
  • GATA-1
  • Arnt

Genomic Locations for CST11 Gene

Genomic Locations for CST11 Gene
2,455 bases
Minus strand
2,455 bases
Minus strand

Genomic View for CST11 Gene

Genes around CST11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CST11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CST11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CST11 Gene

Proteins for CST11 Gene

  • Protein details for CST11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q0VAF2
    • Q0VAF3
    • Q8WXU5
    • Q8WXU6
    • Q9H113

    Protein attributes for CST11 Gene

    138 amino acids
    Molecular mass:
    16506 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CST11 Gene


neXtProt entry for CST11 Gene

Post-translational modifications for CST11 Gene

  • Glycosylation at posLast=132132
  • Modification sites at PhosphoSitePlus

Other Protein References for CST11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CST11 Gene

Domains & Families for CST11 Gene

Gene Families for CST11 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CST11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cystatin family.
  • Belongs to the cystatin family.
genes like me logo Genes that share domains with CST11: view

Function for CST11 Gene

Molecular function for CST11 Gene

UniProtKB/Swiss-Prot Function:
Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization.

Phenotypes From GWAS Catalog for CST11 Gene

Gene Ontology (GO) - Molecular Function for CST11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IBA --
GO:0004869 cysteine-type endopeptidase inhibitor activity IBA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with CST11: view
genes like me logo Genes that share phenotypes with CST11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CST11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CST11 Gene

Localization for CST11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CST11 Gene

Secreted. Note=Probably secreted into the epididymis lumen, where it localizes to the outer surface of sperm. Specifically localizes to the postacrosomal and tail regions of sperm. {ECO:0000269 PubMed:12072414}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CST11 gene
Compartment Confidence
extracellular 5
nucleus 4

Gene Ontology (GO) - Cellular Components for CST11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0005634 nucleus IMP 12072414
GO:0005737 cytoplasm IMP 12072414
GO:0036126 sperm flagellum IDA 12072414
genes like me logo Genes that share ontologies with CST11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CST11 Gene

Pathways & Interactions for CST11 Gene

SuperPathways for CST11 Gene

No Data Available

Interacting Proteins for CST11 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9H112-CST11_HUMAN ENSP00000366208 for CST11 Gene via IID STRING

Gene Ontology (GO) - Biological Process for CST11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0030521 androgen receptor signaling pathway ISS 12072414
GO:0031640 killing of cells of other organism IDA 12072414
GO:0042742 defense response to bacterium IEA --
GO:0050829 defense response to Gram-negative bacterium IDA 12072414
genes like me logo Genes that share ontologies with CST11: view

No data available for Pathways by source and SIGNOR curated interactions for CST11 Gene

Drugs & Compounds for CST11 Gene

No Compound Related Data Available

Transcripts for CST11 Gene

mRNA/cDNA for CST11 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CST11 Gene

Cystatin 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CST11 Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP2: -

Relevant External Links for CST11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CST11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CST11 Gene

mRNA differential expression in normal tissues according to GTEx for CST11 Gene

This gene is overexpressed in Stomach (x13.0), Testis (x9.4), Colon - Sigmoid (x5.5), and Bladder (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of CST11 Gene:


SOURCE GeneReport for Unigene cluster for CST11 Gene:


mRNA Expression by UniProt/SwissProt for CST11 Gene:

Tissue specificity: Detected in the epithelium and lumen of the epididymis, and in sperm (at protein level).
genes like me logo Genes that share expression patterns with CST11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CST11 Gene

Orthologs for CST11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CST11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CST11 34 33
  • 98.07 (n)
(Canis familiaris)
Mammalia CST11 34 33
  • 74.45 (n)
(Mus musculus)
Mammalia Cst11 16 34 33
  • 71.57 (n)
(Rattus norvegicus)
Mammalia Cst11 33
  • 69.32 (n)
(Bos Taurus)
Mammalia CST11 34 33
  • 66.42 (n)
(Gallus gallus)
Aves gga-mir-3526 34
  • 25 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 24 (a)
(Danio rerio)
Actinopterygii zgc:163030 34
  • 23 (a)
Species where no ortholog for CST11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CST11 Gene

Gene Tree for CST11 (if available)
Gene Tree for CST11 (if available)
Evolutionary constrained regions (ECRs) for CST11: view image

Paralogs for CST11 Gene

(8) SIMAP similar genes for CST11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CST11: view

No data available for Paralogs for CST11 Gene

Variants for CST11 Gene

Sequence variations from dbSNP and Humsavar for CST11 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000512010 -- 23,450,768(-) G/A intron_variant
rs1001286524 -- 23,454,639(-) G/A upstream_transcript_variant
rs1001410668 -- 23,454,051(-) ACACACACACA/ACACACACA upstream_transcript_variant
rs1002986022 -- 23,451,390(-) C/T intron_variant
rs1003429150 -- 23,451,650(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CST11 Gene

Variant ID Type Subtype PubMed ID
esv3645524 CNV gain 21293372
esv3645525 CNV gain 21293372
nsv1063655 CNV gain 25217958
nsv1065390 CNV loss 25217958
nsv458949 CNV gain 19166990
nsv470544 CNV gain 18288195
nsv585722 CNV loss 21841781
nsv585723 CNV gain 21841781

Variation tolerance for CST11 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CST11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CST11 Gene

Disorders for CST11 Gene

Additional Disease Information for CST11

No disorders were found for CST11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CST11 Gene

Publications for CST11 Gene

  1. Evolution and human tissue expression of the Cres/Testatin subgroup genes, a reproductive tissue specific subgroup of the type 2 cystatins. (PMID: 20565543) Frygelius J … Töhönen V (Evolution & development 2010) 2 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Cystatin 11: a new member of the cystatin type 2 family. (PMID: 12072414) Hamil KG … Hall SH (Endocrinology 2002) 3 4 58
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  5. Reactivation of p53 function in synovial sarcoma cells by inhibition of p53-HDM2 interaction. (PMID: 19081178) D'Arcy P … Brodin B (Cancer letters 2009) 3 58

Products for CST11 Gene

Sources for CST11 Gene

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