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Aliases for RNF32 Gene

Aliases for RNF32 Gene

  • Ring Finger Protein 32 2 3 5
  • RING Finger Protein 32 3
  • FKSG33 3
  • HSD15 3
  • LMBR2 3

External Ids for RNF32 Gene

Previous GeneCards Identifiers for RNF32 Gene

  • GC07P154663
  • GC07P155735
  • GC07P155850
  • GC07P155932
  • GC07P156126
  • GC07P156117
  • GC07P156433
  • GC07P150166

Summaries for RNF32 Gene

Entrez Gene Summary for RNF32 Gene

  • The protein encoded by this gene contains two RING ring finger motifs. RING finger motifs are present in a variety of functionally distinct proteins and are known to be involved in protein-DNA or protein-protein interactions. This gene was found to be expressed during spermatogenesis, most likely in spermatocytes and/or in spermatids. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for RNF32 Gene

RNF32 (Ring Finger Protein 32) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RNF32 Gene

  • May play a role in sperm formation.

Gene Wiki entry for RNF32 Gene

Additional gene information for RNF32 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF32 Gene

Genomics for RNF32 Gene

GeneHancer (GH) Regulatory Elements for RNF32 Gene

Promoters and enhancers for RNF32 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J156638 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.2 168 3.4 SMAD1 ARNT SIN3A YY1 POLR2B ZNF766 E2F8 ZNF143 SP3 REST LINC01006 RNF32 PIR39241 GC07M156641 RBM33 NOM1
GH07J156614 Enhancer 1.4 FANTOM5 Ensembl ENCODE 13.8 -24.3 -24296 4 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 ATF7 NFKBIZ LINC01006 RNF32 NOM1 MNX1 GC07P156625 GC07M156563
GH07J156607 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.3 -30.2 -30222 5.4 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 TCF12 GATA2 NFKBIZ RXRA LINC01006 RNF32 GC07P156625 GC07M156563
GH07J156523 Enhancer 0.6 FANTOM5 23.7 -116.7 -116660 0.1 CBX1 L3MBTL2 GABPB1 ZBTB11 EHMT2 ELF1 ZBTB40 GABPA RNF32 LINC00244 PIR53126 LINC01006
GH07J155917 Enhancer 1.2 Ensembl ENCODE 9.8 -721.6 -721571 3.3 PKNOX1 CLOCK FOXA2 MLX YBX1 DMAP1 ZNF2 YY1 ZNF207 ZNF548 PAXIP1-AS2 RBM33 PAXIP1 ENSG00000273183 PAXIP1-AS1 RNF32 LOC389602 GC07M155822
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF32 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF32 gene promoter:
  • Sox5
  • Sox9
  • POU6F1 (c2)
  • LHX3b
  • Lhx3a
  • Nkx2-5
  • HTF
  • CHOP-10
  • C/EBPalpha
  • GATA-1

Genomic Locations for RNF32 Gene

Genomic Locations for RNF32 Gene
37,613 bases
Plus strand
36,850 bases
Plus strand

Genomic View for RNF32 Gene

Genes around RNF32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF32 Gene

Proteins for RNF32 Gene

  • Protein details for RNF32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 32
    Protein Accession:
    Secondary Accessions:
    • Q6FIB3
    • Q6X7T4
    • Q8N6V8
    • Q8TDG0
    • Q96BM5
    • Q9Y6U1

    Protein attributes for RNF32 Gene

    362 amino acids
    Molecular mass:
    41516 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNF32 Gene


neXtProt entry for RNF32 Gene

Post-translational modifications for RNF32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RNF32 Gene

Domains & Families for RNF32 Gene

Gene Families for RNF32 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RNF32 Gene

Suggested Antigen Peptide Sequences for RNF32 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF32: view

No data available for UniProtKB/Swiss-Prot for RNF32 Gene

Function for RNF32 Gene

Molecular function for RNF32 Gene

UniProtKB/Swiss-Prot Function:
May play a role in sperm formation.

Phenotypes From GWAS Catalog for RNF32 Gene

Gene Ontology (GO) - Molecular Function for RNF32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21163940
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF32: view
genes like me logo Genes that share phenotypes with RNF32: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RNF32

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF32

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF32 Gene

Localization for RNF32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF32 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF32 gene
Compartment Confidence
endosome 4
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RNF32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IDA --
GO:0016235 aggresome IDA 11890671
genes like me logo Genes that share ontologies with RNF32: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNF32 Gene

Pathways & Interactions for RNF32 Gene

SuperPathways for RNF32 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF32 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF32 Gene

Drugs & Compounds for RNF32 Gene

No Compound Related Data Available

Transcripts for RNF32 Gene

Unigene Clusters for RNF32 Gene

Ring finger protein 32:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF32

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF32 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -

Relevant External Links for RNF32 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF32 Gene

mRNA differential expression in normal tissues according to GTEx for RNF32 Gene

This gene is overexpressed in Testis (x14.1).

Protein differential expression in normal tissues from HIPED for RNF32 Gene

This gene is overexpressed in Stomach (39.9) and Fetal testis (29.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF32 Gene

Protein tissue co-expression partners for RNF32 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF32 Gene:


SOURCE GeneReport for Unigene cluster for RNF32 Gene:


mRNA Expression by UniProt/SwissProt for RNF32 Gene:

Tissue specificity: Highly expressed in testis, less abundant in ovary.

Evidence on tissue expression from TISSUES for RNF32 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with RNF32: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF32 Gene

Orthologs for RNF32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF32 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF32 34 33
  • 99.17 (n)
(Canis familiaris)
Mammalia RNF32 34 33
  • 83.33 (n)
(Mus musculus)
Mammalia Rnf32 16 34 33
  • 79.83 (n)
(Bos Taurus)
Mammalia RNF32 34 33
  • 78.86 (n)
(Monodelphis domestica)
Mammalia RNF32 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia RNF32 34
  • 66 (a)
(Gallus gallus)
Aves RNF32 34 33
  • 65.33 (n)
(Anolis carolinensis)
Reptilia RNF32 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf32 33
  • 64.66 (n)
Str.13169 33
(Danio rerio)
Actinopterygii rnf32 34 33
  • 56.93 (n)
Dr.18813 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7850 33
Species where no ortholog for RNF32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF32 Gene

Gene Tree for RNF32 (if available)
Gene Tree for RNF32 (if available)
Evolutionary constrained regions (ECRs) for RNF32: view image

Paralogs for RNF32 Gene

No data available for Paralogs for RNF32 Gene

Variants for RNF32 Gene

Sequence variations from dbSNP and Humsavar for RNF32 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000084089 -- 156,655,188(+) T/C intron_variant
rs1000198825 -- 156,667,919(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000282111 -- 156,667,347(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000291425 -- 156,667,613(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000311672 -- 156,639,803(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF32 Gene

Variant ID Type Subtype PubMed ID
esv3615671 CNV loss 21293372
nsv1023469 CNV gain 25217958
nsv525099 CNV gain 19592680
nsv6020 CNV insertion 18451855
nsv609209 CNV gain 21841781
nsv831198 CNV loss 17160897

Variation tolerance for RNF32 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.11; 87.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF32 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF32 Gene

Disorders for RNF32 Gene

Additional Disease Information for RNF32

No disorders were found for RNF32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF32 Gene

Publications for RNF32 Gene

  1. A double RING-H2 domain in RNF32, a gene expressed during sperm formation. (PMID: 11890671) van Baren MJ … Heutink P (Biochemical and biophysical research communications 2002) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  5. RING finger proteins are involved in the progression of barrett esophagus to esophageal adenocarcinoma: a preliminary study. (PMID: 25228972) Wang XW … Fang DC (Gut and liver 2014) 3 58

Products for RNF32 Gene

Sources for RNF32 Gene

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