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Aliases for CPNE4 Gene

Aliases for CPNE4 Gene

  • Copine 4 2 3 5
  • Copine IV 2 3 4
  • Copine 8 2 3
  • Copine-4 3
  • Copine-8 4
  • COPN4 3
  • CPN4 3

External Ids for CPNE4 Gene

Previous GeneCards Identifiers for CPNE4 Gene

  • GC03M128164
  • GC03M131993
  • GC03M132534
  • GC03M132574
  • GC03M132573
  • GC03M132736
  • GC03M131253
  • GC03M128638

Summaries for CPNE4 Gene

Entrez Gene Summary for CPNE4 Gene

  • This gene belongs to the highly conserved copine family. It encodes a calcium-dependent, phospholipid-binding protein, which may be involved in membrane trafficking, mitogenesis and development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for CPNE4 Gene

CPNE4 (Copine 4) is a Protein Coding gene. An important paralog of this gene is CPNE7.

UniProtKB/Swiss-Prot for CPNE4 Gene

  • Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.

Gene Wiki entry for CPNE4 Gene

Additional gene information for CPNE4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE4 Gene

Genomics for CPNE4 Gene

GeneHancer (GH) Regulatory Elements for CPNE4 Gene

Promoters and enhancers for CPNE4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J132034 Promoter/Enhancer 1.4 EPDnew ENCODE 650.1 +250.5 250465 0.2 ARID4B SIN3A DMAP1 ZNF2 IRF4 ZNF48 ZNF766 ZNF143 SP3 SP5 CPNE4 GC03P132040 GC03M131998 MIR5704
GH03J132282 Enhancer 0.9 Ensembl ENCODE 659.4 +0.8 814 3.5 CTCF USF1 MAX POLR2A HNF4G STAT1 RXRA ZNF740 CEBPB USF2 CPNE4 ACPP RPL7P16
GH03J132316 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 5.5 -32.2 -32174 2.7 PKNOX1 NFIB NEUROD1 MZF1 SIN3A FEZF1 ZNF2 ZNF335 FOS REST ACPP ENSG00000261167 CPNE4 GC03P132328
GH03J131902 Enhancer 0.6 ENCODE 14.5 +381.5 381537 2.2 FOXA2 TEAD1 TEAD3 SP1 JUND CEBPA TCF7 FOS FOSL2 CPNE4 ENSG00000248468 MIR5704 LOC105374113
GH03J131797 Enhancer 0.8 FANTOM5 ENCODE 7.7 +488.8 488823 0.2 NANOG EBF1 MEF2B BCL11A POLR2A IKZF1 NBN RUNX3 IKZF2 CPNE4 LOC105374113 ENSG00000251447
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CPNE4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPNE4 gene promoter:
  • AP-2alpha
  • Nkx2-5
  • CREB
  • deltaCREB
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • GR
  • GR-alpha
  • GR-beta

Genomic Locations for CPNE4 Gene

Genomic Locations for CPNE4 Gene
751,993 bases
Minus strand
751,856 bases
Minus strand

Genomic View for CPNE4 Gene

Genes around CPNE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPNE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPNE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE4 Gene

Proteins for CPNE4 Gene

  • Protein details for CPNE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DNC5
    • Q8TEX1

    Protein attributes for CPNE4 Gene

    557 amino acids
    Molecular mass:
    62395 Da
    Quaternary structure:
    • Interacts (via VWFA domain) with ACTB, BCOR, BICD2, CCDC22, CDC42BPB, CEP162, MYCBP2, NONO, PDCD6, PITPNM2, RDX, SKIL, SKT, SPTBN1, UBE2O and WTAP (PubMed:12522145).

    Alternative splice isoforms for CPNE4 Gene


neXtProt entry for CPNE4 Gene

Post-translational modifications for CPNE4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CPNE4 Gene

Domains & Families for CPNE4 Gene

Gene Families for CPNE4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CPNE4 Gene

Suggested Antigen Peptide Sequences for CPNE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the copine family.
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE4: view

Function for CPNE4 Gene

Molecular function for CPNE4 Gene

UniProtKB/Swiss-Prot Function:
Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.

Phenotypes From GWAS Catalog for CPNE4 Gene

Gene Ontology (GO) - Molecular Function for CPNE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12522145
genes like me logo Genes that share ontologies with CPNE4: view
genes like me logo Genes that share phenotypes with CPNE4: view

Animal Model Products

miRNA for CPNE4 Gene

miRTarBase miRNAs that target CPNE4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPNE4 Gene

Localization for CPNE4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPNE4 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CPNE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with CPNE4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CPNE4 Gene

Pathways & Interactions for CPNE4 Gene

SuperPathways for CPNE4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPNE4 Gene


No data available for Pathways by source and SIGNOR curated interactions for CPNE4 Gene

Drugs & Compounds for CPNE4 Gene

(1) Drugs for CPNE4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with CPNE4: view

Transcripts for CPNE4 Gene

mRNA/cDNA for CPNE4 Gene

Unigene Clusters for CPNE4 Gene

Copine IV:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1: -
SP3: -

Relevant External Links for CPNE4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPNE4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPNE4 Gene

mRNA differential expression in normal tissues according to GTEx for CPNE4 Gene

This gene is overexpressed in Prostate (x7.6), Brain - Frontal Cortex (BA9) (x6.1), Brain - Hippocampus (x6.0), Brain - Anterior cingulate cortex (BA24) (x5.9), Brain - Cortex (x5.1), and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for CPNE4 Gene

This gene is overexpressed in Fetal Brain (20.6), Brain (20.5), Frontal cortex (11.5), and Heart (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPNE4 Gene

Protein tissue co-expression partners for CPNE4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CPNE4 Gene:


SOURCE GeneReport for Unigene cluster for CPNE4 Gene:


mRNA Expression by UniProt/SwissProt for CPNE4 Gene:

Tissue specificity: Widely expressed (PubMed:12670487, PubMed:12949241). Expressed strongly in the brain, heart and prostate (PubMed:12670487, PubMed:12949241). Expressed strongly in peripheral blood leukocytes (PubMed:12949241).

Evidence on tissue expression from TISSUES for CPNE4 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with CPNE4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CPNE4 Gene

Orthologs for CPNE4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPNE4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPNE4 34
  • 100 (a)
(Pan troglodytes)
Mammalia CPNE4 34 33
  • 99.88 (n)
(Monodelphis domestica)
Mammalia CPNE4 34
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia CPNE4 34
  • 97 (a)
(Canis familiaris)
Mammalia CPNE4 34 33
  • 94.09 (n)
(Mus musculus)
Mammalia Cpne4 16 34 33
  • 91.26 (n)
(Rattus norvegicus)
Mammalia Cpne4 33
  • 90.37 (n)
(Gallus gallus)
Aves CPNE4 34 33
  • 86.37 (n)
(Anolis carolinensis)
Reptilia CPNE4 34
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne4 33
  • 81.01 (n)
(Danio rerio)
Actinopterygii CPNE4 (1 of 2) 34
  • 87 (a)
cpne4 34 33
  • 78.54 (n)
(Caenorhabditis elegans)
Secernentea gem-4 34
  • 35 (a)
nra-1 34
  • 34 (a)
cpna-5 34
  • 21 (a)
cpna-4 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 57 (a)
Species where no ortholog for CPNE4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPNE4 Gene

Gene Tree for CPNE4 (if available)
Gene Tree for CPNE4 (if available)
Evolutionary constrained regions (ECRs) for CPNE4: view image

Paralogs for CPNE4 Gene

Paralogs for CPNE4 Gene

(9) SIMAP similar genes for CPNE4 Gene using alignment to 5 proteins:

  • D6RI99_HUMAN
  • Q4G168_HUMAN Pseudogenes for CPNE4 Gene

genes like me logo Genes that share paralogs with CPNE4: view

Variants for CPNE4 Gene

Sequence variations from dbSNP and Humsavar for CPNE4 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000008961 -- 131,975,275(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000010645 -- 131,698,864(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000015986 -- 131,816,784(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000032413 -- 132,093,466(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000035412 -- 131,975,434(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CPNE4 Gene

Variant ID Type Subtype PubMed ID
dgv2599n106 CNV deletion 24896259
dgv2600n106 CNV deletion 24896259
dgv2601n106 CNV deletion 24896259
dgv2602n106 CNV deletion 24896259
dgv302e215 CNV deletion 23714750
dgv825n67 CNV loss 20364138
dgv8591n54 CNV loss 21841781
dgv8592n54 CNV gain 21841781
dgv8593n54 CNV gain 21841781
dgv8594n54 CNV gain+loss 21841781
dgv8595n54 CNV gain 21841781
dgv8596n54 CNV gain 21841781
dgv8597n54 CNV gain+loss 21841781
dgv8598n54 CNV loss 21841781
dgv8599n54 CNV loss 21841781
dgv8600n54 CNV loss 21841781
dgv886e199 CNV deletion 23128226
dgv935e214 CNV gain 21293372
dgv936e214 CNV loss 21293372
dgv937e214 CNV loss 21293372
esv1088025 CNV insertion 17803354
esv1724962 CNV insertion 17803354
esv1987535 CNV deletion 18987734
esv2039184 CNV deletion 18987734
esv2040947 CNV deletion 18987734
esv22316 CNV gain 19812545
esv22482 CNV gain 19812545
esv22865 CNV loss 19812545
esv2322581 CNV deletion 18987734
esv2421563 CNV deletion 20811451
esv2514810 CNV deletion 19546169
esv2557143 CNV deletion 19546169
esv2574380 CNV deletion 19546169
esv2637398 CNV deletion 19546169
esv2658353 CNV deletion 23128226
esv2661746 CNV deletion 23128226
esv2672134 CNV deletion 23128226
esv2677391 CNV deletion 23128226
esv2725922 CNV deletion 23290073
esv2725923 CNV deletion 23290073
esv2725924 CNV deletion 23290073
esv2725925 CNV deletion 23290073
esv2725926 CNV deletion 23290073
esv2725927 CNV deletion 23290073
esv2725928 CNV deletion 23290073
esv2725930 CNV deletion 23290073
esv2725931 CNV deletion 23290073
esv275136 CNV loss 21479260
esv2759178 CNV gain 17122850
esv3426719 CNV insertion 20981092
esv3562545 CNV deletion 23714750
esv3562548 CNV deletion 23714750
esv3562551 CNV deletion 23714750
esv3569004 CNV loss 25503493
esv3569005 CNV loss 25503493
esv3597793 CNV loss 21293372
esv3597796 CNV loss 21293372
esv3597797 CNV loss 21293372
esv3597799 CNV gain 21293372
esv3597801 CNV loss 21293372
esv3597802 CNV loss 21293372
esv3597805 CNV loss 21293372
esv3597807 CNV loss 21293372
esv3597808 CNV loss 21293372
esv3597809 CNV loss 21293372
esv3597813 CNV loss 21293372
esv5730 CNV loss 19470904
esv7928 CNV loss 19470904
esv8024 CNV loss 19470904
nsv1000282 CNV loss 25217958
nsv1002408 CNV loss 25217958
nsv1006656 CNV gain 25217958
nsv10325 CNV loss 18304495
nsv1074624 CNV deletion 25765185
nsv1127994 CNV deletion 24896259
nsv1139155 CNV deletion 24896259
nsv1139156 CNV deletion 24896259
nsv1139159 CNV deletion 24896259
nsv1143063 CNV tandem duplication 24896259
nsv1149526 CNV deletion 26484159
nsv1152356 CNV deletion 26484159
nsv1160984 CNV duplication 26073780
nsv4007 CNV deletion 18451855
nsv4008 CNV insertion 18451855
nsv4009 CNV deletion 18451855
nsv433376 CNV loss 18776910
nsv437883 CNV loss 16468122
nsv499013 CNV loss 21111241
nsv508244 CNV deletion 20534489
nsv508955 CNV insertion 20534489
nsv511224 CNV loss 21212237
nsv512813 CNV insertion 21212237
nsv513073 CNV loss 21212237
nsv514166 CNV loss 21397061
nsv516494 CNV loss 19592680
nsv517016 CNV loss 19592680
nsv527967 CNV loss 19592680
nsv591724 CNV loss 21841781
nsv591725 CNV loss 21841781
nsv591727 CNV gain 21841781
nsv591730 CNV gain+loss 21841781
nsv591742 CNV loss 21841781
nsv591752 CNV loss 21841781
nsv591756 CNV gain 21841781
nsv591769 CNV gain 21841781
nsv591770 CNV loss 21841781
nsv591771 CNV loss 21841781
nsv819184 CNV loss 19587683
nsv822255 CNV loss 20364138
nsv829724 CNV gain 17160897
nsv829725 CNV gain 17160897
nsv829727 CNV gain+loss 17160897
nsv956831 CNV deletion 24416366

Variation tolerance for CPNE4 Gene

Residual Variation Intolerance Score: 6.77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPNE4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPNE4 Gene

Disorders for CPNE4 Gene

Additional Disease Information for CPNE4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CPNE4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPNE4 Gene

Publications for CPNE4 Gene

  1. Cloning, molecular characterization, and expression analysis of Copine 8. (PMID: 12670487) Maitra R … Lee B (Biochemical and biophysical research communications 2003) 2 3 4 58
  2. Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PMID: 21507922) Ramsuran V … Ndung'u T (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2011) 3 44 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CPNE4 Gene

Sources for CPNE4 Gene

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