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Aliases for TMEM150A Gene

Aliases for TMEM150A Gene

  • Transmembrane Protein 150A 2 3 3 5
  • Transmembrane Protein 150 2 3 4
  • Tentonin 1 2 3
  • TMEM150 3 4
  • Fasting-Inducible Integral Membrane Protein TM6P1 3
  • TM6P1 3
  • TTN1 3

External Ids for TMEM150A Gene

Previous HGNC Symbols for TMEM150A Gene

  • TMEM150

Previous GeneCards Identifiers for TMEM150A Gene

  • GC02M085680
  • GC02M085825
  • GC02M085723

Summaries for TMEM150A Gene

GeneCards Summary for TMEM150A Gene

TMEM150A (Transmembrane Protein 150A) is a Protein Coding gene. An important paralog of this gene is TMEM150B.

UniProtKB/Swiss-Prot for TMEM150A Gene

  • Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex (PubMed:25608530). Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:25608530). May also play a role in fasting-induced catabolism (By similarity).

Gene Wiki entry for TMEM150A Gene

Additional gene information for TMEM150A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM150A Gene

Genomics for TMEM150A Gene

GeneHancer (GH) Regulatory Elements for TMEM150A Gene

Promoters and enhancers for TMEM150A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J085600 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 -2.1 -2091 8.7 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 ZNF143 KLF13 USP39 TMEM150A VAMP8 RETSAT C2orf68 LOC105374845 SNORD94 GGCX SH2D6 CAPG
GH02J085575 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 12.4 +24.9 24852 4.7 HDGF ARID4B SIN3A DMAP1 ZNF48 YY1 POLR2B ZNF766 GLIS2 NFKBIZ VAMP8 VAMP5 USP39 TMEM150A GGCX MAT2A SH2D6 CAPG RETSAT ELMOD3
GH02J085560 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.6 +41.9 41943 2.3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B VAMP8 GGCX USP39 CAPG SH2D6 TMEM150A ELMOD3 RETSAT SNORD94 GC02P085546
GH02J085497 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +103.3 103313 4.7 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 POLR2B ZNF766 CBX5 USP39 SNORD94 MAT2A ELMOD3 LOC100996506 RN7SL251P RNU7-64P CAPG KDM3A C2orf68
GH02J085548 Enhancer 1.3 Ensembl ENCODE dbSUPER 11 +52.7 52705 4 HDGF FOXA2 ARID4B SIN3A IRF4 ZNF48 ARID2 ZNF143 ATF7 FOS USP39 GGCX VAMP8 SH2D6 CAPG TGOLN2 TMEM150A RN7SL251P RNU7-64P ELMOD3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM150A on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM150A Gene

Genomic Locations for TMEM150A Gene
chr2:85,598,547-85,603,196
(GRCh38/hg38)
Size:
4,650 bases
Orientation:
Minus strand
chr2:85,825,670-85,830,319
(GRCh37/hg19)
Size:
4,650 bases
Orientation:
Minus strand

Genomic View for TMEM150A Gene

Genes around TMEM150A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM150A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM150A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM150A Gene

Proteins for TMEM150A Gene

  • Protein details for TMEM150A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TG1-T150A_HUMAN
    Recommended name:
    Transmembrane protein 150A
    Protein Accession:
    Q86TG1
    Secondary Accessions:
    • A8K764
    • B7WPQ9
    • D6W5L2
    • Q8N2R6

    Protein attributes for TMEM150A Gene

    Size:
    271 amino acids
    Molecular mass:
    28835 Da
    Quaternary structure:
    • Interacts (via C-terminal cytoplasmic tail) with PI4KA.

    Alternative splice isoforms for TMEM150A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM150A Gene

Post-translational modifications for TMEM150A Gene

  • Glycosylation at posLast=4141 and isoforms=37
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM150A Gene

Domains & Families for TMEM150A Gene

Gene Families for TMEM150A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM150A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM150A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86TG1

UniProtKB/Swiss-Prot:

T150A_HUMAN :
  • Belongs to the DRAM/TMEM150 family.
Family:
  • Belongs to the DRAM/TMEM150 family.
genes like me logo Genes that share domains with TMEM150A: view

Function for TMEM150A Gene

Molecular function for TMEM150A Gene

UniProtKB/Swiss-Prot Function:
Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex (PubMed:25608530). Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:25608530). May also play a role in fasting-induced catabolism (By similarity).

Phenotypes From GWAS Catalog for TMEM150A Gene

Gene Ontology (GO) - Molecular Function for TMEM150A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM150A: view
genes like me logo Genes that share phenotypes with TMEM150A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM150A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM150A Gene

Localization for TMEM150A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM150A Gene

Cell membrane; Multi-pass membrane protein. Note=Localizes mainly at the plasma membrane; only a minor fraction localizes on intracellular structures (PubMed:25608530). {ECO:0000269 PubMed:25608530}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM150A gene
Compartment Confidence
plasma membrane 5
lysosome 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM150A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IBA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IDA 25608530
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM150A: view

Pathways & Interactions for TMEM150A Gene

SuperPathways for TMEM150A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM150A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009056 catabolic process IEA --
GO:0010506 regulation of autophagy IBA --
GO:0046854 phosphatidylinositol phosphorylation IMP 25608530
GO:0072659 protein localization to plasma membrane IDA 25608530
genes like me logo Genes that share ontologies with TMEM150A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM150A Gene

Drugs & Compounds for TMEM150A Gene

No Compound Related Data Available

Transcripts for TMEM150A Gene

Unigene Clusters for TMEM150A Gene

Transmembrane protein 150A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM150A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - - - -
SP11: - - - - - - -
SP12: - - - -
SP13: - - - - -
SP14: - -

Relevant External Links for TMEM150A Gene

GeneLoc Exon Structure for
TMEM150A
ECgene alternative splicing isoforms for
TMEM150A

Expression for TMEM150A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM150A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM150A Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM150A Gene



Protein tissue co-expression partners for TMEM150A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM150A Gene:

TMEM150A

SOURCE GeneReport for Unigene cluster for TMEM150A Gene:

Hs.591559

Evidence on tissue expression from TISSUES for TMEM150A Gene

  • Nervous system(4.8)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with TMEM150A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM150A Gene

Orthologs for TMEM150A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM150A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM150A 34 33
  • 99.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM150A 34 33
  • 89.91 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem150a 33
  • 89.54 (n)
mouse
(Mus musculus)
Mammalia Tmem150a 16 34 33
  • 89.05 (n)
cow
(Bos Taurus)
Mammalia TMEM150A 34 33
  • 88.31 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM150A 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM150A 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM150A 34
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM150A 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem150a 33
  • 70.23 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15465 33
zebrafish
(Danio rerio)
Actinopterygii zgc:66242 33
  • 68.27 (n)
tmem150a 34
  • 64 (a)
OneToMany
TMEM150A (1 of 4) 34
  • 64 (a)
OneToMany
TMEM150A (4 of 4) 34
  • 53 (a)
OneToMany
TMEM150A (2 of 4) 34
  • 30 (a)
OneToMany
zgc66242 33
Species where no ortholog for TMEM150A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM150A Gene

ENSEMBL:
Gene Tree for TMEM150A (if available)
TreeFam:
Gene Tree for TMEM150A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM150A: view image

Paralogs for TMEM150A Gene

Paralogs for TMEM150A Gene

genes like me logo Genes that share paralogs with TMEM150A: view

Variants for TMEM150A Gene

Sequence variations from dbSNP and Humsavar for TMEM150A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000143101 -- 85,598,708(-) C/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000730365 -- 85,599,764(-) C/T intron_variant
rs1001842985 -- 85,598,594(-) C/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1002387368 -- 85,598,988(-) T/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1003606506 -- 85,598,242(-) T/C downstream_transcript_variant

Variation tolerance for TMEM150A Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM150A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM150A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM150A Gene

Disorders for TMEM150A Gene

Additional Disease Information for TMEM150A

No disorders were found for TMEM150A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM150A Gene

Publications for TMEM150A Gene

  1. Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function. (PMID: 27321926) Hong GS … Oh U (Neuron 2016) 2 3 58
  2. Plasticity of PI4KIIIα interactions at the plasma membrane. (PMID: 25608530) Chung J … De Camilli P (EMBO reports 2015) 3 4 58
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TMEM150A Gene

Sources for TMEM150A Gene

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