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Aliases for KLF17 Gene

Aliases for KLF17 Gene

  • Kruppel Like Factor 17 2 3 5
  • Zinc Finger Protein 393 2 3 4
  • ZNF393 3 4
  • Novel Zinc-Finger Protein 3
  • Krueppel-Like Factor 17 3
  • Zfp393 3

External Ids for KLF17 Gene

Previous HGNC Symbols for KLF17 Gene

  • ZNF393

Previous GeneCards Identifiers for KLF17 Gene

  • GC01P044357
  • GC01P044584
  • GC01P042699

Summaries for KLF17 Gene

GeneCards Summary for KLF17 Gene

KLF17 (Kruppel Like Factor 17) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is KLF5.

UniProtKB/Swiss-Prot for KLF17 Gene

  • Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5-CACCC-3 sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).

Gene Wiki entry for KLF17 Gene

Additional gene information for KLF17 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF17 Gene

Genomics for KLF17 Gene

GeneHancer (GH) Regulatory Elements for KLF17 Gene

Promoters and enhancers for KLF17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J044047 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 650.4 +5.0 5049 3.5 HDGF PKNOX1 ATF1 ARNT ARID4B TCF12 POLR2B CBX5 ARID2 ZNF143 KLF17 MED8 IPO13 LOC101929609 KDM4A SZT2 RPS8 ARTN HECTD3 ENSG00000230615
GH01J044044 Enhancer 0.9 ENCODE 650.7 +0.5 457 0.2 PKNOX1 ARNT TCF12 ZNF766 FOS NCOA1 ZNF592 MBD2 GMEB1 ZNF184 KLF17 DMAP1 SZT2 IPO13 LOC101929609 ENSG00000230615 ENSG00000227163
GH01J044118 Promoter 0.5 EPDnew 650.2 +75.0 75003 0.1 RN7SL479P KLF17 GC01M044123
GH01J044034 Enhancer 1.8 VISTA Ensembl ENCODE dbSUPER 5.2 -7.7 -7739 3 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT ZNF2 ZNF766 E2F8 ZNF143 DEK SZT2 RPS8 LOC101929609 PTCH2 ENSG00000230615 KLF17 SLC6A9
GH01J044068 Enhancer 0.8 Ensembl ENCODE 0.3 +24.8 24773 1 SP1 ZNF766 RXRA NR2F1 SMAD4 NR2F6 RBPJ SPI1 SLC6A9 ARTN ENSG00000227163 KLF17 ENSG00000230615
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLF17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLF17 gene promoter:
  • FOXD3
  • FOXO3b
  • FOXO3a
  • FOXO3
  • AREB6
  • FAC1
  • ISGF-3
  • COMP1
  • Bach1
  • FOXO4

Genomic Locations for KLF17 Gene

Genomic Locations for KLF17 Gene
chr1:44,043,927-44,135,140
(GRCh38/hg38)
Size:
91,214 bases
Orientation:
Plus strand
chr1:44,584,522-44,600,812
(GRCh37/hg19)
Size:
16,291 bases
Orientation:
Plus strand

Genomic View for KLF17 Gene

Genes around KLF17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF17 Gene

Proteins for KLF17 Gene

  • Protein details for KLF17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JT82-KLF17_HUMAN
    Recommended name:
    Krueppel-like factor 17
    Protein Accession:
    Q5JT82
    Secondary Accessions:
    • Q86VQ7
    • Q8N805

    Protein attributes for KLF17 Gene

    Size:
    389 amino acids
    Molecular mass:
    42577 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLF17 Gene

Post-translational modifications for KLF17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF17 Gene

Antibody Products

  • Abcam antibodies for KLF17
  • Boster Bio Antibodies for KLF17
  • Santa Cruz Biotechnology (SCBT) Antibodies for KLF17

No data available for DME Specific Peptides for KLF17 Gene

Domains & Families for KLF17 Gene

Gene Families for KLF17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KLF17 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KLF17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JT82

UniProtKB/Swiss-Prot:

KLF17_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF17: view

Function for KLF17 Gene

Molecular function for KLF17 Gene

UniProtKB/Swiss-Prot Function:
Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5-CACCC-3 sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).

Phenotypes From GWAS Catalog for KLF17 Gene

Gene Ontology (GO) - Molecular Function for KLF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity ISS --
GO:0005515 protein binding IPI 25416956
GO:0044212 transcription regulatory region DNA binding ISS --
genes like me logo Genes that share ontologies with KLF17: view
genes like me logo Genes that share phenotypes with KLF17: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLF17 Gene

Localization for KLF17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF17 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for KLF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with KLF17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLF17 Gene

Pathways & Interactions for KLF17 Gene

SuperPathways for KLF17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II ISS --
genes like me logo Genes that share ontologies with KLF17: view

No data available for Pathways by source and SIGNOR curated interactions for KLF17 Gene

Drugs & Compounds for KLF17 Gene

No Compound Related Data Available

Transcripts for KLF17 Gene

mRNA/cDNA for KLF17 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLF17 Gene

Kruppel-like factor 17:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLF17 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP2: - -
SP3:

Relevant External Links for KLF17 Gene

GeneLoc Exon Structure for
KLF17
ECgene alternative splicing isoforms for
KLF17

Expression for KLF17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLF17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF17 Gene

This gene is overexpressed in Testis (x29.8).

Protein differential expression in normal tissues from HIPED for KLF17 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLF17 Gene



Protein tissue co-expression partners for KLF17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLF17 Gene:

KLF17

SOURCE GeneReport for Unigene cluster for KLF17 Gene:

Hs.567674

Evidence on tissue expression from TISSUES for KLF17 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with KLF17: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF17 Gene

Orthologs for KLF17 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF17 34 33
  • 99.06 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KLF17 34 33
  • 78.57 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KLF17 33
  • 75.7 (n)
-- 34
  • 61 (a)
OneToMany
-- 34
  • 55 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Klf17 16 34 33
  • 65.86 (n)
rat
(Rattus norvegicus)
Mammalia Klf17 33
  • 65.84 (n)
oppossum
(Monodelphis domestica)
Mammalia KLF17 34
  • 20 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii AL929286.1 34
  • 19 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta btd 34
  • 13 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM101 36
Species where no ortholog for KLF17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLF17 Gene

ENSEMBL:
Gene Tree for KLF17 (if available)
TreeFam:
Gene Tree for KLF17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLF17: view image

Paralogs for KLF17 Gene

Paralogs for KLF17 Gene

Pseudogenes.org Pseudogenes for KLF17 Gene

genes like me logo Genes that share paralogs with KLF17: view

Variants for KLF17 Gene

Sequence variations from dbSNP and Humsavar for KLF17 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000004265 -- 44,132,209(+) G/T intron_variant
rs1000011096 -- 44,135,182(+) C/A downstream_transcript_variant
rs1000048994 -- 44,055,072(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000051772 -- 44,047,096(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000083723 -- 44,051,260(+) T/G 5_prime_UTR_variant, genic_upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KLF17 Gene

Variant ID Type Subtype PubMed ID
nsv829704 CNV loss 17160897

Variation tolerance for KLF17 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.86; 89.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLF17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF17

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF17 Gene

Disorders for KLF17 Gene

Additional Disease Information for KLF17

No disorders were found for KLF17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLF17 Gene

Publications for KLF17 Gene

  1. Human KLF17 is a new member of the Sp/KLF family of transcription factors. (PMID: 16460907) van Vliet J … Crossley M (Genomics 2006) 2 3 4 22 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. KLF17 attenuates estrogen receptor α-mediated signaling by impeding ERα function on chromatin and determines response to endocrine therapy. (PMID: 27107895) Ali A … Khan AA (Biochimica et biophysica acta 2016) 3 58

Products for KLF17 Gene

Sources for KLF17 Gene

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