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Aliases for AADACL3 Gene

Aliases for AADACL3 Gene

  • Arylacetamide Deacetylase Like 3 2 3 5
  • Arylacetamide Deacetylase-Like 3 3
  • EC 3.1.1.- 4

External Ids for AADACL3 Gene

Previous GeneCards Identifiers for AADACL3 Gene

  • GC01P012698
  • GC01P011931

Summaries for AADACL3 Gene

GeneCards Summary for AADACL3 Gene

AADACL3 (Arylacetamide Deacetylase Like 3) is a Protein Coding gene. Diseases associated with AADACL3 include Mite Infestation and Norwegian Scabies. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is AADACL4.

Additional gene information for AADACL3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AADACL3 Gene

Genomics for AADACL3 Gene

GeneHancer (GH) Regulatory Elements for AADACL3 Gene

Promoters and enhancers for AADACL3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J012714 Enhancer 0.4 ENCODE 650.7 -1.0 -961 2.1 ZNF148 POLR2A AADACL3 ENSG00000226166
GH01J012746 Promoter 0.9 EPDnew 0.3 +30.1 30066 0.1 HDAC1 RFX1 MAFG ZEB2 BMI1 EP300 ZNF217 ADNP RUNX3 TRIM28 C1orf158 AADACL3
GH01J012711 Enhancer 0.3 ENCODE 0.7 -3.9 -3894 2.1 PRDM10 AADACL3 ENSG00000226166
GH01J012707 Enhancer 0.4 ENCODE 0.4 -7.1 -7140 2.7 HLF ZFP64 AADACL3 ENSG00000226166
GH01J012710 Enhancer 0.2 ENCODE 0.4 -5.3 -5322 0.3 AADACL3 ENSG00000226166
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AADACL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AADACL3 gene promoter:
  • ATF6
  • AML1a
  • STAT3
  • LyF-1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • STAT1beta
  • STAT1alpha

Genomic Locations for AADACL3 Gene

Genomic Locations for AADACL3 Gene
12,645 bases
Plus strand
12,609 bases
Plus strand

Genomic View for AADACL3 Gene

Genes around AADACL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AADACL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AADACL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AADACL3 Gene

Proteins for AADACL3 Gene

  • Protein details for AADACL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arylacetamide deacetylase-like 3
    Protein Accession:
    Secondary Accessions:
    • B3KXR9
    • Q5VUY1

    Protein attributes for AADACL3 Gene

    407 amino acids
    Molecular mass:
    46155 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAG54581.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for AADACL3 Gene

Post-translational modifications for AADACL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AADACL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AADACL3 Gene

Domains & Families for AADACL3 Gene

Gene Families for AADACL3 Gene

Protein Domains for AADACL3 Gene

Suggested Antigen Peptide Sequences for AADACL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GDXG lipolytic enzyme family.
  • Belongs to the GDXG lipolytic enzyme family.
genes like me logo Genes that share domains with AADACL3: view

Function for AADACL3 Gene

Enzyme Numbers (IUBMB) for AADACL3 Gene

Phenotypes From GWAS Catalog for AADACL3 Gene

Gene Ontology (GO) - Molecular Function for AADACL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IBA --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with AADACL3: view

Animal Model Products

Clone Products

No data available for Molecular function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AADACL3 Gene

Localization for AADACL3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AADACL3 gene
Compartment Confidence
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for AADACL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AADACL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for AADACL3 Gene

Pathways & Interactions for AADACL3 Gene

SuperPathways for AADACL3 Gene

No Data Available

Interacting Proteins for AADACL3 Gene

Gene Ontology (GO) - Biological Process for AADACL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009056 catabolic process IBA --
genes like me logo Genes that share ontologies with AADACL3: view

No data available for Pathways by source and SIGNOR curated interactions for AADACL3 Gene

Drugs & Compounds for AADACL3 Gene

No Compound Related Data Available

Transcripts for AADACL3 Gene

mRNA/cDNA for AADACL3 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AADACL3 Gene

Arylacetamide deacetylase-like 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AADACL3 Gene

No ASD Table

Relevant External Links for AADACL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AADACL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AADACL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AADACL3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x33.9) and Skin - Sun Exposed (Lower leg) (x14.2).

NURSA nuclear receptor signaling pathways regulating expression of AADACL3 Gene:


SOURCE GeneReport for Unigene cluster for AADACL3 Gene:

genes like me logo Genes that share expression patterns with AADACL3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AADACL3 Gene

Orthologs for AADACL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for AADACL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AADACL3 34 33
  • 98.57 (n)
(Bos Taurus)
Mammalia LOC530613 33
  • 76.86 (n)
  • 60 (a)
(Canis familiaris)
Mammalia AADACL3 34 33
  • 76.67 (n)
(Mus musculus)
Mammalia Aadacl3 16 34 33
  • 70.79 (n)
(Rattus norvegicus)
Mammalia Aadacl3 33
  • 70.02 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 44 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 37 (a)
(Gallus gallus)
Aves -- 34
  • 43 (a)
-- 34
  • 39 (a)
-- 34
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
-- 34
  • 38 (a)
-- 34
  • 38 (a)
-- 34
  • 37 (a)
-- 34
  • 37 (a)
-- 34
  • 37 (a)
-- 34
  • 34 (a)
(Danio rerio)
Actinopterygii aadacl4 34
  • 32 (a)
(Caenorhabditis elegans)
Secernentea trcs-1 34
  • 20 (a)
Y43F8A.3 34
  • 20 (a)
T09B9.1 34
  • 20 (a)
F16F9.4 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
Species where no ortholog for AADACL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AADACL3 Gene

Gene Tree for AADACL3 (if available)
Gene Tree for AADACL3 (if available)
Evolutionary constrained regions (ECRs) for AADACL3: view image

Paralogs for AADACL3 Gene

Paralogs for AADACL3 Gene

(4) SIMAP similar genes for AADACL3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AADACL3: view

Variants for AADACL3 Gene

Sequence variations from dbSNP and Humsavar for AADACL3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000046975 -- 12,726,397(+) G/A 3_prime_UTR_variant, non_coding_transcript_variant
rs1000349786 -- 12,725,224(+) A/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000435954 -- 12,724,965(+) T/G intron_variant
rs1000932118 -- 12,714,201(+) G/T upstream_transcript_variant
rs1001471388 -- 12,714,433(+) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for AADACL3 Gene

Variant ID Type Subtype PubMed ID
nsv1011540 CNV loss 25217958
nsv466394 CNV gain 19166990
nsv545444 CNV loss 21841781
nsv545445 CNV gain 21841781
nsv999658 CNV gain 25217958

Variation tolerance for AADACL3 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.69; 73.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AADACL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AADACL3 Gene

Disorders for AADACL3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for AADACL3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mite infestation
  • mite infestations
norwegian scabies
  • crusted scabies
parasitic ectoparasitic infectious disease
  • ectoparasitism
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for AADACL3

genes like me logo Genes that share disorders with AADACL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AADACL3 Gene

Publications for AADACL3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for AADACL3 Gene

Sources for AADACL3 Gene

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