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Aliases for TMEM219 Gene

Aliases for TMEM219 Gene

  • Transmembrane Protein 219 2 3 4 5
  • IGFBP-3R 3 4
  • Insulin-Like Growth Factor-Binding Protein 3 Receptor 3
  • Testicular Tissue Protein Li 203 3

External Ids for TMEM219 Gene

Previous GeneCards Identifiers for TMEM219 Gene

  • GC16P029880
  • GC16P027634

Summaries for TMEM219 Gene

GeneCards Summary for TMEM219 Gene

TMEM219 (Transmembrane Protein 219) is a Protein Coding gene. Among its related pathways are Gene Expression and TP53 Regulates Transcription of Cell Death Genes.

UniProtKB/Swiss-Prot for TMEM219 Gene

  • Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.

Additional gene information for TMEM219 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM219 Gene

Genomics for TMEM219 Gene

GeneHancer (GH) Regulatory Elements for TMEM219 Gene

Promoters and enhancers for TMEM219 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J029961 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 662.6 +21.5 21502 2.5 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 POLR2B TMEM219 PIR61167 INO80E ENSG00000260853 ENSG00000260367 SRCAP SPNS1 SMG1P5 SMG1P2 CA5AP1
GH16J029819 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.4 -118.0 -117971 7.5 HDGF PKNOX1 CLOCK SIN3A ZNF48 YY1 GLIS2 ZNF143 ZFP91 FOS MVP ENSG00000238045 GC16M029840 INO80E ATXN2L SRCAP FBRS ENSG00000260853 RNF40 NPIPB12
GH16J029972 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 11.8 +34.7 34672 6.1 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TAOK2 INO80E SETD1A SRCAP NPIPB12 NPIPB13 ENSG00000260367 ZNF764 BCL7C SMG1P5
GH16J029898 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.1 -40.3 -40337 3.8 PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 INO80E ASPHD1 GC16M029899 GC16M029900 SEZ6L2 SMG1P5 SMG1P2 SRCAP ZNF785 ENSG00000260853
GH16J029862 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 -77.8 -77763 2.1 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC CDIPTOSP CDIPT ENSG00000278713 SRCAP INO80E SPNS1 ENSG00000260853 NFATC2IP RNF40 SMG1P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM219 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM219 gene promoter:
  • p53
  • Pax-3
  • AREB6
  • GCNF-2
  • GCNF-1
  • GCNF
  • Cdc5
  • LUN-1
  • CHOP-10

Genomic Locations for TMEM219 Gene

Genomic Locations for TMEM219 Gene
32,168 bases
Plus strand
32,168 bases
Plus strand

Genomic View for TMEM219 Gene

Genes around TMEM219 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM219 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM219 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM219 Gene

Proteins for TMEM219 Gene

  • Protein details for TMEM219 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin-like growth factor-binding protein 3 receptor
    Protein Accession:
    Secondary Accessions:
    • D5FK14
    • Q8WVV8

    Protein attributes for TMEM219 Gene

    240 amino acids
    Molecular mass:
    25724 Da
    Quaternary structure:
    • Interacts with IGFBP3. Interacts with CASP8.

neXtProt entry for TMEM219 Gene

Post-translational modifications for TMEM219 Gene

  • Glycosylation at posLast=167167, isoforms=101, and posLast=7373
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM219 Gene

Domains & Families for TMEM219 Gene

Gene Families for TMEM219 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM219 Gene


Suggested Antigen Peptide Sequences for TMEM219 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM219: view

No data available for UniProtKB/Swiss-Prot for TMEM219 Gene

Function for TMEM219 Gene

Molecular function for TMEM219 Gene

UniProtKB/Swiss-Prot Function:
Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.

Phenotypes From GWAS Catalog for TMEM219 Gene

genes like me logo Genes that share phenotypes with TMEM219: view

Animal Models for TMEM219 Gene

MGI Knock Outs for TMEM219:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM219 Gene

Localization for TMEM219 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM219 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM219 gene
Compartment Confidence
plasma membrane 5
extracellular 3

Gene Ontology (GO) - Cellular Components for TMEM219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM219: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM219 Gene

Pathways & Interactions for TMEM219 Gene

genes like me logo Genes that share pathways with TMEM219: view

Interacting Proteins for TMEM219 Gene

Gene Ontology (GO) - Biological Process for TMEM219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0042981 regulation of apoptotic process TAS --
genes like me logo Genes that share ontologies with TMEM219: view

No data available for SIGNOR curated interactions for TMEM219 Gene

Drugs & Compounds for TMEM219 Gene

No Compound Related Data Available

Transcripts for TMEM219 Gene

mRNA/cDNA for TMEM219 Gene

Unigene Clusters for TMEM219 Gene

Transmembrane protein 219:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM219 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP3: - - -

Relevant External Links for TMEM219 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM219 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM219 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM219 Gene

This gene is overexpressed in Placenta (37.4) and Pancreas (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM219 Gene

Protein tissue co-expression partners for TMEM219 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM219 Gene:


SOURCE GeneReport for Unigene cluster for TMEM219 Gene:


mRNA Expression by UniProt/SwissProt for TMEM219 Gene:

Tissue specificity: Widely expressed in normal tissues but suppressed in prostate and breast tumor.

Evidence on tissue expression from TISSUES for TMEM219 Gene

  • Nervous system(4.6)
  • Lung(4.4)
genes like me logo Genes that share expression patterns with TMEM219: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM219 Gene

Orthologs for TMEM219 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM219 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM219 34 33
  • 99.72 (n)
(Canis familiaris)
Mammalia TMEM219 34 33
  • 90.42 (n)
(Bos Taurus)
Mammalia TMEM219 34 33
  • 89.68 (n)
(Mus musculus)
Mammalia Tmem219 16 34 33
  • 84.86 (n)
(Rattus norvegicus)
Mammalia Tmem219 33
  • 83.54 (n)
(Monodelphis domestica)
Mammalia TMEM219 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM219 34
  • 58 (a)
Species where no ortholog for TMEM219 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM219 Gene

Gene Tree for TMEM219 (if available)
Gene Tree for TMEM219 (if available)
Evolutionary constrained regions (ECRs) for TMEM219: view image

Paralogs for TMEM219 Gene

(1) SIMAP similar genes for TMEM219 Gene using alignment to 6 proteins:

  • TM219_HUMAN
  • I3L2J7_HUMAN
  • I3L2P0_HUMAN
  • I3L4B3_HUMAN
genes like me logo Genes that share paralogs with TMEM219: view

No data available for Paralogs for TMEM219 Gene

Variants for TMEM219 Gene

Sequence variations from dbSNP and Humsavar for TMEM219 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000050047 -- 29,970,514(+) T/C intron_variant
rs1000106990 -- 29,969,317(+) C/CC intron_variant
rs1000177830 -- 29,963,944(+) A/G intron_variant
rs1000904307 -- 29,964,451(+) C/T intron_variant
rs1000999790 -- 29,969,097(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM219 Gene

Variant ID Type Subtype PubMed ID
esv29470 CNV loss 19812545
esv3638377 CNV loss 21293372

Variation tolerance for TMEM219 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM219 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM219 Gene

Disorders for TMEM219 Gene

Additional Disease Information for TMEM219

No disorders were found for TMEM219 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM219 Gene

Publications for TMEM219 Gene

  1. Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer. (PMID: 20353938) Ingermann AR … Oh Y (The Journal of biological chemistry 2010) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for TMEM219 Gene

Sources for TMEM219 Gene

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