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Aliases for ZG16B Gene

Aliases for ZG16B Gene

  • Zymogen Granule Protein 16B 2 3 5
  • Jacalin-Like Lectin Domain Containing 2 2 3
  • Pancreatic Adenocarcinoma Upregulated Factor 3
  • Zymogen Granule Protein 16 Homolog B (Rat) 2
  • Zymogen Granule Protein 16 Homolog B 3
  • Endocrine And Exocrine Protein 3
  • HRPE773 3
  • PRO1567 3
  • JCLN2 3
  • EECP 3
  • PAUF 3

External Ids for ZG16B Gene

Previous GeneCards Identifiers for ZG16B Gene

  • GC16P002821
  • GC16P002881
  • GC16P002832
  • GC16P002836
  • GC16P002895
  • GC16P002941
  • GC16P002975

Summaries for ZG16B Gene

GeneCards Summary for ZG16B Gene

ZG16B (Zymogen Granule Protein 16B) is a Protein Coding gene. Diseases associated with ZG16B include Branch Retinal Artery Occlusion. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is ZG16.

Gene Wiki entry for ZG16B Gene

Additional gene information for ZG16B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZG16B Gene

Genomics for ZG16B Gene

GeneHancer (GH) Regulatory Elements for ZG16B Gene

Promoters and enhancers for ZG16B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J002829 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 685.4 +0.0 32 1.4 ELF3 PKNOX1 FOXA2 ARID4B ZBTB7B ZNF48 ZSCAN9 RARA MIXL1 ELF1 ZG16B PRSS30P
GH16J002835 Enhancer 1.3 Ensembl ENCODE dbSUPER 19.5 +6.3 6291 2.4 ARID4B SIN3A FOS SP3 TSHZ1 KAT8 SREBF1 SMARCA4 GLIS1 MXD3 SRRM2 ZNF263 ZG16B SNORA64 ENSG00000255513 LOC105371055 THOC6 ZNF598 E4F1 TRAF7
GH16J002867 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 12.4 +38.3 38307 2 MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ZNF610 GLIS1 LOC101929566 GC16P003535 ENSG00000200059 ENSG00000261240 FLYWCH2 ZG16B FLYWCH1 PRSS41 SNORA3C PRSS33
GH16J002816 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 8.1 -12.6 -12643 1.7 HDAC1 ATF1 RB1 NFIB ZBTB40 EGR1 CREM SMARCC1 NCOA1 SMARCB1 PRSS21 ZG16B PRSS41 EIF1P4
GH16J002822 Enhancer 0.5 ENCODE 23.2 -7.0 -6953 0.8 CTCF ZNF654 SMC3 REST ZNF600 ZBTB33 RAD21 EIF1P4 ZG16B PRSS21
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZG16B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZG16B gene promoter:
  • Roaz
  • RORalpha1
  • NRSF form 2
  • NRSF form 1
  • Arnt
  • En-1
  • NF-1
  • AP-1

Genomic Locations for ZG16B Gene

Genomic Locations for ZG16B Gene
9,417 bases
Plus strand
8,798 bases
Plus strand

Genomic View for ZG16B Gene

Genes around ZG16B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZG16B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZG16B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZG16B Gene

Proteins for ZG16B Gene

  • Protein details for ZG16B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zymogen granule protein 16 homolog B
    Protein Accession:
    Secondary Accessions:
    • A6NIY1
    • B2R4F6
    • Q6UW28

    Protein attributes for ZG16B Gene

    208 amino acids
    Molecular mass:
    22739 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ89380.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG34753.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZG16B Gene

neXtProt entry for ZG16B Gene

Post-translational modifications for ZG16B Gene

  • Glycosylation at isoforms=197
  • Modification sites at PhosphoSitePlus

Other Protein References for ZG16B Gene

No data available for DME Specific Peptides for ZG16B Gene

Domains & Families for ZG16B Gene

Gene Families for ZG16B Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ZG16B Gene

Suggested Antigen Peptide Sequences for ZG16B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the jacalin lectin family.
  • Belongs to the jacalin lectin family.
genes like me logo Genes that share domains with ZG16B: view

Function for ZG16B Gene

Gene Ontology (GO) - Molecular Function for ZG16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ZG16B: view
genes like me logo Genes that share phenotypes with ZG16B: view

Animal Model Products

CRISPR Products

miRNA for ZG16B Gene

miRTarBase miRNAs that target ZG16B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZG16B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZG16B Gene

Localization for ZG16B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZG16B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZG16B gene
Compartment Confidence
extracellular 5
mitochondrion 2
nucleus 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZG16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space HDA 16502470
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with ZG16B: view

Pathways & Interactions for ZG16B Gene

SuperPathways for ZG16B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZG16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis HEP 23580065
genes like me logo Genes that share ontologies with ZG16B: view

No data available for Pathways by source and SIGNOR curated interactions for ZG16B Gene

Drugs & Compounds for ZG16B Gene

No Compound Related Data Available

Transcripts for ZG16B Gene

mRNA/cDNA for ZG16B Gene

Unigene Clusters for ZG16B Gene

Zymogen granule protein 16B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZG16B

Alternative Splicing Database (ASD) splice patterns (SP) for ZG16B Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - -
SP2: -
SP4: -

Relevant External Links for ZG16B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZG16B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZG16B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZG16B Gene

This gene is overexpressed in Minor Salivary Gland (x52.0).

Protein differential expression in normal tissues from HIPED for ZG16B Gene

This gene is overexpressed in Skin (26.6), Salivary gland (23.0), and Saliva (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZG16B Gene

NURSA nuclear receptor signaling pathways regulating expression of ZG16B Gene:


SOURCE GeneReport for Unigene cluster for ZG16B Gene:


Evidence on tissue expression from TISSUES for ZG16B Gene

  • Heart(2.4)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with ZG16B: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZG16B Gene

Orthologs for ZG16B Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZG16B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZG16B 34 33
  • 99.2 (n)
(Bos Taurus)
Mammalia ZG16B 33
  • 68.1 (n)
-- 34
  • 52 (a)
-- 34
  • 45 (a)
-- 34
  • 41 (a)
(Canis familiaris)
Mammalia ZG16B 34 33
  • 64.52 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 29 (a)
-- 34
  • 29 (a)
(Mus musculus)
Mammalia Sbp 34
  • 24 (a)
Sbpl 34
  • 20 (a)
Species where no ortholog for ZG16B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZG16B Gene

Gene Tree for ZG16B (if available)
Gene Tree for ZG16B (if available)
Evolutionary constrained regions (ECRs) for ZG16B: view image

Paralogs for ZG16B Gene

Paralogs for ZG16B Gene

(3) SIMAP similar genes for ZG16B Gene using alignment to 3 proteins:

  • I3L1H9_HUMAN
  • I3L3X0_HUMAN
genes like me logo Genes that share paralogs with ZG16B: view

Variants for ZG16B Gene

Sequence variations from dbSNP and Humsavar for ZG16B Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000410125 -- 2,830,418(+) C/G coding_sequence_variant, missense_variant
rs1000879846 -- 2,830,655(+) A/C intron_variant
rs1002781287 -- 2,831,142(+) A/G intron_variant
rs1003121970 -- 2,831,938(+) T/C coding_sequence_variant, missense_variant
rs1003352052 -- 2,828,774(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZG16B Gene

Variant ID Type Subtype PubMed ID
esv2663371 CNV deletion 23128226
nsv952905 CNV deletion 24416366

Variation tolerance for ZG16B Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZG16B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZG16B Gene

Disorders for ZG16B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZG16B Gene - From: DISEASES

Disorder Aliases PubMed IDs
branch retinal artery occlusion
  • arterial retinal branch occlusion
- elite association - COSMIC cancer census association via MalaCards
Search ZG16B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZG16B

genes like me logo Genes that share disorders with ZG16B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZG16B Gene

Publications for ZG16B Gene

  1. Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related β-prism fold. (PMID: 21110947) Kanagawa M … Yamaguchi Y (Biochemical and biophysical research communications 2011) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. Mass spectrometry allows direct identification of proteins in large genomes. (PMID: 11678034) Küster B … Mann M (Proteomics 2001) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZG16B Gene

Sources for ZG16B Gene

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