Aliases for CLTB Gene
External Ids for CLTB Gene
Previous GeneCards Identifiers for CLTB Gene
Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLTB Gene
CLTB (Clathrin Light Chain B) is a Protein Coding gene. Diseases associated with CLTB include Leber Congenital Amaurosis 6 and Leber Congenital Amaurosis. Among its related pathways are wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF) and Signaling by Wnt. Gene Ontology (GO) annotations related to this gene include structural molecule activity and peptide binding. An important paralog of this gene is CLTA.
UniProtKB/Swiss-Prot for CLTB Gene
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.