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Aliases for CLPS Gene

Aliases for CLPS Gene

  • Colipase 2 3 3 5
  • Colipase, Pancreatic 2 3
  • Pancreatic Colipase Preproprotein 3
  • Pancreatic Colipase 2

External Ids for CLPS Gene

Previous GeneCards Identifiers for CLPS Gene

  • GC06M035764
  • GC06M035809
  • GC06M035870
  • GC06M035480
  • GC06M035765
  • GC06M035867
  • GC06M035927
  • GC06M036109
  • GC06M036305
  • GC06M036672
  • GC06M037025
  • GC06M037375
  • GC06M037731
  • GC06M038077

Summaries for CLPS Gene

Entrez Gene Summary for CLPS Gene

  • The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for CLPS Gene

CLPS (Colipase) is a Protein Coding gene. Diseases associated with CLPS include Johanson-Blizzard Syndrome and Obsessive-Compulsive Personality Disorder. Among its related pathways are Lipoprotein metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include enzyme activator activity.

UniProtKB/Swiss-Prot for CLPS Gene

  • Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.

  • Enterostatin has a biological activity as a satiety signal.

Gene Wiki entry for CLPS Gene

Additional gene information for CLPS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLPS Gene

Genomics for CLPS Gene

GeneHancer (GH) Regulatory Elements for CLPS Gene

Promoters and enhancers for CLPS Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J035797 Promoter 0.8 EPDnew 650.7 +0.0 1 0.1 TCF12 ZFHX2 POLR2A BHLHE40 CBFA2T3 CBFA2T2 EGR2 CLPS LHFPL5 CLPSL1 GC06M038959
GH06J035776 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 12.2 +20.7 20706 0.7 CLOCK SIN3A KLF14 GLIS2 ZNF366 EGR1 ZNF280D USF2 ZNF398 ELF1 CLPSL2 CLPS ENSG00000232909 ARMC12 FKBP5 CLPSL1 GC06M038959
GH06J036289 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 9.6 -494.0 -494008 3 PKNOX1 ZNF766 FOS ATF7 ZNF623 ATF4 SMARCA4 NBN KDM1A BRD4 PNPLA1 C6orf222 CLPS BRPF3 MAPK13 LOC105375036
GH06J035738 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.6 +57.4 57404 2.9 ELF3 FOXA2 ZFP64 ARID4B RAD21 ETS1 YY1 TCF12 ZNF614 EGR1 ENSG00000212579 CLPS MAPK13 TEAD3 SLC26A8 ENSG00000228559 LOC285847 ENSG00000232909 ARMC12 LOC100652794
GH06J035973 Enhancer 1 ENCODE 10.6 -176.5 -176501 1.2 PKNOX1 ATF1 FOXA2 MLX ARNT ARID4B DMAP1 IRF4 ETS1 YY1 SRPK1 SLC26A8 MAPK13 CLPS ARMC12 ENSG00000232909 FKBP5 LOC105375035 DPRXP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLPS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLPS gene promoter:
  • NF-kappaB1
  • NF-kappaB
  • NRSF form 2
  • NRSF form 1
  • MRF-2
  • GATA-1
  • TGIF
  • RP58
  • Ik-2
  • NF-1

Genomic Locations for CLPS Gene

Genomic Locations for CLPS Gene
2,363 bases
Minus strand
2,344 bases
Minus strand

Genomic View for CLPS Gene

Genes around CLPS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLPS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLPS Gene

Proteins for CLPS Gene

  • Protein details for CLPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5T9G7
    • Q5U809

    Protein attributes for CLPS Gene

    112 amino acids
    Molecular mass:
    11954 Da
    Quaternary structure:
    • Forms a 1:1 stoichiometric complex with pancreatic lipase.

neXtProt entry for CLPS Gene

Post-translational modifications for CLPS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLPS Gene

No data available for DME Specific Peptides for CLPS Gene

Domains & Families for CLPS Gene

Gene Families for CLPS Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CLPS Gene

Suggested Antigen Peptide Sequences for CLPS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the colipase family.
  • Belongs to the colipase family.
genes like me logo Genes that share domains with CLPS: view

Function for CLPS Gene

Molecular function for CLPS Gene

UniProtKB/Swiss-Prot Function:
Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
UniProtKB/Swiss-Prot Function:
Enterostatin has a biological activity as a satiety signal.
GENATLAS Biochemistry:

Phenotypes From GWAS Catalog for CLPS Gene

Gene Ontology (GO) - Molecular Function for CLPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008047 enzyme activator activity IEA --
genes like me logo Genes that share ontologies with CLPS: view
genes like me logo Genes that share phenotypes with CLPS: view

Animal Models for CLPS Gene

MGI Knock Outs for CLPS:
  • Clps Clps<tm1Lowe>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLPS

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CLPS Gene

Localization for CLPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLPS Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLPS gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CLPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with CLPS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLPS Gene

Pathways & Interactions for CLPS Gene

genes like me logo Genes that share pathways with CLPS: view

Gene Ontology (GO) - Biological Process for CLPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006629 lipid metabolic process NAS 2045105
GO:0007586 digestion IEA --
GO:0016042 lipid catabolic process IEA --
GO:0032094 response to food IBA --
genes like me logo Genes that share ontologies with CLPS: view

No data available for SIGNOR curated interactions for CLPS Gene

Drugs & Compounds for CLPS Gene

(9) Drugs for CLPS Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(Hydroxyethyloxy)Tri(Ethyloxy)Octane Experimental Pharma Target 0
B-nonylglucoside Experimental Pharma Target 0

(12) Additional Compounds for CLPS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CLPS: view

Transcripts for CLPS Gene

mRNA/cDNA for CLPS Gene

Unigene Clusters for CLPS Gene

Colipase, pancreatic:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLPS

Alternative Splicing Database (ASD) splice patterns (SP) for CLPS Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: -
SP3: - - -

Relevant External Links for CLPS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLPS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLPS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLPS Gene

This gene is overexpressed in Pancreas (x52.9).

Protein differential expression in normal tissues from HIPED for CLPS Gene

This gene is overexpressed in Pancreatic juice (56.4) and Pancreas (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLPS Gene

Protein tissue co-expression partners for CLPS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLPS Gene:


SOURCE GeneReport for Unigene cluster for CLPS Gene:


mRNA Expression by UniProt/SwissProt for CLPS Gene:

Tissue specificity: Expressed by the pancreas.

Evidence on tissue expression from TISSUES for CLPS Gene

  • Pancreas(4.9)
  • Intestine(2.5)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with CLPS: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CLPS Gene

Orthologs for CLPS Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLPS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLPS 34 33
  • 99.7 (n)
(Canis familiaris)
Mammalia CLPS 34 33
  • 85.12 (n)
(Bos Taurus)
Mammalia CLPS 34 33
  • 81.85 (n)
(Mus musculus)
Mammalia Clps 16 34 33
  • 81.25 (n)
(Rattus norvegicus)
Mammalia Clps 33
  • 80 (n)
(Monodelphis domestica)
Mammalia CLPS 34
  • 75 (a)
(Gallus gallus)
Aves CLPS 34 33
  • 70.92 (n)
(Anolis carolinensis)
Reptilia CLPS 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia clps 33
  • 56.92 (n)
Species where no ortholog for CLPS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLPS Gene

Gene Tree for CLPS (if available)
Gene Tree for CLPS (if available)
Evolutionary constrained regions (ECRs) for CLPS: view image

Paralogs for CLPS Gene

(1) SIMAP similar genes for CLPS Gene using alignment to 2 proteins:

  • Q5U808_HUMAN
genes like me logo Genes that share paralogs with CLPS: view

No data available for Paralogs for CLPS Gene

Variants for CLPS Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CLPS Gene

Variant Cys-109 is statistically significantly associated with an increased risk of type 2 diabetes.

Sequence variations from dbSNP and Humsavar for CLPS Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs2766595 benign, not specified 35,796,793(-) G/A intron_variant
rs1000473684 -- 35,798,989(-) T/C upstream_transcript_variant
rs1000840014 -- 35,795,736(-) C/A coding_sequence_variant, intron_variant, missense_variant
rs1000953974 -- 35,795,606(-) C/T intron_variant
rs1002846308 -- 35,797,786(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CLPS Gene

Variant ID Type Subtype PubMed ID
dgv1043n67 CNV gain 20364138
dgv10630n54 CNV gain 21841781
dgv10631n54 CNV loss 21841781
dgv10632n54 CNV loss 21841781
dgv1177e214 CNV gain 21293372
dgv156e180 CNV gain 20482838
dgv3300n106 CNV duplication 24896259
dgv3489e59 CNV duplication 20981092
dgv3490e59 CNV tandem duplication 20981092
dgv3491e59 CNV duplication 20981092
esv25108 CNV gain 19812545
esv2759420 CNV gain 17122850
esv2860458 CNV duplication 24192839
esv33535 CNV gain 17666407
esv3608689 CNV gain 21293372
esv3890842 CNV gain 25118596
esv990474 CNV insertion 20482838
nsv1077999 CNV duplication 25765185
nsv1143148 CNV tandem duplication 24896259
nsv1149062 CNV duplication 26484159
nsv428143 CNV gain 18775914
nsv511122 OTHER complex 20534489
nsv513737 CNV insertion 21212237
nsv5259 CNV insertion 18451855
nsv602938 CNV gain+loss 21841781
nsv602939 CNV gain 21841781
nsv602940 CNV gain 21841781
nsv602944 CNV loss 21841781
nsv602945 CNV loss 21841781
nsv7891 CNV gain 18304495
nsv819076 CNV gain 19587683
nsv821646 CNV loss 15273396
nsv970364 CNV duplication 23825009

Variation tolerance for CLPS Gene

Residual Variation Intolerance Score: 78.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLPS Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for CLPS Gene

MalaCards: The human disease database

(3) MalaCards diseases for CLPS Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
johanson-blizzard syndrome
  • jbs
obsessive-compulsive personality disorder
  • anankastic personality disorder
orofaciodigital syndrome i
  • ofd1
- elite association - COSMIC cancer census association via MalaCards
Search CLPS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CLPS

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CLPS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLPS Gene

Publications for CLPS Gene

  1. Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations. (PMID: 16189801) Lindner I … Schrezenmeir J (Molecular nutrition & food research 2005) 3 4 22 44 58
  2. Genetic variability of procolipase associates with altered insulin secretion in non-diabetic Caucasians. (PMID: 18726866) Weyrich P … Häring HU (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2009) 3 22 44 58
  3. Procolipase gene: no association with early-onset obesity or fat intake. (PMID: 20054203) Wermter AK … Hebebrand J (Obesity facts 2009) 3 22 44 58
  4. The human colipase gene: isolation, chromosomal location, and tissue-specific expression. (PMID: 1643046) Sims HF … Lowe ME (Biochemistry 1992) 3 4 22 58
  5. Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter. (PMID: 2045105) Davis RC … Lusis AJ (Genomics 1991) 2 3 22 58

Products for CLPS Gene

Sources for CLPS Gene

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