Aliases for TMC2 Gene
External Ids for TMC2 Gene
Previous HGNC Symbols for TMC2 Gene
Previous GeneCards Identifiers for TMC2 Gene
This gene encodes a transmembrane protein that is necesssary for mechanotransduction in cochlear hair cells of the inner ear. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Aug 2015]
GeneCards Summary for TMC2 Gene
TMC2 (Transmembrane Channel Like 2) is a Protein Coding gene. Diseases associated with TMC2 include Deafness, Autosomal Dominant 36 and Autosomal Dominant Nonsyndromic Deafness. Gene Ontology (GO) annotations related to this gene include voltage-gated calcium channel activity. An important paralog of this gene is TMC1.
UniProtKB/Swiss-Prot for TMC2 Gene
Probable ion channel required for the normal function of cochlear hair cells (PubMed:11850618). Component of the hair cells mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity).