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Aliases for TAGAP Gene

Aliases for TAGAP Gene

  • T Cell Activation RhoGTPase Activating Protein 2 3
  • T-Cell Activation RhoGTPase Activating Protein 2 5
  • TAGAP1 3 4
  • T-Cell Activation Rho GTPase-Activating Protein 3
  • T-Cell Activation GTPase Activating Protein 2
  • T-Cell Activation GTPase-Activating Protein 4
  • ARHGAP47 3
  • FKSG15 3
  • IDDM21 3

External Ids for TAGAP Gene

Previous GeneCards Identifiers for TAGAP Gene

  • GC06M158897
  • GC06M159329
  • GC06M159365
  • GC06M159426
  • GC06M159375
  • GC06M159457
  • GC06M156926

Summaries for TAGAP Gene

Entrez Gene Summary for TAGAP Gene

  • This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for TAGAP Gene

TAGAP (T Cell Activation RhoGTPase Activating Protein) is a Protein Coding gene. Diseases associated with TAGAP include Diabetes Mellitus, Insulin-Dependent, 21 and Auditory Agnosia. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGAP20.

UniProtKB/Swiss-Prot for TAGAP Gene

  • May function as a GTPase-activating protein and may play important roles during T-cell activation.

Additional gene information for TAGAP Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAGAP Gene

Genomics for TAGAP Gene

GeneHancer (GH) Regulatory Elements for TAGAP Gene

Promoters and enhancers for TAGAP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I159035 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 568.5 +4.2 4154 10.1 HDGF PKNOX1 SMAD1 ZNF2 IRF4 ZNF207 ZNF143 ATF7 RUNX3 JUNB TAGAP RSPH3 LOC105378083 SYTL3 DYNLT1 GC06P159017
GH06I159098 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 41.3 -53.9 -53903 1.8 BACH1 ZMYM3 EBF1 BMI1 FOXK2 ATF7 ETV6 IKZF2 RUNX3 SRF TAGAP RSPH3 SYTL3 DYNLT1 ENSG00000224478 ENSG00000226032
GH06I159060 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 26.4 -17.9 -17864 4.8 SCRT1 PKNOX1 MAX MITF POLR2A SCRT2 ZNF548 RUNX3 SPI1 TAGAP WTAP DYNLT1 SYTL3 ENSG00000226032 LOC105378083
GH06I159103 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.4 -62.0 -61951 6.5 HDGF PKNOX1 ATF1 FOXA2 IRF4 ARID2 ZNF143 FOS ATF7 RUNX3 ENSG00000224478 TAGAP RSPH3 EZR ENSG00000226032
GH06I159093 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 21.5 -49.8 -49808 2.8 CTCF EBF1 KLF5 RELA FOXK2 POLR2A ATF7 IKZF2 SRF ZNF687 TAGAP RSPH3 DYNLT1 ENSG00000224478 ENSG00000226032
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TAGAP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAGAP gene promoter:

Genomic Locations for TAGAP Gene

Genomic Locations for TAGAP Gene
chr6:159,034,468-159,045,152
(GRCh38/hg38)
Size:
10,685 bases
Orientation:
Minus strand
chr6:159,455,500-159,466,184
(GRCh37/hg19)

Genomic View for TAGAP Gene

Genes around TAGAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAGAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAGAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAGAP Gene

Proteins for TAGAP Gene

  • Protein details for TAGAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N103-TAGAP_HUMAN
    Recommended name:
    T-cell activation Rho GTPase-activating protein
    Protein Accession:
    Q8N103
    Secondary Accessions:
    • Q2NKM8
    • Q8NI40
    • Q96KZ2
    • Q96QA2

    Protein attributes for TAGAP Gene

    Size:
    731 amino acids
    Molecular mass:
    80703 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TAGAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAGAP Gene

Post-translational modifications for TAGAP Gene

No Post-translational modifications

Other Protein References for TAGAP Gene

No data available for DME Specific Peptides for TAGAP Gene

Domains & Families for TAGAP Gene

Gene Families for TAGAP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TAGAP Gene

Suggested Antigen Peptide Sequences for TAGAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TAGAP: view

No data available for UniProtKB/Swiss-Prot for TAGAP Gene

Function for TAGAP Gene

Molecular function for TAGAP Gene

UniProtKB/Swiss-Prot Function:
May function as a GTPase-activating protein and may play important roles during T-cell activation.

Phenotypes From GWAS Catalog for TAGAP Gene

Gene Ontology (GO) - Molecular Function for TAGAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with TAGAP: view
genes like me logo Genes that share phenotypes with TAGAP: view

Animal Models for TAGAP Gene

MGI Knock Outs for TAGAP:

miRNA for TAGAP Gene

miRTarBase miRNAs that target TAGAP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAGAP Gene

Localization for TAGAP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAGAP gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TAGAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TAGAP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TAGAP Gene

Pathways & Interactions for TAGAP Gene

genes like me logo Genes that share pathways with TAGAP: view

Pathways by source for TAGAP Gene

Interacting Proteins for TAGAP Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356033%0d%0a9606.ENSP00000267205%0d%0a9606.ENSP00000348461%0d%0a9606.ENSP00000400175%0d%0a9606.ENSP00000304283%0d%0a9606.ENSP00000351132%0d%0a
Selected Interacting proteins: Q8N103-TAGAP_HUMAN ENSP00000356033 for TAGAP Gene via IID STRING

Gene Ontology (GO) - Biological Process for TAGAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with TAGAP: view

No data available for SIGNOR curated interactions for TAGAP Gene

Drugs & Compounds for TAGAP Gene

No Compound Related Data Available

Transcripts for TAGAP Gene

Unigene Clusters for TAGAP Gene

T-cell activation RhoGTPase activating protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAGAP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: -
SP8:
SP9:

Relevant External Links for TAGAP Gene

GeneLoc Exon Structure for
TAGAP
ECgene alternative splicing isoforms for
TAGAP

Expression for TAGAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAGAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAGAP Gene

This gene is overexpressed in Whole Blood (x27.2) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for TAGAP Gene

This gene is overexpressed in Heart (30.8), Peripheral blood mononuclear cells (21.3), Blymphocyte (6.6), and Platelet (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAGAP Gene



Protein tissue co-expression partners for TAGAP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAGAP Gene:

TAGAP

SOURCE GeneReport for Unigene cluster for TAGAP Gene:

Hs.529984

Evidence on tissue expression from TISSUES for TAGAP Gene

  • Lung(4.2)
  • Spleen(4.2)
  • Liver(4.1)
  • Blood(3.8)
genes like me logo Genes that share expression patterns with TAGAP: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAGAP Gene

Orthologs for TAGAP Gene

This gene was present in the common ancestor of animals.

Orthologs for TAGAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAGAP 33 34
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia TAGAP 33 34
  • 79.35 (n)
mouse
(Mus musculus)
Mammalia Tagap 33 16 34
  • 75.94 (n)
Tagap1 34
  • 53 (a)
OneToMany
1700006A11Rik 34
  • 22 (a)
OneToMany
Gm1527 34
  • 15 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tagap 33
  • 75.94 (n)
cow
(Bos Taurus)
Mammalia TAGAP 33 34
  • 73.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TAGAP 34
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAGAP 34
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAGAP 33 34
  • 59.21 (n)
lizard
(Anolis carolinensis)
Reptilia TAGAP 34
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tagap 33
  • 54.29 (n)
zebrafish
(Danio rerio)
Actinopterygii tagapb 33 34
  • 46.09 (n)
tagapa 34
  • 28 (a)
OneToMany
arhgap20 34
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rga-2 34
  • 8 (a)
OneToMany
Species where no ortholog for TAGAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAGAP Gene

ENSEMBL:
Gene Tree for TAGAP (if available)
TreeFam:
Gene Tree for TAGAP (if available)

Paralogs for TAGAP Gene

Paralogs for TAGAP Gene

(1) SIMAP similar genes for TAGAP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAGAP: view

Variants for TAGAP Gene

Sequence variations from dbSNP and Humsavar for TAGAP Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000412339 -- 159,045,152(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000491823 -- 159,040,954(-) C/T intron_variant
rs1000953049 -- 159,041,152(-) A/G intron_variant
rs1000992306 -- 159,046,119(-) G/A upstream_transcript_variant
rs1001366129 -- 159,047,123(-) A/G upstream_transcript_variant

Variation tolerance for TAGAP Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAGAP Gene

Human Gene Mutation Database (HGMD)
TAGAP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAGAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TAGAP Gene

Disorders for TAGAP Gene

MalaCards: The human disease database

(7) MalaCards diseases for TAGAP Gene - From: HGMD, OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, insulin-dependent, 21
  • iddm21
auditory agnosia
anus disease
  • anal disease
autoimmune disease of gastrointestinal tract
multiple sclerosis
  • multiple sclerosis, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search TAGAP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TAGAP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TAGAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAGAP Gene

Publications for TAGAP Gene

  1. Newly identified genetic risk variants for celiac disease related to the immune response. (PMID: 18311140) Hunt KA … van Heel DA (Nature genetics 2008) 2 3 44 58
  2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 44 58
  3. A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease. (PMID: 21298027) Festen EA … Rioux JD (PLoS genetics 2011) 3 44 58
  4. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. (PMID: 22190364) Patsopoulos NA … de Bakker PI (Annals of neurology 2011) 3 44 58
  5. Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort. (PMID: 19693089) Amundsen SS … Sollid LM (Genes and immunity 2010) 3 44 58

Products for TAGAP Gene

Sources for TAGAP Gene

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