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Aliases for ADCYAP1R1 Gene

Aliases for ADCYAP1R1 Gene

  • ADCYAP Receptor Type I 2 3 5
  • Adenylate Cyclase Activating Polypeptide 1 (Pituitary) Receptor Type I 2 3
  • Pituitary Adenylate Cyclase-Activating Polypeptide Type 1 Receptor 2 3
  • PACAP Type I Receptor 3 4
  • PACAP Receptor 1 2 3
  • PACAP-R1 3 4
  • Pituitary Adenylate Cyclase Activating Polypeptide 1 Receptor Type I Hiphop 3
  • Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor 3
  • PACAP-R-1 4
  • PACAPRI 3
  • PACAPR 3
  • PAC1R 3
  • PAC1 3

External Ids for ADCYAP1R1 Gene

Previous GeneCards Identifiers for ADCYAP1R1 Gene

  • GC07P030734
  • GC07P030834
  • GC07P030865

Summaries for ADCYAP1R1 Gene

Entrez Gene Summary for ADCYAP1R1 Gene

  • This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]

GeneCards Summary for ADCYAP1R1 Gene

ADCYAP1R1 (ADCYAP Receptor Type I) is a Protein Coding gene. Diseases associated with ADCYAP1R1 include Type I and Post-Traumatic Stress Disorder. Among its related pathways are Presynaptic function of Kainate receptors and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is VIPR2.

UniProtKB/Swiss-Prot for ADCYAP1R1 Gene

  • This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

Tocris Summary for ADCYAP1R1 Gene

  • Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1 receptors are predominantly expressed in the CNS.

Gene Wiki entry for ADCYAP1R1 Gene

Additional gene information for ADCYAP1R1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCYAP1R1 Gene

Genomics for ADCYAP1R1 Gene

GeneHancer (GH) Regulatory Elements for ADCYAP1R1 Gene

Promoters and enhancers for ADCYAP1R1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J031053 Promoter 0.8 EPDnew 650.7 +0.1 74 0.1 CTCF MXI1 POLR2A PATZ1 ADCYAP1R1 GC07P031106
GH07J031052 Enhancer 0.5 ENCODE 650.7 0.0 -40 0.1 CTCF MXI1 POLR2A GLIS1 PATZ1 EZH2 ADCYAP1R1 LOC105375221
GH07J031026 Enhancer 0.6 ENCODE dbSUPER 19.9 -24.1 -24125 3 POLR2A NRF1 SIN3A ADCYAP1R1 LOC105375221 LOC105375222
GH07J031122 Enhancer 0.7 ENCODE 11.1 +70.4 70441 0.2 CTCF TEAD4 MAX RAD21 FOSL1 SCRT2 ZNF143 SMC3 FOSL2 ZNF444 ADCYAP1R1 ENSG00000232887 PIR43889
GH07J030988 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 6.4 -63.6 -63648 1.1 PKNOX1 ESRRA NEUROD1 KLF17 SIN3A CEBPG BMI1 ZBTB7B RFX5 CTBP1 ADCYAP1R1 LOC105375222 LOC105375221 GHRHR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADCYAP1R1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADCYAP1R1 gene promoter:
  • RP58
  • Nkx2-5
  • FAC1
  • C/EBPalpha
  • HEN1
  • p53
  • FOXL1
  • Zic1
  • LCR-F1
  • Bach2

Genomic Locations for ADCYAP1R1 Gene

Genomic Locations for ADCYAP1R1 Gene
chr7:31,052,341-31,111,479
(GRCh38/hg38)
Size:
59,139 bases
Orientation:
Plus strand
chr7:31,092,076-31,151,093
(GRCh37/hg19)
Size:
59,018 bases
Orientation:
Plus strand

Genomic View for ADCYAP1R1 Gene

Genes around ADCYAP1R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCYAP1R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCYAP1R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCYAP1R1 Gene

Proteins for ADCYAP1R1 Gene

  • Protein details for ADCYAP1R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41586-PACR_HUMAN
    Recommended name:
    Pituitary adenylate cyclase-activating polypeptide type I receptor
    Protein Accession:
    P41586
    Secondary Accessions:
    • A8K1Y1
    • B7ZLA7
    • B8ZZK3
    • Q17S10

    Protein attributes for ADCYAP1R1 Gene

    Size:
    468 amino acids
    Molecular mass:
    53314 Da
    Quaternary structure:
    • Interacts (via N-terminal extracellular domain) with ADCYAP1.
    SequenceCaution:
    • Sequence=BAA04466.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADCYAP1R1 Gene

    Alternative splice isoforms for ADCYAP1R1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADCYAP1R1 Gene

Post-translational modifications for ADCYAP1R1 Gene

  • Glycosylation at Asn375, posLast=300300, posLast=117117, posLast=6060, and Asn48
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADCYAP1R1 Gene

Domains & Families for ADCYAP1R1 Gene

Gene Families for ADCYAP1R1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry

P41586

UniProtKB/Swiss-Prot:

PACR_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with ADCYAP1R1: view

Function for ADCYAP1R1 Gene

Molecular function for ADCYAP1R1 Gene

UniProtKB/Swiss-Prot Function:
This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
GENATLAS Biochemistry:
pituitary adenylyl cyclase activating polypeptide receptor,with five splice variants among which four also activating phospholipase C and a sixth variant (PACAPR-TM4) activating L-type Ca++ channels,expressed in islet beta cells and involved in the physiological control of insulin release

Phenotypes From GWAS Catalog for ADCYAP1R1 Gene

Gene Ontology (GO) - Molecular Function for ADCYAP1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004999 vasoactive intestinal polypeptide receptor activity IEA --
GO:0005515 protein binding IPI 17470806
GO:0008179 adenylate cyclase binding IEA --
genes like me logo Genes that share ontologies with ADCYAP1R1: view
genes like me logo Genes that share phenotypes with ADCYAP1R1: view

Animal Models for ADCYAP1R1 Gene

MGI Knock Outs for ADCYAP1R1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADCYAP1R1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADCYAP1R1 Gene

Localization for ADCYAP1R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCYAP1R1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADCYAP1R1 gene
Compartment Confidence
plasma membrane 5
endosome 3
endoplasmic reticulum 2
extracellular 1
cytoskeleton 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ADCYAP1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005791 rough endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7902709
genes like me logo Genes that share ontologies with ADCYAP1R1: view

Pathways & Interactions for ADCYAP1R1 Gene

genes like me logo Genes that share pathways with ADCYAP1R1: view

SIGNOR curated interactions for ADCYAP1R1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADCYAP1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA,TAS --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007202 activation of phospholipase C activity IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with ADCYAP1R1: view

Drugs & Compounds for ADCYAP1R1 Gene

(20) Drugs for ADCYAP1R1 Gene - From: DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PACAP 1-27 Pharma Potent stimulator of adenylyl cyclase 0
PACAP 1-38 Pharma Potent stimulator of adenylyl cyclase 0
PACAP 6-38 Pharma Potent PAC1 receptor antagonist 0
[<sup>125</sup>I]PACAP-27 Pharma Agonist 0
[Ala<sup>11,22,28</sup>]VIP Pharma Agonist 0

(5) Additional Compounds for ADCYAP1R1 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]VIP
Full agonist, Agonist
[Lys<sup>15</sup>,Arg<sup>16</sup>,Leu<sup>27</sup>]VIP-(1?ao7)/GRF-(8?ao27)-NH<sub>2</sub>
Full agonist, Agonist

(3) Tocris Compounds for ADCYAP1R1 Gene

Compound Action Cas Number
PACAP 1-27 Potent stimulator of adenylyl cyclase 127317-03-7
PACAP 1-38 Potent stimulator of adenylyl cyclase 137061-48-4
PACAP 6-38 Potent PAC1 receptor antagonist 143748-18-9
genes like me logo Genes that share compounds with ADCYAP1R1: view

Transcripts for ADCYAP1R1 Gene

mRNA/cDNA for ADCYAP1R1 Gene

Unigene Clusters for ADCYAP1R1 Gene

Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADCYAP1R1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCYAP1R1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d ^ 17a · 17b ^ 18
SP1: - -
SP2: -
SP3:
SP4: - -
SP5:
SP6: -
SP7: -
SP8:
SP9:

Relevant External Links for ADCYAP1R1 Gene

GeneLoc Exon Structure for
ADCYAP1R1
ECgene alternative splicing isoforms for
ADCYAP1R1

Expression for ADCYAP1R1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADCYAP1R1 Gene

mRNA differential expression in normal tissues according to GTEx for ADCYAP1R1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.9), Brain - Amygdala (x4.9), Brain - Caudate (basal ganglia) (x4.9), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for ADCYAP1R1 Gene

This gene is overexpressed in Frontal cortex (27.6), Serum (26.5), and Spinal cord (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADCYAP1R1 Gene



Protein tissue co-expression partners for ADCYAP1R1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADCYAP1R1 Gene:

ADCYAP1R1

SOURCE GeneReport for Unigene cluster for ADCYAP1R1 Gene:

Hs.377783

mRNA Expression by UniProt/SwissProt for ADCYAP1R1 Gene:

P41586-PACR_HUMAN
Tissue specificity: Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.

Evidence on tissue expression from TISSUES for ADCYAP1R1 Gene

  • Nervous system(4.9)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with ADCYAP1R1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCYAP1R1 Gene

Orthologs for ADCYAP1R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADCYAP1R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCYAP1R1 34 33
  • 99.66 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ADCYAP1R1 34 33
  • 91.47 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADCYAP1R1 34 33
  • 90.39 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adcyap1r1 33
  • 89.19 (n)
mouse
(Mus musculus)
Mammalia Adcyap1r1 16 34 33
  • 88.91 (n)
oppossum
(Monodelphis domestica)
Mammalia ADCYAP1R1 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADCYAP1R1 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADCYAP1R1 34 33
  • 76.81 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCYAP1R1 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adcyap1r1 33
  • 72.19 (n)
African clawed frog
(Xenopus laevis)
Amphibia adcyap1r1-A 33
zebrafish
(Danio rerio)
Actinopterygii ADCYAP1R1 (2 of 2) 34
  • 76 (a)
OneToMany
adcyap1r1a 34 33
  • 74.16 (n)
OneToMany
Species where no ortholog for ADCYAP1R1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADCYAP1R1 Gene

ENSEMBL:
Gene Tree for ADCYAP1R1 (if available)
TreeFam:
Gene Tree for ADCYAP1R1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADCYAP1R1: view image

Paralogs for ADCYAP1R1 Gene

Paralogs for ADCYAP1R1 Gene

(8) SIMAP similar genes for ADCYAP1R1 Gene using alignment to 8 proteins:

  • PACR_HUMAN
  • C9JVH3_HUMAN
  • E9PFU5_HUMAN
  • H0Y813_HUMAN
  • Q6RKA2_HUMAN
  • Q6RKA3_HUMAN
  • Q6S991_HUMAN
  • Q6S992_HUMAN
genes like me logo Genes that share paralogs with ADCYAP1R1: view

Variants for ADCYAP1R1 Gene

Sequence variations from dbSNP and Humsavar for ADCYAP1R1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000026227 -- 31,112,330(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000026979 -- 31,072,725(+) C/A intron_variant
rs1000058285 -- 31,066,656(+) T/C intron_variant
rs1000220339 -- 31,088,724(+) G/T intron_variant
rs1000276665 -- 31,095,366(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADCYAP1R1 Gene

Variant ID Type Subtype PubMed ID
dgv11257n54 CNV loss 21841781
dgv6316n100 CNV gain 25217958
esv2761316 CNV gain 21179565
nsv1023274 CNV gain 25217958
nsv1068321 OTHER inversion 25765185
nsv1128308 CNV deletion 24896259
nsv1148830 OTHER inversion 26484159
nsv436557 CNV deletion 17901297
nsv464418 CNV loss 19166990
nsv519081 CNV loss 19592680
nsv527038 CNV gain 19592680
nsv5685 CNV insertion 18451855

Variation tolerance for ADCYAP1R1 Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADCYAP1R1 Gene

Human Gene Mutation Database (HGMD)
ADCYAP1R1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADCYAP1R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCYAP1R1 Gene

Disorders for ADCYAP1R1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ADCYAP1R1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
type i
post-traumatic stress disorder
  • traumatic neurosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADCYAP1R1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADCYAP1R1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADCYAP1R1 Gene

Publications for ADCYAP1R1 Gene

  1. Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor. (PMID: 7902709) Ogi K … Fujino M (Biochemical and biophysical research communications 1993) 2 3 4 22 58
  2. Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical, and genetic map of chromosome 7. (PMID: 7851900) Stoffel M … Bell GI (Genomics 1994) 3 4 22 58
  3. Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples. (PMID: 21621269) Aragam N … Pan Y (Journal of affective disorders 2011) 3 44 58
  4. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 44 58
  5. Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS. (PMID: 17470806) Sun C … Olejniczak ET (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 4 58

Products for ADCYAP1R1 Gene

Sources for ADCYAP1R1 Gene

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