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Aliases for RBP7 Gene

Aliases for RBP7 Gene

  • Retinol Binding Protein 7 2 3 5
  • Cellular Retinoic Acid-Binding Protein IV 3 4
  • Cellular Retinoic Acid-Binding Protein 4 3 4
  • Retinol Binding Protein 7, Cellular 2 3
  • Cellular Retinol Binding Protein 7 2 3
  • CRABP4 3 4
  • CRBP4 3 4
  • Putative Cellular Retinol-Binding Protein CRBP IV 3
  • Retinoid-Binding Protein 7 3
  • CRABP-IV 4
  • CRBPIV 3

External Ids for RBP7 Gene

Previous GeneCards Identifiers for RBP7 Gene

  • GC01P010018
  • GC01P009767
  • GC01P009991
  • GC01P009979
  • GC01P010057
  • GC01P009212

Summaries for RBP7 Gene

Entrez Gene Summary for RBP7 Gene

  • The protein encoded by this gene is a member of the cellular retinol-binding protein (CRBP) family, whose members are required for vitamin A stability and metabolism. The encoded protein binds all-trans-retinol and is structurally similar to other CRBPs; however, it has a lower binding affinity for retinol than other CRBPs. [provided by RefSeq, Aug 2016]

GeneCards Summary for RBP7 Gene

RBP7 (Retinol Binding Protein 7) is a Protein Coding gene. Diseases associated with RBP7 include Leber Congenital Amaurosis 9 and Leber Congenital Amaurosis. Among its related pathways are Vitamin A and Carotenoid Metabolism and Visual Cycle in Retinal Rods. Gene Ontology (GO) annotations related to this gene include transporter activity and retinol binding. An important paralog of this gene is RBP2.

UniProtKB/Swiss-Prot for RBP7 Gene

  • Intracellular transport of retinol.

Additional gene information for RBP7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBP7 Gene

Genomics for RBP7 Gene

GeneHancer (GH) Regulatory Elements for RBP7 Gene

Promoters and enhancers for RBP7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J009997 Promoter 1.5 EPDnew Ensembl 666.8 +0.4 393 0.8 CTCF KLF1 ZNF777 SUZ12 ZIC2 ZNF335 ZFHX2 GLIS2 POLR2A EZH2 RBP7 UBE4B ENSG00000228150 RN7SKP269 NMNAT1 LZIC CTNNBIP1 RNU6-828P GC01P010029
GH01J009908 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 6.6 -86.4 -86359 4.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B CTNNBIP1 RBP7 GC01M009926
GH01J010471 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 6 +475.4 475357 2.6 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 DFFA PEX14 RBP7
GH01J010031 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 4.9 +36.2 36167 4.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 UBE4B PIR54123 GC01M010031 TARDBP LZIC GPR157 CASZ1 ENSG00000271895 KIF1B RBP7
GH01J010507 Enhancer 1.9 UCNEbase Ensembl ENCODE dbSUPER 5.8 +515.5 515546 11.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 GC01P010513 PGD NMNAT1 PEX14 ENSG00000271989 RBP7 DFFA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RBP7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RBP7 gene promoter:
  • NF-1
  • Pax-5
  • YY1
  • AREB6
  • NCX
  • Elk-1
  • ATF
  • HEN1
  • PPAR-alpha
  • Msx-1

Genomic Locations for RBP7 Gene

Genomic Locations for RBP7 Gene
18,824 bases
Plus strand
18,824 bases
Plus strand

Genomic View for RBP7 Gene

Genes around RBP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBP7 Gene

Proteins for RBP7 Gene

  • Protein details for RBP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinoid-binding protein 7
    Protein Accession:
    Secondary Accessions:
    • B2R517
    • Q5SWJ4

    Protein attributes for RBP7 Gene

    134 amino acids
    Molecular mass:
    15536 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBP7 Gene

neXtProt entry for RBP7 Gene

Post-translational modifications for RBP7 Gene

No Post-translational modifications

Other Protein References for RBP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBP7 Gene

Domains & Families for RBP7 Gene

Gene Families for RBP7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBP7 Gene

Suggested Antigen Peptide Sequences for RBP7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with RBP7: view

Function for RBP7 Gene

Molecular function for RBP7 Gene

UniProtKB/Swiss-Prot Function:
Intracellular transport of retinol.

Phenotypes From GWAS Catalog for RBP7 Gene

Gene Ontology (GO) - Molecular Function for RBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25814554
GO:0008289 lipid binding IEA --
GO:0016918 retinal binding IEA --
GO:0019841 retinol binding IEA --
genes like me logo Genes that share ontologies with RBP7: view
genes like me logo Genes that share phenotypes with RBP7: view

Animal Models for RBP7 Gene

MGI Knock Outs for RBP7:

Animal Model Products

  • Taconic Biosciences Mouse Models for RBP7

CRISPR Products

miRNA for RBP7 Gene

miRTarBase miRNAs that target RBP7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBP7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RBP7 Gene

Localization for RBP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBP7 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBP7 gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nuclear speckles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RBP7: view

Pathways & Interactions for RBP7 Gene

genes like me logo Genes that share pathways with RBP7: view

Pathways by source for RBP7 Gene

1 BioSystems pathway for RBP7 Gene
1 Qiagen pathway for RBP7 Gene

Gene Ontology (GO) - Biological Process for RBP7 Gene


No data available for SIGNOR curated interactions for RBP7 Gene

Drugs & Compounds for RBP7 Gene

(1) Drugs for RBP7 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved, Vet_approved Nutra Carrier 529
genes like me logo Genes that share compounds with RBP7: view

Transcripts for RBP7 Gene

mRNA/cDNA for RBP7 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(39) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RBP7 Gene

Retinol binding protein 7, cellular:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBP7

Alternative Splicing Database (ASD) splice patterns (SP) for RBP7 Gene

No ASD Table

Relevant External Links for RBP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBP7 Gene

mRNA differential expression in normal tissues according to GTEx for RBP7 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x8.0), Adipose - Subcutaneous (x7.1), and Breast - Mammary Tissue (x6.6).

Protein differential expression in normal tissues from HIPED for RBP7 Gene

This gene is overexpressed in Adrenal (42.6) and Nasopharynx (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBP7 Gene

NURSA nuclear receptor signaling pathways regulating expression of RBP7 Gene:


SOURCE GeneReport for Unigene cluster for RBP7 Gene:


mRNA Expression by UniProt/SwissProt for RBP7 Gene:

Tissue specificity: Expressed primarily in kidney, heart and transverse colon. Detected in adult lymph node, appendix, ascending colon, and in fetal heart and spleen.

Evidence on tissue expression from TISSUES for RBP7 Gene

  • Nervous system(4.3)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with RBP7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBP7 Gene

Orthologs for RBP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBP7 34 33
  • 99.75 (n)
(Canis familiaris)
Mammalia RBP7 34 33
  • 90.99 (n)
(Bos Taurus)
Mammalia RBP7 34 33
  • 90.55 (n)
(Mus musculus)
Mammalia Rbp7 16 34 33
  • 87.06 (n)
(Rattus norvegicus)
Mammalia Rbp7 33
  • 85.57 (n)
(Monodelphis domestica)
Mammalia RBP7 34
  • 81 (a)
(Gallus gallus)
Aves RBP7 34 33
  • 75.87 (n)
(Anolis carolinensis)
Reptilia RBP7 34
  • 66 (a)
(Danio rerio)
Actinopterygii rbp7b 34 33
  • 69.9 (n)
rbp7a 34
  • 59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9113 33
Species where no ortholog for RBP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBP7 Gene

Gene Tree for RBP7 (if available)
Gene Tree for RBP7 (if available)
Evolutionary constrained regions (ECRs) for RBP7: view image

Paralogs for RBP7 Gene

Paralogs for RBP7 Gene

genes like me logo Genes that share paralogs with RBP7: view

Variants for RBP7 Gene

Sequence variations from dbSNP and Humsavar for RBP7 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000023223 -- 9,996,037(+) C/T upstream_transcript_variant
rs1000583112 -- 10,006,422(+) A/C intron_variant
rs1000697610 -- 10,006,108(+) C/G intron_variant
rs1000766994 -- 10,012,563(+) G/A intron_variant
rs1000826839 -- 10,002,177(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RBP7 Gene

Variant ID Type Subtype PubMed ID
esv2664618 CNV deletion 23128226
esv2667343 CNV deletion 23128226
esv2671412 CNV deletion 23128226
esv3336969 CNV insertion 20981092
esv3585192 CNV loss 21293372
esv3585193 CNV loss 21293372
esv3585194 CNV loss 21293372
nsv1001742 CNV gain 25217958

Variation tolerance for RBP7 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBP7 Gene

Disorders for RBP7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RBP7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
leber congenital amaurosis 9
  • lca9
leber congenital amaurosis
  • lca
- elite association - COSMIC cancer census association via MalaCards
Search RBP7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RBP7

genes like me logo Genes that share disorders with RBP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBP7 Gene

Publications for RBP7 Gene

  1. Ligand binding and structural analysis of a human putative cellular retinol-binding protein. (PMID: 12177003) Folli C … Berni R (The Journal of biological chemistry 2002) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58

Products for RBP7 Gene

Sources for RBP7 Gene

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