Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FCRL3 Gene

Aliases for FCRL3 Gene

  • Fc Receptor Like 3 2 3 5
  • Immune Receptor Translocation-Associated Protein 3 3 4
  • SH2 Domain-Containing Phosphatase Anchor Protein 2 3 4
  • Fc Receptor Homolog 3 3 4
  • IFGP Family Protein 3 3 4
  • FcR-Like Protein 3 3 4
  • HIFGP3 3 4
  • FCRH3 3 4
  • IFGP3 3 4
  • IRTA3 3 4
  • SPAP2 3 4
  • Immunoglobulin Superfamily Receptor Translocation Associated Protein 3 3
  • Fc Receptor-Like Protein 3 3
  • Fc Receptor-Like 3 2
  • CD307c Antigen 4
  • CD307c 3
  • FcRL3 4

External Ids for FCRL3 Gene

Previous GeneCards Identifiers for FCRL3 Gene

  • GC01M154460
  • GC01M155912
  • GC01M157646
  • GC01M129005

Summaries for FCRL3 Gene

Entrez Gene Summary for FCRL3 Gene

  • This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for FCRL3 Gene

FCRL3 (Fc Receptor Like 3) is a Protein Coding gene. Diseases associated with FCRL3 include Rheumatoid Arthritis and Graves' Disease. Among its related pathways are B Cell Development Pathways. An important paralog of this gene is FCRL5.

UniProtKB/Swiss-Prot for FCRL3 Gene

  • Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275).

Gene Wiki entry for FCRL3 Gene

Additional gene information for FCRL3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRL3 Gene

Genomics for FCRL3 Gene

GeneHancer (GH) Regulatory Elements for FCRL3 Gene

Promoters and enhancers for FCRL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I157695 Promoter/Enhancer 1 EPDnew ENCODE dbSUPER 570.7 +2.1 2051 7.7 POLR2A FCRL3 ENSG00000227217
GH01I157721 Enhancer 1.1 Ensembl ENCODE dbSUPER 24 -23.4 -23449 6.4 NR2F1 ZBTB7B ATF2 RELA GABPA ZNF585B POLR2A IKZF1 NBN ZNF143 VDAC1P9 FCRL3 ENSG00000227217 FCRL2 FCRL1 SONP1
GH01I157773 Enhancer 0.5 ENCODE 18.1 -73.2 -73206 1.5 CTCF TARDBP TRIM22 NBN RAD21 SPI1 PIR43091 FCRL3 FCRL1 FCRL5 FCRL2
GH01I157595 Enhancer 0.8 ENCODE 10.8 +105.4 105449 0.1 EBF1 BMI1 BATF IRF4 POLR2A NFATC1 ATF7 ETV6 BCLAF1 IKZF2 FCRL5 ENSG00000227217 FCRL3 FCRL2 FCRL1 FCRL4
GH01I157652 Enhancer 0.8 Ensembl 9.9 +47.8 47784 0.8 ZFP64 BATF IRF4 BCLAF1 IKZF2 RUNX3 ZBTB11 ZC3H11A JUNB REST RRNAD1 PRCC LOC246784 FCRL3 LRRC71 CD1E MIR765 LOC105371457 ENSG00000233712
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FCRL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FCRL3 gene promoter:

Genomic Locations for FCRL3 Gene

Genomic Locations for FCRL3 Gene
chr1:157,674,321-157,700,985
(GRCh38/hg38)
Size:
26,665 bases
Orientation:
Minus strand
chr1:157,644,111-157,670,647
(GRCh37/hg19)

Genomic View for FCRL3 Gene

Genes around FCRL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCRL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCRL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCRL3 Gene

Proteins for FCRL3 Gene

  • Protein details for FCRL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P31-FCRL3_HUMAN
    Recommended name:
    Fc receptor-like protein 3
    Protein Accession:
    Q96P31
    Secondary Accessions:
    • A0N0M4
    • A8MTH7
    • D3DVD2
    • Q5VXZ8
    • Q8N6S2
    • Q96LA4
    • Q96P27
    • Q96P28
    • Q96P29
    • Q96P30

    Protein attributes for FCRL3 Gene

    Size:
    734 amino acids
    Molecular mass:
    80856 Da
    Quaternary structure:
    • Interacts (via phosphorylated ITIM motifs) with phosphatases INPP5D, PTPN6 and PTPN11. Interacts (via ITIM motifs) SYK and ZAP70.

    Alternative splice isoforms for FCRL3 Gene

neXtProt entry for FCRL3 Gene

Post-translational modifications for FCRL3 Gene

  • Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases.
  • Glycosylation at Asn561
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FCRL3 Gene

Domains & Families for FCRL3 Gene

Gene Families for FCRL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • Predicted membrane proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FCRL3: view

No data available for UniProtKB/Swiss-Prot for FCRL3 Gene

Function for FCRL3 Gene

Molecular function for FCRL3 Gene

UniProtKB/Swiss-Prot Function:
Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275).

Phenotypes From GWAS Catalog for FCRL3 Gene

Gene Ontology (GO) - Molecular Function for FCRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019900 kinase binding IPI 19843936
GO:0019902 phosphatase binding IPI 19843936
genes like me logo Genes that share ontologies with FCRL3: view

Phenotypes for FCRL3 Gene

GenomeRNAi human phenotypes for FCRL3:
genes like me logo Genes that share phenotypes with FCRL3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCRL3 Gene

Localization for FCRL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCRL3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCRL3 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FCRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 16849395
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCRL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCRL3 Gene

Pathways & Interactions for FCRL3 Gene

SuperPathways for FCRL3 Gene

SuperPathway Contained pathways
1 B Cell Development Pathways
genes like me logo Genes that share pathways with FCRL3: view

Pathways by source for FCRL3 Gene

1 R&D Systems pathway for FCRL3 Gene

Gene Ontology (GO) - Biological Process for FCRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002638 negative regulation of immunoglobulin production IDA 23857366
GO:0030890 positive regulation of B cell proliferation IDA 23857366
GO:0034163 regulation of toll-like receptor 9 signaling pathway IDA 23857366
GO:0043410 positive regulation of MAPK cascade IDA 23857366
GO:0045577 regulation of B cell differentiation IDA 23857366
genes like me logo Genes that share ontologies with FCRL3: view

No data available for SIGNOR curated interactions for FCRL3 Gene

Drugs & Compounds for FCRL3 Gene

No Compound Related Data Available

Transcripts for FCRL3 Gene

Unigene Clusters for FCRL3 Gene

Fc receptor-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCRL3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: -
SP3: - - -
SP4:
SP5: -
SP6:
SP7: -
SP8:

Relevant External Links for FCRL3 Gene

GeneLoc Exon Structure for
FCRL3
ECgene alternative splicing isoforms for
FCRL3

Expression for FCRL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCRL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCRL3 Gene

This gene is overexpressed in Spleen (x22.0), Whole Blood (x12.0), and Small Intestine - Terminal Ileum (x10.1).

Protein differential expression in normal tissues from HIPED for FCRL3 Gene

This gene is overexpressed in Plasma (61.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCRL3 Gene



Protein tissue co-expression partners for FCRL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of FCRL3 Gene:

FCRL3

SOURCE GeneReport for Unigene cluster for FCRL3 Gene:

Hs.292449

mRNA Expression by UniProt/SwissProt for FCRL3 Gene:

Q96P31-FCRL3_HUMAN
Tissue specificity: Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Low expression on transitional B cells which increases to higher surface expression on mature and memory B-cells with innate-like features (at protein level) (PubMed:23857366). Expressed a low levels in naive and germinal center B-cells but also expressed in NK cells (at protein level). Expressed in a population of thymically derived natrurally ocurring regulatory T-cells that exhibits a memory phenotype, specialized in suppressing immune response to self-antigens (PubMed:20190142). Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus.

Evidence on tissue expression from TISSUES for FCRL3 Gene

  • Lymph node(4.3)
  • Bone marrow(4)
  • Thyroid gland(2.5)
genes like me logo Genes that share expression patterns with FCRL3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FCRL3 Gene

Orthologs for FCRL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCRL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCRL3 33 34
  • 99.05 (n)
cow
(Bos Taurus)
Mammalia FCRL3 33 34
  • 77.17 (n)
dog
(Canis familiaris)
Mammalia FCRL3 33
  • 76.15 (n)
-- 34
  • 42 (a)
ManyToMany
chicken
(Gallus gallus)
Aves FCRL2 33 34
  • 49.73 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494132 33
  • 46.75 (n)
Species where no ortholog for FCRL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCRL3 Gene

ENSEMBL:
Gene Tree for FCRL3 (if available)
TreeFam:
Gene Tree for FCRL3 (if available)

Paralogs for FCRL3 Gene

genes like me logo Genes that share paralogs with FCRL3: view

Variants for FCRL3 Gene

Sequence variations from dbSNP and Humsavar for FCRL3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_042926 A breast cancer sample p.His445Asn
rs1000151000 -- 157,697,061(-) A/G intron_variant
rs1000297160 -- 157,677,634(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000376176 -- 157,702,396(-) T/C upstream_transcript_variant
rs1000504315 -- 157,683,381(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FCRL3 Gene

Variant ID Type Subtype PubMed ID
esv2761949 CNV loss 21179565
nsv1003791 CNV loss 25217958
nsv520011 CNV loss 19592680
nsv946432 CNV duplication 23825009

Variation tolerance for FCRL3 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCRL3 Gene

Human Gene Mutation Database (HGMD)
FCRL3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCRL3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRL3 Gene

Disorders for FCRL3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for FCRL3 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rheumatoid arthritis
  • ra
graves' disease
  • toxic diffuse goiter
arthritis
  • inflammatory disorder of joint
autoimmune pancreatitis
  • aip
autoimmune disease of endocrine system
- elite association - COSMIC cancer census association via MalaCards
Search FCRL3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FCRL3_HUMAN
  • Note=Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease or multiple sclerosis. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. Multiple sclerosis is an autoimmune/inflammatory neurodegenerative disease which mainly affects young adults and is characterized by destruction of myelin in the central nervous system. {ECO:0000269 PubMed:15838509, ECO:0000269 PubMed:16384851, ECO:0000269 PubMed:17952073, ECO:0000269 PubMed:25862376, ECO:0000269 PubMed:26629249}.
  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269 PubMed:15838509, ECO:0000269 PubMed:16176992, ECO:0000269 PubMed:16476711, ECO:0000269 PubMed:16859508, ECO:0000269 PubMed:17133579, ECO:0000269 PubMed:17179172, ECO:0000269 PubMed:17763442, ECO:0000269 PubMed:22392608, ECO:0000269 PubMed:26746625}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for FCRL3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FCRL3: view

No data available for Genatlas for FCRL3 Gene

Publications for FCRL3 Gene

  1. FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians. (PMID: 17179172) Thabet MM … Huizinga TW (Annals of the rheumatic diseases 2007) 3 4 22 44 58
  2. Supportive evidence for a genetic association of the FCRL3 promoter polymorphism with rheumatoid arthritis. (PMID: 16176992) Ikari K … Kamatani N (Annals of the rheumatic diseases 2006) 3 4 22 44 58
  3. Epistatic interaction between FCRL3 and NFkappaB1 genes in Spanish patients with rheumatoid arthritis. (PMID: 16476711) Martínez A … Martín J (Annals of the rheumatic diseases 2006) 3 4 22 44 58
  4. Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity? (PMID: 16859508) Eyre S … Barton A (Arthritis research & therapy 2006) 3 4 22 44 58
  5. Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population. (PMID: 17133579) Newman WG … Siminovitch KA (Arthritis and rheumatism 2006) 3 4 22 44 58

Products for FCRL3 Gene

Sources for FCRL3 Gene

Content
Loading form....