Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM123 Gene

Aliases for TMEM123 Gene

  • Transmembrane Protein 123 2 3 4 5
  • Pro-Oncosis Receptor Inducing Membrane Injury 3 4
  • KCT-3 3 4
  • KCT3 3 4
  • Pro Oncosis Receptor Inducing Membrane Injury Gene 2
  • Keratinocytes Associated Transmembrane Protein 3 3
  • Keratinocytes-Associated Transmembrane Protein 3 4
  • Serine/Threonine-Rich Receptor 3
  • Porimin 3
  • PORMIN 3

External Ids for TMEM123 Gene

Previous GeneCards Identifiers for TMEM123 Gene

  • GC11M101773
  • GC11M102267
  • GC11M098193

Summaries for TMEM123 Gene

Entrez Gene Summary for TMEM123 Gene

  • This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMEM123 Gene

TMEM123 (Transmembrane Protein 123) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM123 Gene

  • Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.

Gene Wiki entry for TMEM123 Gene

Additional gene information for TMEM123 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM123 Gene

Genomics for TMEM123 Gene

GeneHancer (GH) Regulatory Elements for TMEM123 Gene

Promoters and enhancers for TMEM123 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J102445 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 661.3 +18.8 18828 11.2 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 TMEM123 LOC101928424 BIRC2 MMP7 ENSG00000256916 MMP20 BIRC3 GC11P102396
GH11J102466 Enhancer 1.1 Ensembl ENCODE dbSUPER 650.7 +1.7 1736 3.8 FOXA2 YY1 ZNF335 GATA3 SCRT2 FOSL2 RUNX3 MAFK SCRT1 SMARCE1 TMEM123 LOC102723838
GH11J102429 Enhancer 1.2 Ensembl ENCODE dbSUPER 21.3 +39.7 39736 2.6 HDGF SMAD1 STAT5A FEZF1 BATF IRF4 ZNF143 ATF7 ETV6 BCLAF1 TMEM123 LOC101928424 GC11P102396
GH11J102343 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.1 +123.2 123192 6.5 PKNOX1 SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 BIRC2 TMEM123 BIRC3 GC11P102396
GH11J102493 Enhancer 1.3 Ensembl ENCODE dbSUPER 17.6 -24.4 -24359 2.5 PKNOX1 FOXA2 ARID4B YY1 SLC30A9 ARID2 ZNF143 ATF7 FOS RUNX3 TMEM123 LOC101928424 ENSG00000256916 MMP20 MMP7 BIRC2 LOC102723838
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM123 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM123 gene promoter:
  • POU2F1a
  • POU2F1
  • c-Myb
  • AREB6
  • HNF-3beta
  • E47
  • HSF1short
  • HSF1 (long)
  • Sox5
  • Lmo2

Genomic Locations for TMEM123 Gene

Genomic Locations for TMEM123 Gene
74,060 bases
Minus strand
74,060 bases
Minus strand

Genomic View for TMEM123 Gene

Genes around TMEM123 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM123 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM123 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM123 Gene

Proteins for TMEM123 Gene

  • Protein details for TMEM123 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8IWS2
    • Q96QV2

    Protein attributes for TMEM123 Gene

    208 amino acids
    Molecular mass:
    21531 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM123 Gene


neXtProt entry for TMEM123 Gene

Post-translational modifications for TMEM123 Gene

  • Glycosylation at isoforms=2138, isoforms=2124, posLast=106106, posLast=9696, posLast=8383, isoforms=268, posLast=6464, posLast=5050, and isoforms=46
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM123 Gene

No data available for DME Specific Peptides for TMEM123 Gene

Domains & Families for TMEM123 Gene

Gene Families for TMEM123 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM123 Gene


Suggested Antigen Peptide Sequences for TMEM123 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CD164 family.
  • Belongs to the CD164 family.
genes like me logo Genes that share domains with TMEM123: view

Function for TMEM123 Gene

Molecular function for TMEM123 Gene

UniProtKB/Swiss-Prot Function:
Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.

Phenotypes From GWAS Catalog for TMEM123 Gene

Gene Ontology (GO) - Molecular Function for TMEM123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0038023 signaling receptor activity NAS 9600958
genes like me logo Genes that share ontologies with TMEM123: view
genes like me logo Genes that share phenotypes with TMEM123: view

Animal Models for TMEM123 Gene

MGI Knock Outs for TMEM123:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM123

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM123 Gene

Localization for TMEM123 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM123 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM123 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IDA 9600958
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 11481458
GO:0031410 cytoplasmic vesicle IBA --
genes like me logo Genes that share ontologies with TMEM123: view

Pathways & Interactions for TMEM123 Gene

SuperPathways for TMEM123 Gene

No Data Available

Interacting Proteins for TMEM123 Gene

Gene Ontology (GO) - Biological Process for TMEM123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0070267 oncosis IDA 9600958
genes like me logo Genes that share ontologies with TMEM123: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM123 Gene

Drugs & Compounds for TMEM123 Gene

No Compound Related Data Available

Transcripts for TMEM123 Gene

mRNA/cDNA for TMEM123 Gene

Unigene Clusters for TMEM123 Gene

Transmembrane protein 123:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM123 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - -
SP8: -

Relevant External Links for TMEM123 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM123 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM123 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM123 Gene

This gene is overexpressed in Nasal epithelium (36.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM123 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM123 Gene:


SOURCE GeneReport for Unigene cluster for TMEM123 Gene:


mRNA Expression by UniProt/SwissProt for TMEM123 Gene:

Tissue specificity: Ubiquitous. Not expressed in ovary. Expressed in keratinocytes.

Evidence on tissue expression from TISSUES for TMEM123 Gene

  • Heart(5)
  • Nervous system(4.3)
  • Liver(3.8)
  • Skin(3.5)
  • Lung(3.4)
  • Intestine(2.4)
  • Thyroid gland(2.3)
  • Lymph node(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with TMEM123: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM123 Gene

Orthologs for TMEM123 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM123 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM123 34 33
  • 98.72 (n)
(Mus musculus)
Mammalia Tmem123 16 34 33
  • 68.91 (n)
(Rattus norvegicus)
Mammalia Tmem123 33
  • 68.06 (n)
(Canis familiaris)
Mammalia TMEM123 34
  • 58 (a)
(Monodelphis domestica)
Mammalia TMEM123 34
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM123 34
  • 42 (a)
(Gallus gallus)
Aves TMEM123 34
  • 33 (a)
(Anolis carolinensis)
Reptilia TMEM123 34
  • 27 (a)
Species where no ortholog for TMEM123 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM123 Gene

Gene Tree for TMEM123 (if available)
Gene Tree for TMEM123 (if available)
Evolutionary constrained regions (ECRs) for TMEM123: view image

Paralogs for TMEM123 Gene

No data available for Paralogs for TMEM123 Gene

Variants for TMEM123 Gene

Sequence variations from dbSNP and Humsavar for TMEM123 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000052128 -- 102,452,091(-) A/G intron_variant
rs1000088859 -- 102,414,243(-) GAGGGAG/GAG intron_variant
rs1000089820 -- 102,421,253(-) C/A/G intron_variant
rs1000115052 -- 102,429,358(-) G/A intron_variant
rs1000146586 -- 102,421,442(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM123 Gene

Variant ID Type Subtype PubMed ID
dgv2134n54 CNV loss 21841781
dgv2135n54 CNV loss 21841781
esv22282 CNV loss 19812545
esv2667796 CNV deletion 23128226
esv2677610 CNV deletion 23128226
esv2744989 CNV deletion 23290073
esv2744990 CNV deletion 23290073
esv3548258 CNV deletion 23714750
esv3627526 CNV loss 21293372
esv3627527 CNV loss 21293372
nsv556145 CNV loss 21841781

Variation tolerance for TMEM123 Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM123 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM123 Gene

Disorders for TMEM123 Gene

Additional Disease Information for TMEM123

No disorders were found for TMEM123 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM123 Gene

Publications for TMEM123 Gene

  1. Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death. (PMID: 11481458) Ma F … Schlossman SF (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 22 58
  2. FUT11 as a potential biomarker of clear cell renal cell carcinoma progression based on meta-analysis of gene expression data. (PMID: 24318988) Zodro E … Wesoly J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014) 2 3 58
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TMEM123 Gene

Sources for TMEM123 Gene

Loading form....