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Aliases for PWWP2A Gene

Aliases for PWWP2A Gene

  • PWWP Domain Containing 2A 2 3 5
  • MST101 3 4
  • PWWP Domain-Containing Protein 2A 3
  • KIAA1935 4
  • MSTP101 3

External Ids for PWWP2A Gene

Previous GeneCards Identifiers for PWWP2A Gene

  • GC05M159425
  • GC05M159502
  • GC05M154597

Summaries for PWWP2A Gene

GeneCards Summary for PWWP2A Gene

PWWP2A (PWWP Domain Containing 2A) is a Protein Coding gene. An important paralog of this gene is PWWP2B.

UniProtKB/Swiss-Prot for PWWP2A Gene

  • H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. Also required for proper mitosis progression.

Additional gene information for PWWP2A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PWWP2A Gene

Genomics for PWWP2A Gene

GeneHancer (GH) Regulatory Elements for PWWP2A Gene

Promoters and enhancers for PWWP2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J160118 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 672.1 +1.7 1657 2.3 HDGF PKNOX1 SMAD1 FOXA2 SIN3A FEZF1 ZNF2 ZBTB7B YY1 POLR2B PWWP2A GC05P160046
GH05J160008 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 80.6 +111.3 111289 2.3 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 TTC1 GC05P160010 ENSG00000199398 ZBED8 PWWP2A EBF1 LINC02202 RNF145 C1QTNF2 LINC01845
GH05J159197 Enhancer 1.1 Ensembl ENCODE dbSUPER 30.7 +921.7 921690 2.7 PKNOX1 ZFP64 ZNF140 ZNF223 ZNF266 ZNF697 ATF7 ZNF433 IKZF2 RUNX3 PWWP2A UBLCP1 RNF145 ENSG00000253256 GC05M159165 GC05P159147
GH05J160080 Enhancer 1.1 Ensembl ENCODE 21.9 +39.8 39813 1.4 PKNOX1 FEZF1 TCF12 ZNF143 RUNX3 REST TSHZ1 ZNF592 ATF4 SMARCA4 PWWP2A FABP6 CCNJL ZBED8 GC05P160046
GH05J160369 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 11.9 -249.7 -249749 2 NFXL1 ZNF335 EGR1 EGR2 ZNF263 ZNF362 USF2 ZNF398 RAD51 ZNF341 C1QTNF2 PWWP2A CCNJL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PWWP2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PWWP2A gene promoter:
  • Pax-5
  • E2F-1
  • E2F
  • Pbx1a
  • Zic1
  • Evi-1
  • AML1a
  • Cdc5
  • STAT3

Genomic Locations for PWWP2A Gene

Genomic Locations for PWWP2A Gene
chr5:160,043,562-160,120,808
(GRCh38/hg38)
Size:
77,247 bases
Orientation:
Minus strand
chr5:159,488,808-159,546,452
(GRCh37/hg19)
Size:
57,645 bases
Orientation:
Minus strand

Genomic View for PWWP2A Gene

Genes around PWWP2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PWWP2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PWWP2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PWWP2A Gene

Proteins for PWWP2A Gene

  • Protein details for PWWP2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N64-PWP2A_HUMAN
    Recommended name:
    PWWP domain-containing protein 2A
    Protein Accession:
    Q96N64
    Secondary Accessions:
    • G5EA07
    • Q2HJJ2
    • Q8IYR3
    • Q96PV3

    Protein attributes for PWWP2A Gene

    Size:
    755 amino acids
    Molecular mass:
    81960 Da
    Quaternary structure:
    • Interacts with H2A.Z/H2AFZ.
    SequenceCaution:
    • Sequence=AAH35076.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB67828.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71045.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PWWP2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PWWP2A Gene

Post-translational modifications for PWWP2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for PWWP2A
  • Boster Bio Antibodies for PWWP2A

No data available for DME Specific Peptides for PWWP2A Gene

Domains & Families for PWWP2A Gene

Gene Families for PWWP2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for PWWP2A Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PWWP2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PWWP2A: view

No data available for UniProtKB/Swiss-Prot for PWWP2A Gene

Function for PWWP2A Gene

Molecular function for PWWP2A Gene

UniProtKB/Swiss-Prot Function:
H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. Also required for proper mitosis progression.

Phenotypes From GWAS Catalog for PWWP2A Gene

Gene Ontology (GO) - Molecular Function for PWWP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 28645917
GO:0005515 protein binding IPI 23752268
GO:0042393 histone binding IPI 28645917
genes like me logo Genes that share ontologies with PWWP2A: view
genes like me logo Genes that share phenotypes with PWWP2A: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PWWP2A Gene

Localization for PWWP2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PWWP2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PWWP2A gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Focal adhesion sites (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PWWP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 28645917
genes like me logo Genes that share ontologies with PWWP2A: view

Pathways & Interactions for PWWP2A Gene

SuperPathways for PWWP2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for PWWP2A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PWWP2A Gene

Drugs & Compounds for PWWP2A Gene

No Compound Related Data Available

Transcripts for PWWP2A Gene

Unigene Clusters for PWWP2A Gene

PWWP domain containing 2A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PWWP2A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:
SP2: -
SP3: - -

Relevant External Links for PWWP2A Gene

GeneLoc Exon Structure for
PWWP2A
ECgene alternative splicing isoforms for
PWWP2A

Expression for PWWP2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PWWP2A Gene

Protein differential expression in normal tissues from HIPED for PWWP2A Gene

This gene is overexpressed in Bone marrow stromal cell (23.7), Retina (11.9), Peripheral blood mononuclear cells (9.4), Pancreas (7.8), and Stomach (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PWWP2A Gene



NURSA nuclear receptor signaling pathways regulating expression of PWWP2A Gene:

PWWP2A

SOURCE GeneReport for Unigene cluster for PWWP2A Gene:

Hs.744960

Evidence on tissue expression from TISSUES for PWWP2A Gene

  • Nervous system(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with PWWP2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PWWP2A Gene

Orthologs for PWWP2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for PWWP2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PWWP2A 34 33
  • 99.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PWWP2A 34 33
  • 93.43 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PWWP2A 34 33
  • 88.79 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pwwp2a 16 34 33
  • 88.28 (n)
oppossum
(Monodelphis domestica)
Mammalia PWWP2A 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PWWP2A 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves PWWP2A 34 33
  • 85.53 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PWWP2A 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pwwp2a 33
  • 76.65 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC559090 33
  • 64.02 (n)
PWWP2A 34
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9809 34
  • 25 (a)
OneToMany
Species where no ortholog for PWWP2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PWWP2A Gene

ENSEMBL:
Gene Tree for PWWP2A (if available)
TreeFam:
Gene Tree for PWWP2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PWWP2A: view image

Paralogs for PWWP2A Gene

Paralogs for PWWP2A Gene

(1) SIMAP similar genes for PWWP2A Gene using alignment to 5 proteins:

  • PWP2A_HUMAN
  • G5EA07_HUMAN
  • H0YB44_HUMAN
  • H0YC06_HUMAN
  • H0YC08_HUMAN

Pseudogenes.org Pseudogenes for PWWP2A Gene

genes like me logo Genes that share paralogs with PWWP2A: view

Variants for PWWP2A Gene

Sequence variations from dbSNP and Humsavar for PWWP2A Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1060499752 likely-pathogenic, Abnormality of brain morphology 160,064,970(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000020090 -- 160,104,096(-) C/G intron_variant
rs1000057963 -- 160,095,008(-) A/C intron_variant
rs1000077920 -- 160,066,201(-) C/G/T genic_downstream_transcript_variant, intron_variant
rs1000093511 -- 160,044,196(-) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PWWP2A Gene

Variant ID Type Subtype PubMed ID
dgv1151e214 CNV gain 21293372
esv2671720 CNV deletion 23128226
esv3607363 CNV loss 21293372
esv3607364 CNV gain 21293372
nsv1015634 CNV gain 25217958
nsv1124002 CNV deletion 24896259
nsv830531 CNV loss 17160897

Variation tolerance for PWWP2A Gene

Residual Variation Intolerance Score: 18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PWWP2A Gene

Human Gene Mutation Database (HGMD)
PWWP2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PWWP2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PWWP2A Gene

Disorders for PWWP2A Gene

Additional Disease Information for PWWP2A

No disorders were found for PWWP2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PWWP2A Gene

Publications for PWWP2A Gene

  1. Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation. (PMID: 28645917) Pünzeler S … Hake SB (The EMBO journal 2017) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58

Products for PWWP2A Gene

Sources for PWWP2A Gene

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