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Aliases for ERMAP Gene

Aliases for ERMAP Gene

  • Erythroblast Membrane Associated Protein (Scianna Blood Group) 2 3 5
  • Scianna Blood Group Antigen 3 4
  • Radin Blood Group Antigen 3 4
  • RD 3 4
  • SC 3 4
  • Erythroblast Membrane-Associated Protein (RD And SC Blood Groups) 2
  • Erythroblast Membrane-Associated Protein (Scianna Blood Group) 2
  • Erythroblast Membrane-Associated Protein 2
  • Erythroid Membrane-Associated Protein 3
  • Scianna Blood Group (Sc) 3
  • Radin Blood Group (Rd) 3
  • Scianna Blood Group 2
  • Radin Blood Group 2
  • PRO2801 3
  • HERMAP 4
  • BTN5 3

External Ids for ERMAP Gene

Previous HGNC Symbols for ERMAP Gene

  • RD
  • SC

Previous GeneCards Identifiers for ERMAP Gene

  • GC01P043256
  • GC01P042286
  • GC01P042746
  • GC01P042697
  • GC01P042704
  • GC01P042951
  • GC01P043055
  • GC01P041402

Summaries for ERMAP Gene

Entrez Gene Summary for ERMAP Gene

  • The protein encoded by this gene is a cell surface transmembrane protein that may act as an erythroid cell receptor, possibly as a mediator of cell adhesion. Polymorphisms in this gene are responsible for the Scianna/Radin blood group system. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ERMAP Gene

ERMAP (Erythroblast Membrane Associated Protein (Scianna Blood Group)) is a Protein Coding gene. Diseases associated with ERMAP include Radin Blood Group Antigen. An important paralog of this gene is BTN1A1.

UniProtKB/Swiss-Prot for ERMAP Gene

  • Possible role as a cell-adhesion or receptor molecule of erythroid cells.

Gene Wiki entry for ERMAP Gene

Additional gene information for ERMAP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERMAP Gene

Genomics for ERMAP Gene

GeneHancer (GH) Regulatory Elements for ERMAP Gene

Promoters and enhancers for ERMAP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J042815 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 0.0 -29 2.5 HDGF FOXA2 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B SVBP ERMAP PPIH ENSG00000228192 ZNF691 P3H1 SLC2A1-AS1 GC01M042733 TMEM269
GH01J042824 Promoter/Enhancer 1.7 EPDnew ENCODE dbSUPER 650.4 +8.3 8255 2 HDGF PKNOX1 SMAD1 ATF1 ARNT NCOA2 TCF12 POLR2B ZNF766 GATA2 ERMAP SZT2 P3H1 KDM4A MED8 ZNF691 ENSG00000228192 PPIH C1orf50 SVBP
GH01J042949 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.1 +139.7 139727 15.6 FEZF1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D ZNF585B GLIS1 RCOR2 SLC2A1 SLC2A1-AS1 SZT2 ARTN PPIH P3H1 MED8 RNU6-880P ERMAP LOC101929609
GH01J042845 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.8 +29.9 29869 2.4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 E2F8 ZNF691 ENSG00000228192 SVBP SZT2 FOXJ3 YBX1 CCDC30 PPIH ERMAP PIR46792
GH01J042929 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 3.3 +122.3 122275 19 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 IRF4 ZNF766 SLC2A1-AS1 HYI SZT2 ARTN RNU6-880P FOXJ3 C1orf210 ERMAP CCDC30 YBX1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ERMAP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ERMAP gene promoter:
  • AML1a

Genomic Locations for ERMAP Gene

Genomic Locations for ERMAP Gene
27,906 bases
Plus strand
27,885 bases
Plus strand

Genomic View for ERMAP Gene

Genes around ERMAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERMAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERMAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERMAP Gene

Proteins for ERMAP Gene

  • Protein details for ERMAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Erythroid membrane-associated protein
    Protein Accession:
    Secondary Accessions:
    • D3DPW8
    • Q5VV53
    • Q6DUE0
    • Q7Z3X0
    • Q8NCV8
    • Q8NCW2
    • Q8NCW3
    • Q96PL6

    Protein attributes for ERMAP Gene

    475 amino acids
    Molecular mass:
    52605 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAH72716.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ERMAP Gene

Post-translational modifications for ERMAP Gene

Other Protein References for ERMAP Gene

Antibody Products

  • Boster Bio Antibodies for ERMAP
  • Santa Cruz Biotechnology (SCBT) Antibodies for ERMAP

No data available for DME Specific Peptides for ERMAP Gene

Domains & Families for ERMAP Gene

Gene Families for ERMAP Gene

Human Protein Atlas (HPA):
  • Blood group antigen proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ERMAP Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with ERMAP: view

Function for ERMAP Gene

Molecular function for ERMAP Gene

UniProtKB/Swiss-Prot Function:
Possible role as a cell-adhesion or receptor molecule of erythroid cells.

Phenotypes From GWAS Catalog for ERMAP Gene

Gene Ontology (GO) - Molecular Function for ERMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IBA --
genes like me logo Genes that share ontologies with ERMAP: view

Phenotypes for ERMAP Gene

genes like me logo Genes that share phenotypes with ERMAP: view

Animal Model Products

miRNA for ERMAP Gene

Clone Products

  • Addgene plasmids for ERMAP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERMAP Gene

Localization for ERMAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERMAP Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERMAP gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ERMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IDA 11549310
GO:0009897 external side of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ERMAP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ERMAP Gene

Pathways & Interactions for ERMAP Gene

SuperPathways for ERMAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IBA --
GO:0050776 regulation of immune response IBA --
GO:0050852 T cell receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with ERMAP: view

No data available for Pathways by source and SIGNOR curated interactions for ERMAP Gene

Drugs & Compounds for ERMAP Gene

No Compound Related Data Available

Transcripts for ERMAP Gene

Unigene Clusters for ERMAP Gene

Erythroblast membrane-associated protein (Scianna blood group):
Representative Sequences:

Clone Products

  • Addgene plasmids for ERMAP

Alternative Splicing Database (ASD) splice patterns (SP) for ERMAP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - - -
SP2: -
SP3: - - - - - - - -
SP4: - - - -
SP5: - -

Relevant External Links for ERMAP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ERMAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERMAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ERMAP Gene

This gene is overexpressed in Plasma (46.2), Serum (11.9), and Placenta (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ERMAP Gene

Protein tissue co-expression partners for ERMAP Gene

NURSA nuclear receptor signaling pathways regulating expression of ERMAP Gene:


SOURCE GeneReport for Unigene cluster for ERMAP Gene:


mRNA Expression by UniProt/SwissProt for ERMAP Gene:

Tissue specificity: Expressed in erythroid-enriched bone marrow (at protein level). Highly expressed in bone marrow and to a lower extent in leukocytes, thymus, lymph node and spleen.

Evidence on tissue expression from TISSUES for ERMAP Gene

  • Liver(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ERMAP Gene

Germ Layers:
  • mesoderm
  • immune
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with ERMAP: view

No data available for mRNA differential expression in normal tissues for ERMAP Gene

Orthologs for ERMAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for ERMAP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ERMAP 34 33
  • 99.3 (n)
(Bos Taurus)
Mammalia ERMAP 33
  • 83.67 (n)
(Canis familiaris)
Mammalia ERMAP 34 33
  • 81 (n)
(Mus musculus)
Mammalia Ermap 16 34 33
  • 76.4 (n)
(Rattus norvegicus)
Mammalia Ermap 33
  • 76.38 (n)
(Monodelphis domestica)
Mammalia ERMAP 34
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 18 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14571 33
Species where no ortholog for ERMAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ERMAP Gene

Gene Tree for ERMAP (if available)
Gene Tree for ERMAP (if available)
Evolutionary constrained regions (ECRs) for ERMAP: view image

Paralogs for ERMAP Gene

Paralogs for ERMAP Gene

(13) SIMAP similar genes for ERMAP Gene using alignment to 3 proteins:

  • G4XL73_HUMAN
  • L8EA32_HUMAN Pseudogenes for ERMAP Gene

genes like me logo Genes that share paralogs with ERMAP: view

Variants for ERMAP Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ERMAP Gene

ERMAP is responsible for the Scianna/Radin blood group system which comprises seven different antigens (PubMed:12393480). The Sc1 and Sc2 antigens are resulting from a single variation in position 57; Arg-57 corresponds to the Sc2 antigen and Gly-57 to the Sc1 antigen. The Sc2 antigen is rare with an occurrence of less than 1% in the population while Sc1 is more frequent. Sc3 is not expressed by individuals homozygous for a null allele encoding a truncated protein lacking its extracellular part (Sc-3). The Sc4 antigen corresponding to the previously defined Radin blood group antigen (Rd) is due to a single variation in position 60; Ala-60 corresponds to Sc4/Rd(+), the antigenic form of the protein. Sc4 is found in less than 1% of the population. Sc5/STAR, Sc6/SCER and Sc7/SCAN antigens are due to single variations in positions 47, 81 and 35 respectively. Alloantibodies to the low frequency Sc2 and Sc4 antigens are the cause of hemolytic disease in the newborn (PubMed:15660834, PubMed:16371048).

Sequence variations from dbSNP and Humsavar for ERMAP Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs387906265 pathogenic, SCIANNA BLOOD GROUP SYSTEM, SC:-1,-2 42,830,985(+) GAGAGA/GAGA coding_sequence_variant, frameshift
rs56025238 pathogenic, SCIANNA BLOOD GROUP SYSTEM, SC:-1,2 42,830,851(+) G/A/C coding_sequence_variant, missense_variant
rs56047316 affects, Antigen in Scianna blood group system 42,830,821(+) G/A coding_sequence_variant, missense_variant
rs56136737 affects, Radin blood group 42,830,860(+) C/G/T coding_sequence_variant, missense_variant
rs1000119763 -- 42,817,601(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ERMAP Gene

Variant ID Type Subtype PubMed ID
esv3308455 CNV mobile element insertion 20981092
esv3337682 CNV insertion 20981092
esv3380077 CNV insertion 20981092
esv3577249 CNV gain 25503493
esv3577827 CNV loss 25503493
esv3577829 CNV loss 25503493
esv3585856 CNV loss 21293372
nsv546110 CNV loss 21841781

Variation tolerance for ERMAP Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.74; 66.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ERMAP Gene

Human Gene Mutation Database (HGMD)
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for ERMAP Gene

MalaCards: The human disease database

(1) MalaCards diseases for ERMAP Gene - From: HGMD, OMIM, and GeneCards

Disorder Aliases PubMed IDs
radin blood group antigen
  • rd
- elite association - COSMIC cancer census association via MalaCards
Search ERMAP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ERMAP

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ERMAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ERMAP Gene

Publications for ERMAP Gene

  1. The polymorphism nt 76 in exon 2 of SC is more frequent in whites than in blacks. (PMID: 19856728) Fuchisawa A … Reid ME (Immunohematology 2009) 3 22 44 58
  2. STAR: a novel high-prevalence antigen in the Scianna blood group system. (PMID: 15660834) Hue-Roye K … Reid ME (Transfusion 2005) 3 4 22 58
  3. SCER and SCAN: two novel high-prevalence antigens in the Scianna blood group system. (PMID: 16371048) Flegel WA … Wagner FF (Transfusion 2005) 3 4 22 58
  4. Scianna antigens including Rd are expressed by ERMAP. (PMID: 12393480) Wagner FF … Flegel WA (Blood 2003) 3 4 22 58
  5. Cloning and characterization of human erythroid membrane-associated protein, human ERMAP. (PMID: 11549310) Xu H … Schueler PA (Genomics 2001) 2 3 4 58

Products for ERMAP Gene

Sources for ERMAP Gene

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