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Aliases for RNF13 Gene

Aliases for RNF13 Gene

  • Ring Finger Protein 13 2 3 5
  • RING-Type E3 Ubiquitin Transferase RNF13 3 4
  • RZF 3 4
  • E3 Ubiquitin-Protein Ligase RNF13 3
  • RING Zinc Finger Protein 3
  • RING Finger Protein 13 4
  • EC 4

External Ids for RNF13 Gene

Previous GeneCards Identifiers for RNF13 Gene

  • GC03P146460
  • GC03P150415
  • GC03P150812
  • GC03P150851
  • GC03P151013
  • GC03P149531
  • GC03P146902

Summaries for RNF13 Gene

Entrez Gene Summary for RNF13 Gene

  • The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. The specific function of this gene has not yet been determined. Alternatively spliced transcript variants that encode the same protein have been reported. A pseudogene, which is also located on chromosome 3, has been defined for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF13 Gene

RNF13 (Ring Finger Protein 13) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF167.

UniProtKB/Swiss-Prot for RNF13 Gene

  • E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation.

Gene Wiki entry for RNF13 Gene

Additional gene information for RNF13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF13 Gene

Genomics for RNF13 Gene

GeneHancer (GH) Regulatory Elements for RNF13 Gene

Promoters and enhancers for RNF13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J149811 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 673.5 +2.4 2377 5.9 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 RNF13 PFN2 COMMD2 TSC22D2 ENSG00000242791 RNU6-720P ANKUB1
GH03J149780 Enhancer 0.8 Ensembl ENCODE 12.9 -29.7 -29664 4 USF1 JUN JUNB CEBPB USF2 BATF SP1 JUND GATA3 IKZF1 PFN2 RNF13 WWTR1 WWTR1-AS1 ENSG00000242791 RNU6-507P ANKUB1
GH03J149809 Enhancer 0.5 FANTOM5 19.5 -2.5 -2519 0.3 PRDM6 ATF2 ZNF18 RNF13 RNU6-507P ANKUB1
GH03J149506 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 3.9 -305.1 -305065 2.8 ESRRA FOXA2 JUN MAX EBF1 RARA ETS1 ZNF335 CTBP1 GATA3 COMMD2 WWTR1 TM4SF4 WWTR1-AS1 RNF13 LOC100421817 RNU6-1098P
GH03J149436 Enhancer 0.4 FANTOM5 9.6 -376.1 -376145 0.3 RFX1 ZNF692 TM4SF4 RNF13 RPL32P8 GC03M149445
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF13 gene promoter:
  • LHX3b
  • Lhx3a
  • POU2F1a
  • POU2F1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3

Genomic Locations for RNF13 Gene

Genomic Locations for RNF13 Gene
149,656 bases
Plus strand
149,452 bases
Plus strand

Genomic View for RNF13 Gene

Genes around RNF13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF13 Gene

Proteins for RNF13 Gene

  • Protein details for RNF13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF13
    Protein Accession:
    Secondary Accessions:
    • A6NC87
    • B3KR12
    • Q05D66
    • Q6IBJ9

    Protein attributes for RNF13 Gene

    381 amino acids
    Molecular mass:
    42814 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH17878.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF13 Gene


neXtProt entry for RNF13 Gene

Post-translational modifications for RNF13 Gene

No data available for DME Specific Peptides for RNF13 Gene

Domains & Families for RNF13 Gene

Gene Families for RNF13 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RNF13 Gene

Graphical View of Domain Structure for InterPro Entry



  • The RING-type zinc finger domain is required for E3 ligase activity.
  • The RING-type zinc finger domain is required for E3 ligase activity.
genes like me logo Genes that share domains with RNF13: view

Function for RNF13 Gene

Molecular function for RNF13 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Enzyme Numbers (IUBMB) for RNF13 Gene

Phenotypes From GWAS Catalog for RNF13 Gene

Gene Ontology (GO) - Molecular Function for RNF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0005515 protein binding IPI 19690564
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with RNF13: view
genes like me logo Genes that share phenotypes with RNF13: view

Animal Models for RNF13 Gene

MGI Knock Outs for RNF13:
  • Rnf13 Rnf13<tm1.1(KOMP)Vlcg>

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF13 Gene

Localization for RNF13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF13 Gene

Endoplasmic reticulum membrane. Golgi apparatus membrane. Late endosome membrane; Single-pass membrane protein. Lysosome membrane. Nucleus inner membrane. Note=Under certain conditions, relocalizes to recycling endosomes and to the inner nuclear membrane. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF13 gene
Compartment Confidence
lysosome 5
endosome 5
nucleus 4
cytosol 4
plasma membrane 3
endoplasmic reticulum 3
golgi apparatus 3
extracellular 2
peroxisome 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IEA --
GO:0005637 nuclear inner membrane IEA --
GO:0005654 nucleoplasm IDA --
GO:0005764 lysosome IEA --
genes like me logo Genes that share ontologies with RNF13: view

Pathways & Interactions for RNF13 Gene

SuperPathways for RNF13 Gene

No Data Available

UniProtKB/Swiss-Prot O43567-RNF13_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0051865 protein autoubiquitination ISS --
genes like me logo Genes that share ontologies with RNF13: view

No data available for Pathways by source and SIGNOR curated interactions for RNF13 Gene

Drugs & Compounds for RNF13 Gene

(1) Drugs for RNF13 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RNF13: view

Transcripts for RNF13 Gene

Unigene Clusters for RNF13 Gene

Ring finger protein 13:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF13 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP2: - - -
SP3: - - -

Relevant External Links for RNF13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF13 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.2).

Protein differential expression in normal tissues from HIPED for RNF13 Gene

This gene is overexpressed in Heart (33.5), Peripheral blood mononuclear cells (9.8), Skin (8.3), and Testis (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF13 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF13 Gene:


SOURCE GeneReport for Unigene cluster for RNF13 Gene:


mRNA Expression by UniProt/SwissProt for RNF13 Gene:

Tissue specificity: Widely expressed (at protein level). In normal pancreas, expressed in islets, but not in ducts, nor in acini (at protein level).

Evidence on tissue expression from TISSUES for RNF13 Gene

  • Nervous system(4.9)
  • Muscle(4.3)
  • Spleen(4.3)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with RNF13: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF13 Gene

Orthologs for RNF13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNF13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF13 34 33
  • 100 (n)
(Bos Taurus)
Mammalia RNF13 34 33
  • 95.61 (n)
(Canis familiaris)
Mammalia RNF13 34 33
  • 92.83 (n)
(Monodelphis domestica)
Mammalia RNF13 34
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia RNF13 34
  • 90 (a)
(Mus musculus)
Mammalia Rnf13 16 34 33
  • 89.59 (n)
(Gallus gallus)
Aves RNF13 34 33
  • 80.4 (n)
(Anolis carolinensis)
Reptilia RNF13 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf13 33
  • 70.95 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68556 33
(Danio rerio)
Actinopterygii rnf13 33
  • 68.98 (n)
zgc55660 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002028 33
  • 45.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10277 34 35
  • 23 (a)
(Caenorhabditis elegans)
Secernentea C18B12.4 34
  • 22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RMR1 33
  • 47.84 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.598 34
  • 32 (a)
Cin.7712 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7712 33
Species where no ortholog for RNF13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF13 Gene

Gene Tree for RNF13 (if available)
Gene Tree for RNF13 (if available)
Evolutionary constrained regions (ECRs) for RNF13: view image

Paralogs for RNF13 Gene

(6) SIMAP similar genes for RNF13 Gene using alignment to 15 proteins:

  • B3KR12_HUMAN
  • C9IY58_HUMAN
  • C9J383_HUMAN
  • C9J7B4_HUMAN
  • C9J8T4_HUMAN
  • C9JU37_HUMAN
  • H7C5Q6_HUMAN
  • Q05D66_HUMAN Pseudogenes for RNF13 Gene

genes like me logo Genes that share paralogs with RNF13: view

Variants for RNF13 Gene

Sequence variations from dbSNP and Humsavar for RNF13 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000004986 -- 149,959,154(+) A/G intron_variant
rs1000010526 -- 149,951,807(+) C/A/T intron_variant
rs1000014251 -- 149,955,393(+) G/A/C intron_variant
rs1000030495 -- 149,933,275(+) TTTA/ intron_variant
rs1000031553 -- 149,819,238(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF13 Gene

Variant ID Type Subtype PubMed ID
esv1516102 CNV insertion 17803354
esv2597752 CNV deletion 19546169
esv2664861 CNV deletion 23128226
esv2676965 CNV deletion 23128226
esv3353996 CNV insertion 20981092
esv34142 CNV loss 18971310
esv3562714 CNV deletion 23714750
esv3598149 CNV loss 21293372
esv3598150 CNV loss 21293372
esv3598151 CNV loss 21293372
esv993688 CNV insertion 20482838
nsv1110769 CNV insertion 24896259
nsv1125783 CNV tandem duplication 24896259
nsv965222 CNV duplication 23825009

Variation tolerance for RNF13 Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF13 Gene

Disorders for RNF13 Gene

Additional Disease Information for RNF13

No disorders were found for RNF13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF13 Gene

Publications for RNF13 Gene

  1. Nuclear targeting of an endosomal E3 ubiquitin ligase. (PMID: 20230530) Bocock JP … Erickson AH (Traffic (Copenhagen, Denmark) 2010) 3 22 58
  2. RNF13: a novel RING-type ubiquitin ligase over-expressed in pancreatic cancer. (PMID: 18794910) Zhang Q … Zhu D (Cell research 2009) 3 4 58
  3. Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schröder B … Hasilik A (Traffic (Copenhagen, Denmark) 2007) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RNF13 Gene

Sources for RNF13 Gene

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