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Aliases for DDX19B Gene

Aliases for DDX19B Gene

  • DEAD-Box Helicase 19B 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 19 (Dbp5, Yeast, Homolog) 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 19B 2 3
  • DEAD Box Protein 19B 3 4
  • DDX19 3 4
  • DBP5 3 4
  • DEAD (Asp-Glu-Ala-As) Box Polypeptide 19B 3
  • DEAD (Asp-Glu-Ala-As) Box Polypeptide 19 2
  • ATP-Dependent RNA Helicase DDX19B 3
  • ATP-Dependent RNA Helicase DDX19 3
  • DEAD-Box RNA Helicase DEAD5 3
  • DEAD Box RNA Helicase DEAD5 4
  • DEAD-Box Protein 5 3
  • Yeast Dbp5 Homolog 3
  • EC 3.6.4.13 4
  • RNAh 3
  • TDBP 4

External Ids for DDX19B Gene

Previous HGNC Symbols for DDX19B Gene

  • DDX19

Previous GeneCards Identifiers for DDX19B Gene

  • GC16P068891
  • GC16P070328
  • GC16P056165

Summaries for DDX19B Gene

Entrez Gene Summary for DDX19B Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX19B Gene

DDX19B (DEAD-Box Helicase 19B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is ENSG00000260537.

UniProtKB/Swiss-Prot for DDX19B Gene

  • ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.

Gene Wiki entry for DDX19B Gene

Additional gene information for DDX19B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX19B Gene

Genomics for DDX19B Gene

GeneHancer (GH) Regulatory Elements for DDX19B Gene

Promoters and enhancers for DDX19B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J070287 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 710.6 -0.2 -204 4.1 PKNOX1 SMAD1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B DDX19B AARS PDPR NONOP1 NFAT5 SF3B3 COG4 SMG1P7 LOC400541 COG8
GH16J070298 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.4 +9.7 9681 1.7 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ENSG00000260537 DDX19B COG4 LOC100506083 NPIPB14P PIR35247
GH16J070329 Promoter 0.5 EPDnew 650.3 +39.6 39649 0.1 DDX19B PIR35247 LOC100506083 ENSG00000260537
GH16J069422 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 50.1 -865.0 -865003 3.3 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CYB5B GC16M069468 GC16M069476 DDX19B PDPR NFAT5 NONOP1 CHTF8 ZFP90 LOC400541
GH16J070426 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 36.7 +141.3 141288 8.7 MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 E2F8 SP3 MEF2D PIR61296 NONOP1 DDX19B SF3B3 PDPR NFAT5 COG4 PDXDC2P-NPIPB14P LOC400541 NOB1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DDX19B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DDX19B gene promoter:
  • E2F
  • E2F-1
  • C/EBPbeta
  • GATA-2
  • Elk-1
  • MZF-1
  • Pbx1a
  • CRE-BP1
  • ATF-2
  • NF-Y

Genomic Locations for DDX19B Gene

Genomic Locations for DDX19B Gene
chr16:70,289,663-70,335,283
(GRCh38/hg38)
Size:
45,621 bases
Orientation:
Plus strand
chr16:70,323,566-70,369,186
(GRCh37/hg19)
Size:
45,621 bases
Orientation:
Plus strand

Genomic View for DDX19B Gene

Genes around DDX19B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX19B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX19B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX19B Gene

Proteins for DDX19B Gene

  • Protein details for DDX19B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UMR2-DD19B_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX19B
    Protein Accession:
    Q9UMR2
    Secondary Accessions:
    • B3KNE9
    • B4DXS6
    • E7EMK4
    • Q6FIB7
    • Q6IAE0
    • Q96KE7
    • Q9H0U0

    Protein attributes for DDX19B Gene

    Size:
    479 amino acids
    Molecular mass:
    53927 Da
    Quaternary structure:
    • Interacts with NUP214 or RNA in a mutually exclusive manner.

    Three dimensional structures from OCA and Proteopedia for DDX19B Gene

    Alternative splice isoforms for DDX19B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX19B Gene

Post-translational modifications for DDX19B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DDX19B Gene

Domains & Families for DDX19B Gene

Gene Families for DDX19B Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for DDX19B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UMR2

UniProtKB/Swiss-Prot:

DD19B_HUMAN :
  • The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.
  • Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
Domain:
  • The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.
Family:
  • Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
genes like me logo Genes that share domains with DDX19B: view

Function for DDX19B Gene

Molecular function for DDX19B Gene

UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for DDX19B Gene

Phenotypes From GWAS Catalog for DDX19B Gene

Gene Ontology (GO) - Molecular Function for DDX19B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,TAS --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity TAS 10428971
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with DDX19B: view
genes like me logo Genes that share phenotypes with DDX19B: view

Animal Model Products

CRISPR Products

miRNA for DDX19B Gene

miRTarBase miRNAs that target DDX19B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX19B

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX19B Gene

Localization for DDX19B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX19B Gene

Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Nuclear pore complex cytoplasmic fibrils.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX19B gene
Compartment Confidence
extracellular 5
nucleus 5
mitochondrion 2
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DDX19B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore TAS,IEA --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA,TAS --
GO:0016020 membrane IEA,HDA 19946888
genes like me logo Genes that share ontologies with DDX19B: view

Pathways & Interactions for DDX19B Gene

SuperPathways for DDX19B Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX19B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006406 mRNA export from nucleus TAS 10428971
GO:0008380 RNA splicing IBA --
GO:0010468 regulation of gene expression IBA --
GO:0010501 RNA secondary structure unwinding IBA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with DDX19B: view

No data available for Pathways by source and SIGNOR curated interactions for DDX19B Gene

Drugs & Compounds for DDX19B Gene

(3) Drugs for DDX19B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for DDX19B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DDX19B: view

Transcripts for DDX19B Gene

Unigene Clusters for DDX19B Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DDX19B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX19B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - -
SP2: - -
SP3:

Relevant External Links for DDX19B Gene

GeneLoc Exon Structure for
DDX19B
ECgene alternative splicing isoforms for
DDX19B

Expression for DDX19B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX19B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX19B Gene

This gene is overexpressed in Lymph node (22.5) and Heart (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX19B Gene



Protein tissue co-expression partners for DDX19B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX19B Gene:

DDX19B

SOURCE GeneReport for Unigene cluster for DDX19B Gene:

Hs.221761

Evidence on tissue expression from TISSUES for DDX19B Gene

  • Nervous system(4.6)
  • Stomach(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with DDX19B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX19B Gene

Orthologs for DDX19B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX19B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX19B 34 33
  • 99.72 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 95 (a)
OneToMany
cow
(Bos Taurus)
Mammalia DDX19B 34 33
  • 92.46 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 92 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia DDX19B 33
  • 91.21 (n)
rat
(Rattus norvegicus)
Mammalia Ddx19b 33
  • 90.81 (n)
mouse
(Mus musculus)
Mammalia Ddx19b 16 34 33
  • 90.26 (n)
chicken
(Gallus gallus)
Aves DDX19B 34 33
  • 82.88 (n)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx19b 33
  • 77.92 (n)
MGC75870 33
African clawed frog
(Xenopus laevis)
Amphibia ddx19-prov 33
zebrafish
(Danio rerio)
Actinopterygii ddx19 34 33 33
  • 76.9 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003397 33
  • 63.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dbp80 34 33
  • 60 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ddx-19 34
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP5 34
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8406 34
  • 59 (a)
OneToMany
Cin.4088 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4088 33
Species where no ortholog for DDX19B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX19B Gene

ENSEMBL:
Gene Tree for DDX19B (if available)
TreeFam:
Gene Tree for DDX19B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DDX19B: view image

Paralogs for DDX19B Gene

Paralogs for DDX19B Gene

(19) SIMAP similar genes for DDX19B Gene using alignment to 8 proteins:

  • DD19B_HUMAN
  • H3BMQ5_HUMAN
  • H3BMV7_HUMAN
  • H3BPV3_HUMAN
  • H3BQK0_HUMAN
  • H3BTX1_HUMAN
  • H3BUH0_HUMAN
  • Q2NL95_HUMAN
genes like me logo Genes that share paralogs with DDX19B: view

Variants for DDX19B Gene

Sequence variations from dbSNP and Humsavar for DDX19B Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs779683414 uncertain-significance, Charcot-Marie-Tooth, Type 2 70,289,507(+) A/G upstream_transcript_variant
rs1064794091 likely-benign, not specified 70,289,426(+) /T upstream_transcript_variant
rs879444433 likely-benign, not specified 70,289,429(+) G/A upstream_transcript_variant
rs1000108116 -- 70,328,796(+) G/T intron_variant
rs1000152214 -- 70,320,966(+) /C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DDX19B Gene

Variant ID Type Subtype PubMed ID
esv23255 CNV loss 19812545
esv2714670 CNV deletion 23290073
nsv1061286 CNV gain 25217958
nsv7285 OTHER inversion 18451855
nsv833271 CNV gain+loss 17160897
nsv977994 CNV duplication 23825009

Variation tolerance for DDX19B Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDX19B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX19B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX19B Gene

Disorders for DDX19B Gene

Additional Disease Information for DDX19B

No disorders were found for DDX19B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX19B Gene

Publications for DDX19B Gene

  1. The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner. (PMID: 19219046) von Moeller H … Conti E (Nature structural & molecular biology 2009) 3 4 22 58
  2. Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p. (PMID: 10428971) Schmitt C … Izaurralde E (The EMBO journal 1999) 2 3 4 58
  3. The DEXD/H-box RNA helicase DDX19 is regulated by an {alpha}-helical switch. (PMID: 19244245) Collins R … Schüler H (The Journal of biological chemistry 2009) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for DDX19B Gene

Sources for DDX19B Gene

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