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Aliases for DCTN3 Gene

Aliases for DCTN3 Gene

  • Dynactin Subunit 3 2 3 3 5
  • Dynactin Complex Subunit 22 KDa Subunit 3 4
  • Dynactin 3 (P22) 2 3
  • DCTN22 3 4
  • Dynactin Light Chain 3
  • DCTN-22 3
  • P22 4

External Ids for DCTN3 Gene

Previous GeneCards Identifiers for DCTN3 Gene

  • GC09M034925
  • GC09M034782
  • GC09M034598
  • GC09M034603
  • GC09M034569

Summaries for DCTN3 Gene

Entrez Gene Summary for DCTN3 Gene

  • This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for DCTN3 Gene

DCTN3 (Dynactin Subunit 3) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot for DCTN3 Gene

  • Together with dynein may be involved in spindle assembly and cytokinesis.

Gene Wiki entry for DCTN3 Gene

Additional gene information for DCTN3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTN3 Gene

Genomics for DCTN3 Gene

GeneHancer (GH) Regulatory Elements for DCTN3 Gene

Promoters and enhancers for DCTN3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J034619 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.7 +0.1 137 1.5 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 BRCA1 ZNF48 YY1 ELK1 DCTN3 UBAP2 FAM205A RPP25L C9orf131 ATP8B5P VCP SIGMAR1
GH09J034645 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 -26.8 -26750 2.6 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF213 GALT ENSG00000258728 IL11RA PIGO DCTN3 ENSG00000228352 SIGMAR1
GH09J035525 Enhancer 1.2 Ensembl ENCODE dbSUPER 9.8 -905.9 -905925 2.3 MAX SIN3A CEBPG RAD21 YY1 ZNF664 GATA3 POLR3A FOSL2 MAFK DCTN3 CCDC107 GBA2 RPL36AP33 PIR61372 RUSC2
GH09J034575 Enhancer 0.8 FANTOM5 ENCODE 10.4 +42.3 42295 5.1 ZFHX2 POLR2A ZNF366 ZNF341 REST EZH2 EGR2 GC09P034579 GC09P034580 GALT RPP25L ENSG00000230074 ENHO FAM219A ENSG00000232983 ARID3C CNTFR
GH09J034450 Enhancer 0.7 Ensembl ENCODE 9.8 +169.1 169134 0.9 OSR2 NFE2 BATF IRF4 RUNX3 RPP25L ENHO ENSG00000230729 CNTFR DCTN3 FAM219A DNAI1 C9orf24
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCTN3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCTN3 gene promoter:
  • p53
  • Nkx2-5
  • Nkx5-1
  • Brachyury
  • HOXA9B
  • HOXA9
  • Meis-1
  • Meis-1b
  • HNF-1

Genomic Locations for DCTN3 Gene

Genomic Locations for DCTN3 Gene
6,979 bases
Minus strand
6,968 bases
Minus strand

Genomic View for DCTN3 Gene

Genes around DCTN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCTN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCTN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTN3 Gene

Proteins for DCTN3 Gene

  • Protein details for DCTN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dynactin subunit 3
    Protein Accession:
    Secondary Accessions:
    • A6NII7
    • B2RBM5
    • Q5T1I5
    • Q5T1I7
    • Q5T8G3
    • Q9BPU8

    Protein attributes for DCTN3 Gene

    186 amino acids
    Molecular mass:
    21119 Da
    Quaternary structure:
    • Subunit of dynactin, a multiprotein complex associated with dynein.
    • Sequence=CAI13144.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI14178.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14180.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DCTN3 Gene


neXtProt entry for DCTN3 Gene

Post-translational modifications for DCTN3 Gene

  • Ubiquitination at Lys156 and Lys50
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCTN3 Gene

Domains & Families for DCTN3 Gene

Gene Families for DCTN3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCTN3 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the dynactin subunit 3 family.
  • Belongs to the dynactin subunit 3 family.
genes like me logo Genes that share domains with DCTN3: view

Function for DCTN3 Gene

Molecular function for DCTN3 Gene

UniProtKB/Swiss-Prot Function:
Together with dynein may be involved in spindle assembly and cytokinesis.

Gene Ontology (GO) - Molecular Function for DCTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity TAS 9722614
GO:0005515 protein binding IPI 9722614
genes like me logo Genes that share ontologies with DCTN3: view
genes like me logo Genes that share phenotypes with DCTN3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCTN3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCTN3 Gene

Localization for DCTN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTN3 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCTN3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with DCTN3: view

Pathways & Interactions for DCTN3 Gene

genes like me logo Genes that share pathways with DCTN3: view

Gene Ontology (GO) - Biological Process for DCTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS 9722614
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007017 microtubule-based process IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with DCTN3: view

No data available for SIGNOR curated interactions for DCTN3 Gene

Drugs & Compounds for DCTN3 Gene

No Compound Related Data Available

Transcripts for DCTN3 Gene

Unigene Clusters for DCTN3 Gene

Dynactin 3 (p22):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCTN3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCTN3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - - -
SP9: - - - -
SP11: -

Relevant External Links for DCTN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCTN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCTN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCTN3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.0) and Bone (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCTN3 Gene

Protein tissue co-expression partners for DCTN3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCTN3 Gene:


SOURCE GeneReport for Unigene cluster for DCTN3 Gene:


mRNA Expression by UniProt/SwissProt for DCTN3 Gene:

Tissue specificity: Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain.

Evidence on tissue expression from TISSUES for DCTN3 Gene

  • Nervous system(4.7)
  • Muscle(2.5)
  • Kidney(2)
genes like me logo Genes that share expression patterns with DCTN3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCTN3 Gene

Orthologs for DCTN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCTN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCTN3 34 33
  • 99.64 (n)
(Canis familiaris)
Mammalia DCTN3 34 33
  • 93.01 (n)
(Bos Taurus)
Mammalia DCTN3 34 33
  • 89.96 (n)
(Mus musculus)
Mammalia Dctn3 16 34 33
  • 89.61 (n)
(Rattus norvegicus)
Mammalia Dctn3 33
  • 89.61 (n)
(Monodelphis domestica)
Mammalia DCTN3 34
  • 85 (a)
(Gallus gallus)
Aves DCTN3 34 33
  • 71.04 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25551 33
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1847 33
(Danio rerio)
Actinopterygii dctn3 34 33
  • 59.52 (n)
Dr.28565 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.260 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2692 34
  • 31 (a)
Species where no ortholog for DCTN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCTN3 Gene

Gene Tree for DCTN3 (if available)
Gene Tree for DCTN3 (if available)
Evolutionary constrained regions (ECRs) for DCTN3: view image

Paralogs for DCTN3 Gene

No data available for Paralogs for DCTN3 Gene

Variants for DCTN3 Gene

Sequence variations from dbSNP and Humsavar for DCTN3 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1001062661 -- 34,618,484(-) T/C intron_variant
rs1001760727 -- 34,616,366(-) T/C intron_variant
rs1002036972 -- 34,615,607(-) G/A intron_variant
rs1002330887 -- 34,616,733(-) G/A intron_variant
rs1002741828 -- 34,620,236(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCTN3 Gene

Variant ID Type Subtype PubMed ID
dgv12659n54 CNV loss 21841781
esv3620335 CNV gain 21293372
nsv1125318 OTHER inversion 24896259
nsv1161857 CNV deletion 26073780
nsv818699 CNV gain 17921354
nsv831543 CNV loss 17160897

Variation tolerance for DCTN3 Gene

Residual Variation Intolerance Score: 69.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCTN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTN3 Gene

Disorders for DCTN3 Gene

Additional Disease Information for DCTN3

No disorders were found for DCTN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCTN3 Gene

Publications for DCTN3 Gene

  1. Assignment of p22 dynactin light chain (DCTN3) to human chromosome region 9p13 by radiation hybrid mapping. (PMID: 11306820) Mills DR … Jackson CL (Cytogenetics and cell genetics 2001) 2 3 22 58
  2. Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells. (PMID: 9722614) Karki S … Holzbaur EL (The Journal of cell biology 1998) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for DCTN3 Gene

Sources for DCTN3 Gene

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