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Aliases for RNF24 Gene

Aliases for RNF24 Gene

  • Ring Finger Protein 24 2 3 5
  • RING Finger Protein 24 3
  • G1L 3

External Ids for RNF24 Gene

Previous GeneCards Identifiers for RNF24 Gene

  • GC20M003901
  • GC20M003861
  • GC20M003908
  • GC20M003860
  • GC20M003912
  • GC20M003916

Summaries for RNF24 Gene

Entrez Gene Summary for RNF24 Gene

  • This gene encodes an integral membrane protein that contains a RING-type zinc finger. The encoded protein may interact with multiple transient receptor potential cation channel subfamily C (TRPC) proteins and regulate the trafficking and insertion of these proteins into the plasma membrane. [provided by RefSeq, Mar 2016]

GeneCards Summary for RNF24 Gene

RNF24 (Ring Finger Protein 24) is a Protein Coding gene. An important paralog of this gene is RNF122.

UniProtKB/Swiss-Prot for RNF24 Gene

  • May play a role in TRPCs intracellular trafficking.

Gene Wiki entry for RNF24 Gene

Additional gene information for RNF24 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF24 Gene

Genomics for RNF24 Gene

GeneHancer (GH) Regulatory Elements for RNF24 Gene

Promoters and enhancers for RNF24 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J004012 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 672.2 +1.4 1362 3.9 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A ZNF2 YY1 RNF24 ENSG00000229539 PANK2 ADAM33 AP5S1 SMOX PIR48338
GH20J004062 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.1 -51.6 -51593 9.3 PKNOX1 ZNF121 GLIS2 ZNF143 FOS REST ZNF518A ZNF592 ATF4 ZNF184 RNF24 ENSG00000229539 CENPB C20orf27 AP5S1 ENSG00000205300 RPL21P2
GH20J003929 Enhancer 1 Ensembl ENCODE 19 +85.0 85031 2.7 HDAC1 TCF12 GATA2 PAF1 NCOA1 CEBPB REST ZNF592 NFIC KLF16 PIR37079 PIR55404 ENSG00000229539 RNF24 CENPB PANK2 CDC25B UBOX5-AS1 MAVS GC20P003875
GH20J004037 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -22.7 -22717 1.8 HDGF PKNOX1 ATF1 FEZF1 ZNF2 IRF4 YY1 POLR2B GLIS2 ARID2 ENSG00000236387 PRNT RN7SL555P LOC100421361 ENSG00000229539 RNF24 MAVS PANK2 FTLP3 RPL21P2
GH20J003887 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 8.2 +125.7 125744 4.7 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 ENSG00000229539 PANK2 GC20M003886 UBOX5-AS1 UBOX5 CDC25B ADAM33 RNF24 PRND GC20P003875
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF24 gene promoter:
  • AREB6
  • Egr-2
  • HTF
  • FOXJ2 (long isoform)

Genomic Locations for RNF24 Gene

Genomic Locations for RNF24 Gene
88,274 bases
Minus strand
88,274 bases
Minus strand

Genomic View for RNF24 Gene

Genes around RNF24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF24 Gene

Proteins for RNF24 Gene

  • Protein details for RNF24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 24
    Protein Accession:
    Secondary Accessions:
    • D3DVZ2
    • D3DVZ3
    • Q9UMH1

    Protein attributes for RNF24 Gene

    148 amino acids
    Molecular mass:
    17210 Da
    Quaternary structure:
    • Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7.

    Three dimensional structures from OCA and Proteopedia for RNF24 Gene

    Alternative splice isoforms for RNF24 Gene


neXtProt entry for RNF24 Gene

Post-translational modifications for RNF24 Gene

  • Ubiquitination at Lys107 and Lys61
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF24 Gene

Domains & Families for RNF24 Gene

Gene Families for RNF24 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for RNF24 Gene

Suggested Antigen Peptide Sequences for RNF24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF24: view

No data available for UniProtKB/Swiss-Prot for RNF24 Gene

Function for RNF24 Gene

Molecular function for RNF24 Gene

UniProtKB/Swiss-Prot Function:
May play a role in TRPCs intracellular trafficking.

Phenotypes From GWAS Catalog for RNF24 Gene

Gene Ontology (GO) - Molecular Function for RNF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with RNF24: view
genes like me logo Genes that share phenotypes with RNF24: view

Animal Model Products

miRNA for RNF24 Gene

miRTarBase miRNAs that target RNF24

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF24 Gene

Localization for RNF24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF24 Gene

Golgi apparatus membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF24 gene
Compartment Confidence
golgi apparatus 5
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IDA,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF24: view

Pathways & Interactions for RNF24 Gene

SuperPathways for RNF24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with RNF24: view

No data available for Pathways by source and SIGNOR curated interactions for RNF24 Gene

Drugs & Compounds for RNF24 Gene

No Compound Related Data Available

Transcripts for RNF24 Gene

Unigene Clusters for RNF24 Gene

Ring finger protein 24:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF24 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2: - -
SP3: -

Relevant External Links for RNF24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF24 Gene

This gene is overexpressed in Whole Blood (x13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF24 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF24 Gene:


SOURCE GeneReport for Unigene cluster for RNF24 Gene:


Evidence on tissue expression from TISSUES for RNF24 Gene

  • Kidney(4.1)
  • Blood(4)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with RNF24: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF24 Gene

Orthologs for RNF24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF24 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF24 34 33
  • 99.8 (n)
(Monodelphis domestica)
Mammalia RNF24 34
  • 97 (a)
(Canis familiaris)
Mammalia RNF24 34 33
  • 95.72 (n)
(Bos Taurus)
Mammalia RNF24 34 33
  • 95.27 (n)
(Ornithorhynchus anatinus)
Mammalia RNF24 34
  • 95 (a)
(Mus musculus)
Mammalia Rnf24 16 34 33
  • 92.57 (n)
(Gallus gallus)
Aves RNF24 34 33
  • 83.56 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485988 33
  • 76.83 (n)
Str.3540 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15788 33
(Danio rerio)
Actinopterygii rnf24 34 33
  • 75.9 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
Species where no ortholog for RNF24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF24 Gene

Gene Tree for RNF24 (if available)
Gene Tree for RNF24 (if available)
Evolutionary constrained regions (ECRs) for RNF24: view image

Paralogs for RNF24 Gene

Paralogs for RNF24 Gene

(4) SIMAP similar genes for RNF24 Gene using alignment to 2 proteins:

  • L8E8E3_HUMAN
genes like me logo Genes that share paralogs with RNF24: view

Variants for RNF24 Gene

Sequence variations from dbSNP and Humsavar for RNF24 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000013313 -- 3,997,118(-) C/A/T intron_variant
rs1000026891 -- 3,945,959(-) T/A intron_variant
rs1000072371 -- 3,989,566(-) T/C intron_variant
rs1000083616 -- 4,001,985(-) G/T intron_variant
rs1000102545 -- 3,942,088(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF24 Gene

Variant ID Type Subtype PubMed ID
esv3645053 CNV loss 21293372
esv3645054 CNV gain 21293372
esv3645064 CNV loss 21293372
esv3645065 CNV loss 21293372
nsv1073040 CNV deletion 25765185
nsv1116844 CNV deletion 24896259
nsv1133291 CNV tandem duplication 24896259
nsv472501 CNV novel sequence insertion 20440878
nsv527924 CNV gain 19592680
nsv585308 CNV loss 21841781
nsv828673 CNV gain 20364138

Variation tolerance for RNF24 Gene

Residual Variation Intolerance Score: 50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF24 Gene

Disorders for RNF24 Gene

Additional Disease Information for RNF24

No disorders were found for RNF24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF24 Gene

Publications for RNF24 Gene

  1. RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC. (PMID: 17850865) Lussier MP … Boulay G (Cell calcium 2008) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for RNF24 Gene

Sources for RNF24 Gene

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