Aliases for RNF139 Gene
External Ids for RNF139 Gene
Previous GeneCards Identifiers for RNF139 Gene
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]
GeneCards Summary for RNF139 Gene
RNF139 (Ring Finger Protein 139) is a Protein Coding gene. Diseases associated with RNF139 include Renal Cell Carcinoma, Nonpapillary and Hereditary Renal Cell Carcinoma. Among its related pathways are Calnexin/calreticulin cycle and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is RNF145.
UniProtKB/Swiss-Prot for RNF139 Gene
E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor.