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Aliases for SLC2A6 Gene

Aliases for SLC2A6 Gene

  • Solute Carrier Family 2 Member 6 2 3 5
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 6 2 3
  • Glucose Transporter Type 6 3 4
  • Glucose Transporter Type 9 3 4
  • GLUT-6 3 4
  • GLUT-9 3 4
  • GLUT9 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 6 3
  • HSA011372 3
  • GLUT6 3

External Ids for SLC2A6 Gene

Previous GeneCards Identifiers for SLC2A6 Gene

  • GC09M127425
  • GC09M127893
  • GC09M129689
  • GC09M131612
  • GC09M133366
  • GC09M135326
  • GC09M136336
  • GC09M105837

Summaries for SLC2A6 Gene

Entrez Gene Summary for SLC2A6 Gene

  • Hexose transport into mammalian cells is catalyzed by a family of membrane proteins, including SLC2A6, that contain 12 transmembrane domains and a number of critical conserved residues.[supplied by OMIM, Jul 2002]

GeneCards Summary for SLC2A6 Gene

SLC2A6 (Solute Carrier Family 2 Member 6) is a Protein Coding gene. Diseases associated with SLC2A6 include Testis Seminoma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and HIF1Alpha Pathway. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A8.

UniProtKB/Swiss-Prot for SLC2A6 Gene

  • Facilitative glucose transporter; binds cytochalasin B with low affinity.

Gene Wiki entry for SLC2A6 Gene

Additional gene information for SLC2A6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A6 Gene

Genomics for SLC2A6 Gene

GeneHancer (GH) Regulatory Elements for SLC2A6 Gene

Promoters and enhancers for SLC2A6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I133476 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 557 +0.9 883 3.8 ATF1 ARID4B SIN3A IRF4 ZNF48 GLIS2 ATF7 FOS RUNX3 SP3 SLC2A6 CACFD1 SURF1
GH09I133112 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.4 +350.2 350182 33.8 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 RALGDS GTF3C5 SETX RPL7A GBGT1 BRD3 EEF1A1P5 DDX31 SLC2A6 GTF3C4
GH09I133825 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 21.6 -347.1 -347070 1.8 CEBPB MAFG CEBPG ZIC2 ATF4 POLR2A NFE2 MLLT1 FOS ATF7 SLC2A6 VAV2 DBH RPL7A GC09P133784 GC09M133930
GH09I133821 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 13.1 -343.8 -343844 3.8 HDGF PKNOX1 IRF4 ZNF143 ATF7 ETV6 IKZF2 RUNX3 EGR2 SMARCA5 SLC2A6 VAV2 DBH RPL7A GC09P133784 GC09M133930
GH09I133843 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -366.0 -365969 3.2 STAT1 RXRA MAX ZIC2 RAD21 NR2F2 ZNF23 VEZF1 MLLT1 NFE2 ENSG00000273473 SLC2A6 ENSG00000273249 TSC1 DBH-AS1 RPL7A GC09P133784 GC09M133930 VAV2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC2A6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC2A6 gene promoter:

Genomic Locations for SLC2A6 Gene

Genomic Locations for SLC2A6 Gene
8,061 bases
Minus strand

Genomic View for SLC2A6 Gene

Genes around SLC2A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A6 Gene

Proteins for SLC2A6 Gene

  • Protein details for SLC2A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 6
    Protein Accession:
    Secondary Accessions:
    • A6NNU6
    • Q5SXD7
    • Q8NCC2

    Protein attributes for SLC2A6 Gene

    507 amino acids
    Molecular mass:
    54539 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC2A6 Gene


neXtProt entry for SLC2A6 Gene

Post-translational modifications for SLC2A6 Gene

  • Glycosylation at isoforms=370
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC2A6 Gene

Domains & Families for SLC2A6 Gene

Gene Families for SLC2A6 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLC2A6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A6: view

Function for SLC2A6 Gene

Molecular function for SLC2A6 Gene

UniProtKB/Swiss-Prot Function:
Facilitative glucose transporter; binds cytochalasin B with low affinity.

Phenotypes From GWAS Catalog for SLC2A6 Gene

Gene Ontology (GO) - Molecular Function for SLC2A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity IBA --
GO:0005355 glucose transmembrane transporter activity NAS 10970791
GO:0022857 transmembrane transporter activity IEA --
GO:0055056 D-glucose transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC2A6: view
genes like me logo Genes that share phenotypes with SLC2A6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC2A6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC2A6 Gene

Localization for SLC2A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A6 Gene

Cell membrane; Multi-pass membrane protein. Note=The dileucine internalization motif is critical for intracellular sequestration. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC2A6 gene
Compartment Confidence
plasma membrane 5
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC2A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane NAS,IEA 10970791
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC2A6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC2A6 Gene

Pathways & Interactions for SLC2A6 Gene

genes like me logo Genes that share pathways with SLC2A6: view

Interacting Proteins for SLC2A6 Gene

Gene Ontology (GO) - Biological Process for SLC2A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0008645 hexose transport TAS --
GO:0015992 proton transport IEA --
GO:0035428 hexose transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLC2A6: view

No data available for SIGNOR curated interactions for SLC2A6 Gene

Drugs & Compounds for SLC2A6 Gene

(9) Drugs for SLC2A6 Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
glucose Approved, Vet_approved Pharma Transporter, substrate 0
Fludeoxyglucose F-18 Approved, Investigational Pharma Transporter, substrate 0
Empagliflozin (BI 10773) Pharma SGLT-2 inhibitor for oral treatment of type 2 diabetes 0

(4) Additional Compounds for SLC2A6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for SLC2A6 Gene

Compound Action Cas Number
Empagliflozin (BI 10773) SGLT-2 inhibitor for oral treatment of type 2 diabetes 864070-44-0
genes like me logo Genes that share compounds with SLC2A6: view

Drug Products

Transcripts for SLC2A6 Gene

Unigene Clusters for SLC2A6 Gene

Solute carrier family 2 (facilitated glucose transporter), member 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7: - - - - - -
SP8: - -
SP9: - - - -
SP10: -

Relevant External Links for SLC2A6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC2A6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC2A6 Gene

mRNA differential expression in normal tissues according to GTEx for SLC2A6 Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for SLC2A6 Gene

This gene is overexpressed in Bone (42.0), Peripheral blood mononuclear cells (8.1), Blymphocyte (7.1), and Islet of Langerhans (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC2A6 Gene

Protein tissue co-expression partners for SLC2A6 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC2A6 Gene:


SOURCE GeneReport for Unigene cluster for SLC2A6 Gene:


mRNA Expression by UniProt/SwissProt for SLC2A6 Gene:

Tissue specificity: Highly expressed in brain, spleen and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for SLC2A6 Gene

  • Blood(4.2)
  • Kidney(4.2)
  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with SLC2A6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A6 Gene

Orthologs for SLC2A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC2A6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC2A6 33 34
  • 99.54 (n)
(Canis familiaris)
Mammalia SLC2A6 33 34
  • 87.77 (n)
(Bos Taurus)
Mammalia SLC2A6 33 34
  • 87.31 (n)
(Mus musculus)
Mammalia Slc2a6 33 16 34
  • 82.76 (n)
(Monodelphis domestica)
Mammalia SLC2A6 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia SLC2A6 34
  • 66 (a)
(Gallus gallus)
Aves SLC2A6 33 34
  • 68.77 (n)
(Anolis carolinensis)
Reptilia SLC2A6 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a6 33
  • 61.84 (n)
(Danio rerio)
Actinopterygii slc2a6 33 34
  • 58.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tret1-1 33 34
  • 48.23 (n)
CG8234 35
  • 32 (a)
sut4 35 34
  • 30 (a)
Tret1-2 34
  • 30 (a)
CG1208 35 34
  • 29 (a)
CG1213 35 34
  • 29 (a)
CG6484 35 34
  • 29 (a)
CG15406 35 34
  • 26 (a)
CG8249 35 34
  • 26 (a)
CG10960 34
  • 25 (a)
CG14606 34
  • 25 (a)
CG4797 35 34
  • 24 (a)
CG33281 34
  • 24 (a)
CG14605 34
  • 23 (a)
CG4607 34
  • 23 (a)
CG3285 34
  • 22 (a)
Glut3 34
  • 22 (a)
CG15408 34
  • 21 (a)
CG33282 34
  • 21 (a)
CG8837 34
  • 20 (a)
CG31100 34
  • 18 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta TRET1_ANOGA 33
  • 48.16 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HXT2 34
  • 21 (a)
HXT10 34
  • 20 (a)
HXT14 34
  • 20 (a)
HXT5 34
  • 20 (a)
GAL2 34
  • 19 (a)
HXT1 34
  • 19 (a)
HXT11 34
  • 19 (a)
HXT13 34
  • 19 (a)
HXT3 34
  • 19 (a)
HXT4 34
  • 19 (a)
HXT6 34
  • 19 (a)
HXT7 34
  • 19 (a)
HXT8 34
  • 19 (a)
HXT9 34
  • 19 (a)
STL1 34
  • 19 (a)
HXT15 34
  • 18 (a)
HXT16 34
  • 18 (a)
HXT17 34
  • 18 (a)
RGT2 34
  • 15 (a)
SNF3 34
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
CSA.10291 34
  • 32 (a)
Species where no ortholog for SLC2A6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC2A6 Gene

Gene Tree for SLC2A6 (if available)
Gene Tree for SLC2A6 (if available)

Paralogs for SLC2A6 Gene

Paralogs for SLC2A6 Gene

(1) SIMAP similar genes for SLC2A6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC2A6: view

Variants for SLC2A6 Gene

Sequence variations from dbSNP and Humsavar for SLC2A6 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000030934 -- 133,479,015(-) G/A 5_prime_UTR_variant, coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1000617866 -- 133,475,943(-) C/T intron_variant
rs1000758339 -- 133,476,294(-) G/A 5_prime_UTR_variant, coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1000926789 -- 133,475,921(-) TTTCTTTTCT/TTTCT intron_variant
rs1000959424 -- 133,471,570(-) C/G 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC2A6 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV deletion 23290073
nsv1125319 OTHER inversion 24896259
nsv951799 CNV deletion 24416366

Variation tolerance for SLC2A6 Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC2A6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A6 Gene

Disorders for SLC2A6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC2A6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
testis seminoma
  • seminoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC2A6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC2A6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC2A6 Gene

Publications for SLC2A6 Gene

  1. Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes. (PMID: 10970791) Doege H … Schürmann A (The Biochemical journal 2000) 2 3 4 58
  2. Association between GLUT9 and gout in Japanese men. (PMID: 20413573) Urano W … Yamanaka H (Annals of the rheumatic diseases 2010) 3 44 58
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 44 58
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for SLC2A6 Gene

Sources for SLC2A6 Gene

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