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Aliases for WDR6 Gene

Aliases for WDR6 Gene

  • WD Repeat Domain 6 2 3 5
  • WD Repeat-Containing Protein 6 3

External Ids for WDR6 Gene

Previous GeneCards Identifiers for WDR6 Gene

  • GC15U990073
  • GC03P048192
  • GC03P048899
  • GC03P049003
  • GC03P049019
  • GC03P049044

Summaries for WDR6 Gene

Entrez Gene Summary for WDR6 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

GeneCards Summary for WDR6 Gene

WDR6 (WD Repeat Domain 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include insulin receptor substrate binding.

UniProtKB/Swiss-Prot for WDR6 Gene

  • Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.

Gene Wiki entry for WDR6 Gene

Additional gene information for WDR6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR6 Gene

Genomics for WDR6 Gene

GeneHancer (GH) Regulatory Elements for WDR6 Gene

Promoters and enhancers for WDR6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J049005 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 712.9 +0.3 317 3.1 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 WDR6 ATRIP QRICH1 USP19 CCDC36 ENSG00000225399 PRKAR2A IMPDH2 ENSG00000235236 ARIH2
GH03J049016 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 71 +13.2 13199 6.8 CLOCK ZFP64 FEZF1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC ZFP41 DALRD3 NDUFAF3 MIR425 MIR191 GC03M049024 WDR6 ENSG00000235236 NICN1 FCF1P2 QRICH1
GH03J048917 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 61.8 -88.2 -88244 3.4 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B ARIH2OS ARIH2 WDR6 QRICH1 CCDC71 IP6K2 ZNF589 AMT SLC25A20
GH03J049118 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 52.6 +113.5 113452 3.3 SMAD1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B E2F8 ZNF207 ZNF143 USP19 WDR6 LAMB2 QARS
GH03J049027 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 51.7 +21.9 21869 3.4 PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 ENSG00000272434 IMPDH2 WDR6 ATRIP QRICH1 NME6 USP19 MRPS18AP1 TMEM89 RBM6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR6 gene promoter:
  • CUTL1
  • Pax-6
  • AREB6
  • SRF
  • C/EBPbeta
  • ARP-1
  • SRF (504 AA)
  • SEF-1 (1)
  • Olf-1
  • Lmo2

Genomic Locations for WDR6 Gene

Genomic Locations for WDR6 Gene
8,892 bases
Plus strand
8,892 bases
Plus strand

Genomic View for WDR6 Gene

Genes around WDR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR6 Gene

Proteins for WDR6 Gene

  • Protein details for WDR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • B4DHK2
    • Q3MIT1
    • Q9UF63

    Protein attributes for WDR6 Gene

    1121 amino acids
    Molecular mass:
    121725 Da
    Quaternary structure:
    • Interacts with IRS4 (By similarity). Interacts with STK11/LKB1.
    • Sequence=BAG58164.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for WDR6 Gene

Post-translational modifications for WDR6 Gene

  • Ubiquitination at posLast=915915, isoforms=910, isoforms=855, posLast=708708, posLast=526526, isoforms=490, isoforms=437, posLast=418418, isoforms=343, and posLast=237237
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WDR6 Gene

Domains & Families for WDR6 Gene

Gene Families for WDR6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat WDR6 family.
  • Belongs to the WD repeat WDR6 family.
genes like me logo Genes that share domains with WDR6: view

Function for WDR6 Gene

Molecular function for WDR6 Gene

UniProtKB/Swiss-Prot Function:
Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.

Phenotypes From GWAS Catalog for WDR6 Gene

Gene Ontology (GO) - Molecular Function for WDR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI,IEA 17216128
GO:0043560 insulin receptor substrate binding IEA --
genes like me logo Genes that share ontologies with WDR6: view
genes like me logo Genes that share phenotypes with WDR6: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR6 Gene

Localization for WDR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR6 Gene

Cytoplasm. Note=Colocalizes in the cytoplasm with STK11/LKB1.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR6 gene
Compartment Confidence
plasma membrane 5
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 17216128
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0008180 colocalizes_with COP9 signalosome IDA 18850735
genes like me logo Genes that share ontologies with WDR6: view

Pathways & Interactions for WDR6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest IDA 17216128
GO:0008285 negative regulation of cell proliferation IDA 17216128
GO:0010507 negative regulation of autophagy IMP 22354037
genes like me logo Genes that share ontologies with WDR6: view

No data available for Pathways by source and SIGNOR curated interactions for WDR6 Gene

Drugs & Compounds for WDR6 Gene

No Compound Related Data Available

Transcripts for WDR6 Gene

mRNA/cDNA for WDR6 Gene

Unigene Clusters for WDR6 Gene

WD repeat domain 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: - -
SP8: - - -

Relevant External Links for WDR6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR6 Gene

This gene is overexpressed in Plasma (33.5), Lung (6.6), Skin (6.4), and Heart (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDR6 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR6 Gene:


SOURCE GeneReport for Unigene cluster for WDR6 Gene:


mRNA Expression by UniProt/SwissProt for WDR6 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for WDR6 Gene

  • Nervous system(5)
  • Heart(4.3)
  • Lung(3.1)
  • Intestine(2.4)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with WDR6: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR6 Gene

Orthologs for WDR6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR6 34 33
  • 98.74 (n)
(Canis familiaris)
Mammalia WDR6 34 33
  • 89.13 (n)
(Bos Taurus)
Mammalia WDR6 34 33
  • 86.82 (n)
(Rattus norvegicus)
Mammalia Wdr6 33
  • 85.34 (n)
(Mus musculus)
Mammalia Wdr6 16 34 33
  • 84.15 (n)
(Monodelphis domestica)
Mammalia WDR6 34
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia WDR6 34
  • 48 (a)
(Gallus gallus)
Aves WDR6 34 33
  • 56.62 (n)
(Anolis carolinensis)
Reptilia WDR6 34
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr6 33
  • 52.5 (n)
(Danio rerio)
Actinopterygii wdr6 34 33
  • 48.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG33172 34 33
  • 41.92 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004545 33
  • 41.21 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL056C 33
  • 42.43 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTT10 34 33
  • 38.67 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18899g 33
  • 37.29 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07492 33
  • 41.1 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1306.02 33
  • 38.76 (n)
Species where no ortholog for WDR6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR6 Gene

Gene Tree for WDR6 (if available)
Gene Tree for WDR6 (if available)
Evolutionary constrained regions (ECRs) for WDR6: view image

Paralogs for WDR6 Gene

(36) SIMAP similar genes for WDR6 Gene using alignment to 13 proteins:

  • C9K020_HUMAN
  • F8WE36_HUMAN
  • V9GZ48_HUMAN
  • V9GZ65_HUMAN
genes like me logo Genes that share paralogs with WDR6: view

No data available for Paralogs for WDR6 Gene

Variants for WDR6 Gene

Sequence variations from dbSNP and Humsavar for WDR6 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs483352745 uncertain-significance, not provided 49,013,491(+) T/G coding_sequence_variant, missense_variant
rs1000378201 -- 49,009,463(+) G/A intron_variant
rs1000433245 -- 49,009,949(+) A/G intron_variant
rs1000550060 -- 49,015,348(+) G/C 3_prime_UTR_variant
rs1000995727 -- 49,007,979(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR6 Gene

Variant ID Type Subtype PubMed ID
nsv954488 CNV deletion 24416366

Variation tolerance for WDR6 Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.94; 49.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR6 Gene

Disorders for WDR6 Gene

Additional Disease Information for WDR6

No disorders were found for WDR6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR6 Gene

Publications for WDR6 Gene

  1. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PMID: 22354037) McKnight NC … Tooze SA (The EMBO journal 2012) 3 4 58
  2. Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction. (PMID: 17216128) Xie X … Chen Y (Molecular and cellular biochemistry 2007) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene. (PMID: 10903905) Li D … Roberts R (Biochemical and biophysical research communications 2000) 3 4 58

Products for WDR6 Gene

Sources for WDR6 Gene

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