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Aliases for ZNF277 Gene

Aliases for ZNF277 Gene

  • Zinc Finger Protein 277 2 3 3 5
  • Nuclear Receptor-Interacting Factor 4 3 4
  • Zinc Finger Protein (C2H2 Type) 277 2 3
  • Zinc Finger Protein 277 Pseudogene 2 3
  • ZNF277P 3 4
  • NRIF4 3 4

External Ids for ZNF277 Gene

Previous HGNC Symbols for ZNF277 Gene

  • ZNF277P

Previous GeneCards Identifiers for ZNF277 Gene

  • GC07P110330
  • GC07P111393
  • GC07P111407
  • GC07P111440
  • GC07P111633
  • GC07P111846
  • GC07P106214

Summaries for ZNF277 Gene

GeneCards Summary for ZNF277 Gene

ZNF277 (Zinc Finger Protein 277) is a Protein Coding gene. Diseases associated with ZNF277 include Specific Language Impairment and Speech And Communication Disorders. Gene Ontology (GO) annotations related to this gene include RNA polymerase II core promoter sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ZNF277 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF277 Gene

Additional gene information for ZNF277 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF277 Gene

Genomics for ZNF277 Gene

GeneHancer (GH) Regulatory Elements for ZNF277 Gene

Promoters and enhancers for ZNF277 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J112202 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 -1.5 -1458 5.8 HDGF SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF143 DOCK4 ZNF277 GC07M112184
GH07J112079 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 6.8 -125.5 -125463 3 FOXA2 SIN3A BATF IRF4 RAD21 RFX5 ZNF143 RCOR1 ATF7 FOS DOCK4 IFRD1 ZNF277 GC07M112041 GC07M112180
GH07J112103 Enhancer 0.6 FANTOM5 15.5 -103.3 -103263 0.5 OSR2 FOXA2 FOXA3 NFKBIZ DOCK4 ZNF277 IFRD1 GC07M112041 GC07M112180
GH07J111986 Enhancer 0.9 FANTOM5 Ensembl ENCODE 7.7 -219.2 -219204 1.6 JUND JUN CEBPB DOCK4 ZNF277 IFRD1 RPL7AP42 GC07P112024
GH07J112083 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 4.9 -122.0 -121987 1.6 USF1 RELA YY1 NFE2 ETV6 IKZF2 RUNX3 NFE2L2 GFI1B DPF2 DOCK4 ZNF277 IFRD1 GC07M112041 GC07M112180
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF277 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF277 gene promoter:
  • Chx10
  • TGIF
  • CREB
  • STAT5B
  • Pax-4a
  • Olf-1
  • AREB6
  • Egr-4
  • Evi-1
  • IRF-1

Genomic Locations for ZNF277 Gene

Genomic Locations for ZNF277 Gene
137,347 bases
Plus strand
137,347 bases
Plus strand

Genomic View for ZNF277 Gene

Genes around ZNF277 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF277 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF277 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF277 Gene

Proteins for ZNF277 Gene

  • Protein details for ZNF277 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 277
    Protein Accession:
    Secondary Accessions:
    • Q75MZ2
    • Q75MZ3
    • Q8WY14

    Protein attributes for ZNF277 Gene

    450 amino acids
    Molecular mass:
    52788 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF85941.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAS07413.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF277 Gene

Post-translational modifications for ZNF277 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF277 Gene

Domains & Families for ZNF277 Gene

Gene Families for ZNF277 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF277 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZNF277 family.
  • Belongs to the ZNF277 family.
genes like me logo Genes that share domains with ZNF277: view

Function for ZNF277 Gene

Molecular function for ZNF277 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF277 Gene

Gene Ontology (GO) - Molecular Function for ZNF277 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IBA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZNF277: view
genes like me logo Genes that share phenotypes with ZNF277: view

Animal Models for ZNF277 Gene

MGI Knock Outs for ZNF277:

Animal Model Products

miRNA for ZNF277 Gene

miRTarBase miRNAs that target ZNF277

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF277 Gene

Localization for ZNF277 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF277 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF277 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF277 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF277: view

Pathways & Interactions for ZNF277 Gene

SuperPathways for ZNF277 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF277 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0070301 cellular response to hydrogen peroxide IEA --
GO:2000772 regulation of cellular senescence IEA --
genes like me logo Genes that share ontologies with ZNF277: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF277 Gene

Drugs & Compounds for ZNF277 Gene

No Compound Related Data Available

Transcripts for ZNF277 Gene

mRNA/cDNA for ZNF277 Gene

Unigene Clusters for ZNF277 Gene

Zinc finger protein 277:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF277 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2: -
SP3: -
SP4: - - -
SP5: - - - - -

Relevant External Links for ZNF277 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF277 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF277 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF277 Gene

This gene is overexpressed in Monocytes (42.5), Lung (14.4), and CD4 Tcells (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF277 Gene

Protein tissue co-expression partners for ZNF277 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF277 Gene:


SOURCE GeneReport for Unigene cluster for ZNF277 Gene:


Evidence on tissue expression from TISSUES for ZNF277 Gene

  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with ZNF277: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF277 Gene

Orthologs for ZNF277 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF277 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF277 34 33
  • 99.56 (n)
(Canis familiaris)
Mammalia ZNF277 34 33
  • 92.07 (n)
(Bos Taurus)
Mammalia ZNF277 34 33
  • 91.24 (n)
(Rattus norvegicus)
Mammalia Zfp277 33
  • 85.04 (n)
(Mus musculus)
Mammalia Zfp277 16 34 33
  • 84.37 (n)
(Monodelphis domestica)
Mammalia ZNF277 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 80 (a)
-- 34
  • 67 (a)
(Gallus gallus)
Aves ZNF277 34 33
  • 75.31 (n)
(Anolis carolinensis)
Reptilia ZNF277 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf277 33
  • 70.8 (n)
Str.9892 33
(Danio rerio)
Actinopterygii znf277 34 33
  • 63.94 (n)
zgc66407 33
fruit fly
(Drosophila melanogaster)
Insecta CG9890 34 35 33
  • 47.52 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011876 33
  • 47.04 (n)
(Caenorhabditis elegans)
Secernentea ztf-7 34 33
  • 50.7 (n)
F46B6.7 35
  • 37 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC19B12.07c 33
  • 48.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
-- 34
  • 39 (a)
Cin.7832 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7832 33
Species where no ortholog for ZNF277 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF277 Gene

Gene Tree for ZNF277 (if available)
Gene Tree for ZNF277 (if available)
Evolutionary constrained regions (ECRs) for ZNF277: view image

Paralogs for ZNF277 Gene

(1) SIMAP similar genes for ZNF277 Gene using alignment to 10 proteins:

  • ZN277_HUMAN
  • A4D0S7_HUMAN
  • C9J3B6_HUMAN
  • C9JH62_HUMAN
  • E7EW13_HUMAN
  • G5E9M4_HUMAN
  • H7C460_HUMAN
  • Q75MZ1_HUMAN
genes like me logo Genes that share paralogs with ZNF277: view

No data available for Paralogs for ZNF277 Gene

Variants for ZNF277 Gene

Sequence variations from dbSNP and Humsavar for ZNF277 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
VAR_035574 A breast cancer sample p.Ile332Leu
VAR_035575 A breast cancer sample p.Leu445Phe
rs1000009722 -- 112,306,781(+) T/A intron_variant
rs1000059072 -- 112,212,796(+) T/G intron_variant
rs1000085830 -- 112,205,558(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF277 Gene

Variant ID Type Subtype PubMed ID
dgv1322e214 CNV loss 21293372
dgv1948e212 CNV loss 25503493
dgv1949e212 CNV loss 25503493
esv2422365 CNV duplication 17116639
esv2656841 CNV deletion 23128226
esv2762697 CNV loss 21179565
esv2764032 CNV loss 21179565
esv3303795 CNV mobile element insertion 20981092
esv3439705 CNV insertion 20981092
esv3542285 CNV deletion 23714750
esv3572069 CNV loss 25503493
esv3614619 CNV loss 21293372
esv3614620 CNV loss 21293372
esv3891191 CNV loss 25118596
nsv1020212 CNV gain 25217958
nsv464689 CNV gain 19166990
nsv5902 CNV deletion 18451855
nsv608200 CNV gain 21841781
nsv608226 CNV gain 21841781

Variation tolerance for ZNF277 Gene

Residual Variation Intolerance Score: 29.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF277 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF277 Gene

Disorders for ZNF277 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF277 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
specific language impairment
speech and communication disorders
  • communication disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF277

genes like me logo Genes that share disorders with ZNF277: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF277 Gene

Publications for ZNF277 Gene

  1. Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277. (PMID: 10860669) Liang H … Nagarajan L (Genomics 2000) 2 3 4 58
  2. Human-specific nonsense mutations identified by genome sequence comparisons. (PMID: 16395595) Hahn Y … Lee B (Human genetics 2006) 2 3 58
  3. Finer delineation and transcript map of the 7q31 locus deleted in myeloid neoplasms. (PMID: 16213364) Liang H … Nagarajan L (Cancer genetics and cytogenetics 2005) 2 3 58
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF277 Gene

Sources for ZNF277 Gene

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