Aliases for WDHD1 Gene
External Ids for WDHD1 Gene
Previous GeneCards Identifiers for WDHD1 Gene
The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for WDHD1 Gene
WDHD1 (WD Repeat And HMG-Box DNA Binding Protein 1) is a Protein Coding gene. Diseases associated with WDHD1 include Trench Fever. Among its related pathways are Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include RNA binding and RNA polymerase binding.
UniProtKB/Swiss-Prot for WDHD1 Gene
Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.