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Aliases for NUDT6 Gene

Aliases for NUDT6 Gene

  • Nudix Hydrolase 6 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 6 2 3
  • Antisense Basic Fibroblast Growth Factor 3 4
  • FGF2AS 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 6 3
  • Nudix Motif 6 4
  • Protein GFG 4
  • EC 3.6.1.- 4
  • ASFGF2 3
  • FGF-AS 3
  • GFG-1 3
  • GFG1 3

External Ids for NUDT6 Gene

Previous GeneCards Identifiers for NUDT6 Gene

  • GC04M124726
  • GC04M124093
  • GC04M124207
  • GC04M124272
  • GC04M124171
  • GC04M123814
  • GC04M119540

Summaries for NUDT6 Gene

Entrez Gene Summary for NUDT6 Gene

  • This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NUDT6 Gene

NUDT6 (Nudix Hydrolase 6) is a Protein Coding gene. Diseases associated with NUDT6 include Epilepsy, Hearing Loss, And Mental Retardation Syndrome and Prostatic Adenoma. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include hydrolase activity and growth factor activity.

UniProtKB/Swiss-Prot for NUDT6 Gene

  • May contribute to the regulation of cell proliferation.

Gene Wiki entry for NUDT6 Gene

Additional gene information for NUDT6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT6 Gene

Genomics for NUDT6 Gene

GeneHancer (GH) Regulatory Elements for NUDT6 Gene

Promoters and enhancers for NUDT6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J122920 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 662.6 +0.3 347 3.8 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF143 SP3 SP5 NUDT6 SPATA5 ENSG00000237868 FGF2 ENSG00000273007
GH04J122897 Enhancer 1 Ensembl ENCODE dbSUPER 22 +24.3 24252 2.9 ZNF362 JUN USF2 CEBPB REST EP300 RFX5 MITF SP1 SREBF1 NUDT6 FGF2 SPATA5 ENSG00000273007
GH04J122763 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +158.2 158199 4 PKNOX1 FOXA2 ARNT DMAP1 IRF4 GTF3C2 TCF12 FOS ATF7 RUNX3 SPATA5 CETN4P FGF2 ENSG00000237868 BBS12 EXOSC9 NUDT6 CCNA2 LOC727709 RPL34P12
GH04J122795 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +124.9 124852 4.5 HDAC1 PKNOX1 TAF9B ZBTB40 ZNF766 ZNF366 ATF7 RXRA CEBPB USF2 FGF2 NUDT6 SPATA5 IL21-AS1 CETN4P SPRY1 RPL34P12 LOC727709
GH04J122781 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +139.3 139269 4.2 FOXA2 SIN3A RFX5 YY1 ZNF143 RCOR1 FOS RUNX3 RXRA CEBPB FGF2 SPATA5 NUDT6 CETN4P SPRY1 RPL34P12 LOC727709
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUDT6 gene promoter:
  • STAT3
  • AP-1
  • ATF

Genomic Locations for NUDT6 Gene

Genomic Locations for NUDT6 Gene
34,308 bases
Minus strand
34,272 bases
Minus strand

Genomic View for NUDT6 Gene

Genes around NUDT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT6 Gene

Proteins for NUDT6 Gene

  • Protein details for NUDT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 6
    Protein Accession:
    Secondary Accessions:
    • A8K756
    • O95097
    • Q9UQD9

    Protein attributes for NUDT6 Gene

    316 amino acids
    Molecular mass:
    35679 Da
    Quaternary structure:
    • Monomer and homodimer.
    • This protein is coded from a FGF2 (BFGF) gene antisense transcript.

    Three dimensional structures from OCA and Proteopedia for NUDT6 Gene

    Alternative splice isoforms for NUDT6 Gene


neXtProt entry for NUDT6 Gene

Post-translational modifications for NUDT6 Gene

  • Ubiquitination at Lys76
  • Modification sites at PhosphoSitePlus

Other Protein References for NUDT6 Gene

No data available for DME Specific Peptides for NUDT6 Gene

Domains & Families for NUDT6 Gene

Gene Families for NUDT6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NUDT6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Nudix hydrolase family.
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT6: view

Function for NUDT6 Gene

Molecular function for NUDT6 Gene

UniProtKB/Swiss-Prot Function:
May contribute to the regulation of cell proliferation.
GENATLAS Biochemistry:
nudix (nucleoside diphosphate linked moiety X)-type motif 6,hydrolase,antisense transcript of FGF2,coexpressed with FGF2 in many tissues,and potentially regulator of FGF2 expression,putative mouse cleaning gene whose functions is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways

Enzyme Numbers (IUBMB) for NUDT6 Gene

Phenotypes From GWAS Catalog for NUDT6 Gene

Gene Ontology (GO) - Molecular Function for NUDT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity TAS 7984147
GO:0016787 hydrolase activity IEA --
GO:0035529 NADH pyrophosphatase activity IBA --
GO:0047631 ADP-ribose diphosphatase activity IBA --
GO:0051287 NAD binding IBA --
genes like me logo Genes that share ontologies with NUDT6: view
genes like me logo Genes that share phenotypes with NUDT6: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NUDT6 Gene

Localization for NUDT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT6 Gene

Cytoplasm. Nucleus. Mitochondrion. Note=Subcellular location may vary between isoforms.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT6 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytoskeleton 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NUDT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with NUDT6: view

Pathways & Interactions for NUDT6 Gene

genes like me logo Genes that share pathways with NUDT6: view

Gene Ontology (GO) - Biological Process for NUDT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0008150 biological_process ND --
GO:0010469 regulation of signaling receptor activity IEA --
genes like me logo Genes that share ontologies with NUDT6: view

No data available for SIGNOR curated interactions for NUDT6 Gene

Drugs & Compounds for NUDT6 Gene

(30) Drugs for NUDT6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(15) Additional Compounds for NUDT6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NUDT6: view

Transcripts for NUDT6 Gene

mRNA/cDNA for NUDT6 Gene

Unigene Clusters for NUDT6 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT6 Gene

No ASD Table

Relevant External Links for NUDT6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUDT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDT6 Gene

Protein differential expression in normal tissues from HIPED for NUDT6 Gene

This gene is overexpressed in Gallbladder (27.6), Liver (10.7), Kidney (10.2), and Heart (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT6 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUDT6 Gene:


SOURCE GeneReport for Unigene cluster for NUDT6 Gene:


mRNA Expression by UniProt/SwissProt for NUDT6 Gene:

Tissue specificity: Detected in liver, kidney and esophagus (at protein level). Ubiquitous.

Evidence on tissue expression from TISSUES for NUDT6 Gene

  • Liver(4.3)
  • Muscle(4.3)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with NUDT6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT6 Gene

Orthologs for NUDT6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDT6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NUDT6 34 33
  • 99.37 (n)
(Bos Taurus)
Mammalia NUDT6 34 33
  • 90.2 (n)
(Canis familiaris)
Mammalia NUDT6 34 33
  • 86.58 (n)
(Rattus norvegicus)
Mammalia Nudt6 33
  • 79.83 (n)
(Mus musculus)
Mammalia Nudt6 16 34 33
  • 77.01 (n)
(Monodelphis domestica)
Mammalia NUDT6 34
  • 66 (a)
(Gallus gallus)
Aves NUDT6 34 33
  • 75.93 (n)
(Anolis carolinensis)
Reptilia NUDT6 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt6 33
  • 69.01 (n)
Str.20390 33
(Danio rerio)
Actinopterygii nudt6 34 33
  • 60.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8128 34 35 33
  • 45.26 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012857 33
  • 43.21 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NUDT8 33
  • 48.91 (n)
(Oryza sativa)
Liliopsida Os04g0547900 33
  • 48.86 (n)
Species where no ortholog for NUDT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDT6 Gene

Gene Tree for NUDT6 (if available)
Gene Tree for NUDT6 (if available)
Evolutionary constrained regions (ECRs) for NUDT6: view image

Paralogs for NUDT6 Gene

No data available for Paralogs for NUDT6 Gene

Variants for NUDT6 Gene

Sequence variations from dbSNP and Humsavar for NUDT6 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs35430470 benign, Epilepsy, hearing loss, and mental retardation syndrome 122,923,222(-) G/C/T upstream_transcript_variant
rs765170329 uncertain-significance, Epilepsy, hearing loss, and mental retardation syndrome 122,923,144(-) T/A/C upstream_transcript_variant
rs552219028 pathogenic, not provided 122,923,143(-) A/C/G/T upstream_transcript_variant
rs1000181930 -- 122,904,291(-) T/C intron_variant
rs1000299804 -- 122,894,792(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT6 Gene

Variant ID Type Subtype PubMed ID
esv2657447 CNV deletion 23128226
esv3602036 CNV loss 21293372
esv3894022 CNV gain 25118596

Variation tolerance for NUDT6 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.58; 82.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT6 Gene

Disorders for NUDT6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NUDT6 Gene - From: HGMD, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NUDT6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NUDT6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NUDT6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDT6 Gene

Publications for NUDT6 Gene

  1. Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene. (PMID: 7984147) Murphy PR … Knee RS (Molecular endocrinology (Baltimore, Md.) 1994) 2 3 4 22 58
  2. The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production. (PMID: 11266510) Asa SL … Ezzat S (Molecular endocrinology (Baltimore, Md.) 2001) 3 4 22 58
  3. Characterization of the promoter for the human antisense fibroblast growth factor-2 gene; regulation by Ets in Jurkat T cells. (PMID: 10022609) Gagnon ML … Klagsbrun M (Journal of cellular biochemistry 1999) 2 3 4 58
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 44 58

Products for NUDT6 Gene

Sources for NUDT6 Gene

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