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Aliases for DNAJB4 Gene

Aliases for DNAJB4 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B4 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 4 2 3
  • Heat Shock 40 KDa Protein 1 Homolog 3 4
  • Heat Shock Protein 40 Homolog 3 4
  • Human Liver DnaJ-Like Protein 3 4
  • HSP40 Homolog 3 4
  • DNAJW 3 4
  • HLJ1 3 4
  • DnaJ Homolog Subfamily B Member 4 3
  • DnaJ-Like Heat Shock Protein 40 3
  • DjB4 3

External Ids for DNAJB4 Gene

Previous GeneCards Identifiers for DNAJB4 Gene

  • GC01P078623
  • GC01P077417
  • GC01P077835
  • GC01P077893
  • GC01P078182
  • GC01P078444
  • GC01P076602

Summaries for DNAJB4 Gene

Entrez Gene Summary for DNAJB4 Gene

  • The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for DNAJB4 Gene

DNAJB4 (DnaJ Heat Shock Protein Family (Hsp40) Member B4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and chaperone binding. An important paralog of this gene is DNAJB1.

UniProtKB/Swiss-Prot for DNAJB4 Gene

  • Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).

Gene Wiki entry for DNAJB4 Gene

Additional gene information for DNAJB4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB4 Gene

Genomics for DNAJB4 Gene

GeneHancer (GH) Regulatory Elements for DNAJB4 Gene

Promoters and enhancers for DNAJB4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J078002 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 661.9 +27.8 27754 8.6 HDGF HNRNPUL1 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 DNAJB4 FUBP1 RPL17P6 GIPC2 NEXN ENSG00000273338 LOC100131495
GH01J077975 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.9 -893 5.5 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 SSRP1 ZNF610 FUBP1 GIPC2 DNAJB4 USP33 RPL17P6 NEXN NEXN-AS1
GH01J078013 Promoter 0.5 EPDnew 650.3 +34.1 34095 0.1 DNAJB4 RNU6-1102P LOC100422537 ENSG00000273338 LOC100131495 GIPC2
GH01J078016 Promoter 0.5 EPDnew 650.3 +37.5 37532 0.1 DNAJB4 LOC100422537 RNU6-1102P ENSG00000273338 LOC100131495 GIPC2
GH01J077680 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 6.5 -296.3 -296278 4 CLOCK MLX ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 ZZZ3 FUBP1 RPL17P6 ENSG00000273338 NEXN GIPC2 AK5 DNAJB4 RN7SL370P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJB4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNAJB4 gene promoter:
  • c-Jun
  • ATF-2
  • AP-1
  • STAT3
  • Sox5
  • AML1a
  • FOXJ2

Genomic Locations for DNAJB4 Gene

Genomic Locations for DNAJB4 Gene
39,547 bases
Plus strand
38,790 bases
Plus strand

Genomic View for DNAJB4 Gene

Genes around DNAJB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB4 Gene

Proteins for DNAJB4 Gene

  • Protein details for DNAJB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily B member 4
    Protein Accession:
    Secondary Accessions:
    • B2R824
    • Q13431

    Protein attributes for DNAJB4 Gene

    337 amino acids
    Molecular mass:
    37807 Da
    Quaternary structure:
    • Homodimer. The C-terminal section interacts with the C-terminal tail of OPRM1. Interacts also with SDIM1.

neXtProt entry for DNAJB4 Gene

Post-translational modifications for DNAJB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJB4 Gene

No data available for DME Specific Peptides for DNAJB4 Gene

Domains & Families for DNAJB4 Gene

Gene Families for DNAJB4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DNAJB4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJB4: view

No data available for UniProtKB/Swiss-Prot for DNAJB4 Gene

Function for DNAJB4 Gene

Molecular function for DNAJB4 Gene

UniProtKB/Swiss-Prot Function:
Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).
UniProtKB/Swiss-Prot Induction:
By heat shock.

Phenotypes From GWAS Catalog for DNAJB4 Gene

Gene Ontology (GO) - Molecular Function for DNAJB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IDA 24318877
GO:0005515 protein binding IPI 21255413
GO:0051082 unfolded protein binding TAS,IEA --
GO:0051087 chaperone binding IPI 21231916
genes like me logo Genes that share ontologies with DNAJB4: view
genes like me logo Genes that share phenotypes with DNAJB4: view

Animal Model Products

miRNA for DNAJB4 Gene

miRTarBase miRNAs that target DNAJB4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB4 Gene

Localization for DNAJB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB4 Gene

Cytoplasm. Cell membrane. Note=Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJB4 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 4
nucleus 3
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DNAJB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 21231916
GO:0005886 plasma membrane IEA,IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DNAJB4: view

Pathways & Interactions for DNAJB4 Gene

SuperPathways for DNAJB4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0006986 response to unfolded protein TAS 9546042
GO:0009408 response to heat TAS 9546042
GO:0032781 positive regulation of ATPase activity IEA --
genes like me logo Genes that share ontologies with DNAJB4: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJB4 Gene

Drugs & Compounds for DNAJB4 Gene

No Compound Related Data Available

Transcripts for DNAJB4 Gene

Unigene Clusters for DNAJB4 Gene

DnaJ (Hsp40) homolog, subfamily B, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for DNAJB4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJB4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJB4 Gene

This gene is overexpressed in Rectum (7.3), Urinary Bladder (6.7), and Prostate (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DNAJB4 Gene

Protein tissue co-expression partners for DNAJB4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJB4 Gene:


SOURCE GeneReport for Unigene cluster for DNAJB4 Gene:


mRNA Expression by UniProt/SwissProt for DNAJB4 Gene:

Tissue specificity: Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver.

Evidence on tissue expression from TISSUES for DNAJB4 Gene

  • Liver(4.4)
  • Nervous system(3.9)
  • Heart(2.2)
  • Lung(2.2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with DNAJB4: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJB4 Gene

Orthologs for DNAJB4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNAJB4 34 33
  • 100 (n)
(Canis familiaris)
Mammalia DNAJB4 34 33
  • 95.65 (n)
(Bos Taurus)
Mammalia DNAJB4 34 33
  • 94.56 (n)
(Mus musculus)
Mammalia Dnajb4 16 34 33
  • 90.5 (n)
(Rattus norvegicus)
Mammalia Dnajb4 33
  • 88.53 (n)
(Ornithorhynchus anatinus)
Mammalia DNAJB4 34
  • 86 (a)
(Monodelphis domestica)
Mammalia DNAJB4 34
  • 85 (a)
(Gallus gallus)
Aves DNAJB4 34 33
  • 79.72 (n)
(Anolis carolinensis)
Reptilia DNAJB4 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb4 33
  • 75.66 (n)
(Danio rerio)
Actinopterygii dnajb4 34 33
  • 67.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta DnaJ-1 34 35 33
  • 55.9 (n)
CG5001 34 35
  • 52 (a)
CG2887 34 35
  • 45 (a)
CG12020 35
  • 28 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007107 33
  • 54.82 (n)
(Caenorhabditis elegans)
Secernentea dnj-13 34 33
  • 55.38 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIS1 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G25530 33
  • 50.61 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7032 33
(Oryza sativa)
Liliopsida Os02g0128400 33
  • 47.41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 57 (a)
Species where no ortholog for DNAJB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJB4 Gene

Gene Tree for DNAJB4 (if available)
Gene Tree for DNAJB4 (if available)
Evolutionary constrained regions (ECRs) for DNAJB4: view image

Paralogs for DNAJB4 Gene

Paralogs for DNAJB4 Gene

(23) SIMAP similar genes for DNAJB4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DNAJB4: view

Variants for DNAJB4 Gene

Sequence variations from dbSNP and Humsavar for DNAJB4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs587778373 not-provided, not specified 77,978,949(+) C/T upstream_transcript_variant
rs1000017085 -- 78,002,646(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000066176 -- 78,011,725(+) C/A intron_variant
rs1000078153 -- 78,000,965(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000193945 -- 77,991,295(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJB4 Gene

Variant ID Type Subtype PubMed ID
esv3586533 CNV loss 21293372

Variation tolerance for DNAJB4 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJB4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB4 Gene

Disorders for DNAJB4 Gene

Additional Disease Information for DNAJB4

No disorders were found for DNAJB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJB4 Gene

Publications for DNAJB4 Gene

  1. Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver. (PMID: 9546042) Hoe KL … Yoo HS (Biochimica et biophysica acta 1998) 2 3 4 22 58
  2. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. (PMID: 24318877) Rauch JN … Gestwicki JE (The Journal of biological chemistry 2014) 3 4 58
  3. A novel neuron-enriched protein SDIM1 is down regulated in Alzheimer's brains and attenuates cell death induced by DNAJB4 over-expression in neuro-progenitor cells. (PMID: 21255413) Lei JX … Liu QY (Molecular neurodegeneration 2011) 3 4 58
  4. [Preparation of the anti-HLJ1 monoclonal antibodies and establishment of method for detection of the antigen]. (PMID: 18837411) Lin X … Wang X (Sheng wu gong cheng xue bao = Chinese journal of biotechnology 2008) 4 22 58
  5. A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor. (PMID: 16542645) Ancevska-Taneva N … Simon EJ (Brain research 2006) 3 4 58

Products for DNAJB4 Gene

Sources for DNAJB4 Gene

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