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Aliases for CPSF6 Gene

Aliases for CPSF6 Gene

  • Cleavage And Polyadenylation Specific Factor 6 2 3 5
  • Cleavage Factor Im Complex 68 KDa Subunit 2 3 4
  • Cleavage And Polyadenylation Specificity Factor 68 KDa Subunit 3 4
  • Cleavage And Polyadenylation Specific Factor 6, 68kDa 2 3
  • Pre-MRNA Cleavage Factor Im 68 KDa Subunit 3 4
  • CPSF 68 KDa Subunit 3 4
  • Protein HPBRII-4/7 3 4
  • CFIM68 3 4
  • Cleavage And Polyadenylation Specific Factor 6, 68kD Subunit 2
  • Cleavage And Polyadenylation Specificity Factor Subunit 6 3
  • Pre-MRNA Cleavage Factor I, 68kD Subunit 3
  • Pre-MRNA Cleavage Factor Im (68kD) 3
  • HPBRII-4 3
  • HPBRII-7 3
  • CFIM72 3
  • CFIm68 4
  • CFIM 3

External Ids for CPSF6 Gene

Previous GeneCards Identifiers for CPSF6 Gene

  • GC12M069604
  • GC12P069573
  • GC12P069350
  • GC12P067919
  • GC12P069633

Summaries for CPSF6 Gene

Entrez Gene Summary for CPSF6 Gene

  • The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPSF6 Gene

CPSF6 (Cleavage And Polyadenylation Specific Factor 6) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and FGFR1 mutant receptor activation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CPSF7.

UniProtKB/Swiss-Prot for CPSF6 Gene

  • Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5-UGUA-3 elements localized in the 3-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5-UGUA-3 elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460).

Gene Wiki entry for CPSF6 Gene

Additional gene information for CPSF6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF6 Gene

Genomics for CPSF6 Gene

GeneHancer (GH) Regulatory Elements for CPSF6 Gene

Promoters and enhancers for CPSF6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J069238 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 674.5 +0.5 493 3.1 HDGF CLOCK SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B CPSF6 LYZ NUP107 RAP1B MDM2 YEATS4 FRS2 CCT2 SLC35E3 RAB3IP
GH12J068685 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 42.8 -552.7 -552707 3 MLX DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ZC3H11A NUP107 LOC100507250 CPSF6 KRT8P39 RPL10P12 MDM2 RPL7P42
GH12J068803 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE 33.7 -432.8 -432835 7 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MDM2 LOC100130075 NUP107 CPSF6 KRT8P39 RPL10P12 RAP1B RPL7P42 ENSG00000258140 ENSG00000256273
GH12J069584 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 30.9 +346.1 346109 1.8 HDGF PKNOX1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B CCT2 MIR3913-2 MIR3913-1 CPSF6 NUP107 CNOT2 FRS2 RAP1B LYZ LRRC10
GH12J068361 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 34.4 -874.2 -874199 7 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A IRF4 YY1 POLR2B ZNF143 NUP107 CPSF6 MDM1 LINC02384 SNORA70G RPL10P12 KRT8P39 RPL7P42 LOC100507250 RAP1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CPSF6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPSF6 gene promoter:
  • Elk-1
  • AML1a
  • STAT3
  • MAZR
  • Cart-1
  • HEN1
  • NF-1
  • NF-1/L
  • Pax-4a
  • E47

Genomic Locations for CPSF6 Gene

Genomic Locations for CPSF6 Gene
chr12:69,239,537-69,274,358
(GRCh38/hg38)
Size:
34,822 bases
Orientation:
Plus strand
chr12:69,633,317-69,668,138
(GRCh37/hg19)
Size:
34,822 bases
Orientation:
Plus strand

Genomic View for CPSF6 Gene

Genes around CPSF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPSF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPSF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPSF6 Gene

Proteins for CPSF6 Gene

  • Protein details for CPSF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16630-CPSF6_HUMAN
    Recommended name:
    Cleavage and polyadenylation specificity factor subunit 6
    Protein Accession:
    Q16630
    Secondary Accessions:
    • A8K7K9
    • Q53ES1
    • Q9BSJ7
    • Q9BW18

    Protein attributes for CPSF6 Gene

    Size:
    551 amino acids
    Molecular mass:
    59210 Da
    Quaternary structure:
    • Component of the cleavage factor Im (CFIm) complex which is an heterotetramer composed of two subunits of NUDT21/CPSF5 and two subunits of CPSF6 or CPSF7 or an heterodimer of CPSF6 and CPSF7 (PubMed:9659921, PubMed:8626397, PubMed:14561889, PubMed:20695905, PubMed:23187700). The cleavage factor Im (CFIm) complex associates with the CPSF and CSTF complexes to promote the assembly of the core mRNA 3-processing machinery (PubMed:29276085). Associates with the exon junction complex (EJC) (PubMed:19864460). Associates with the 80S ribosome particle (PubMed:19864460). Interacts (via the RRM domain) with NUDT21/CPSF5; this interaction is direct and enhances binding to RNA (PubMed:14561889, PubMed:15169763, PubMed:19864460, PubMed:29276085, PubMed:21295486). Interacts (via Arg/Ser-rich domain) with FIP1L1 (preferentially via unphosphorylated form and Arg/Glu/Asp-rich domain); this interaction mediates, at least in part, the interaction between the CFIm and CPSF complexes and may be inhibited by CPSF6 hyper-phosphorylation (PubMed:29276085). Interacts (via N-terminus) with NXF1; this interaction is direct (PubMed:19864460). Interacts with SRSF3 (PubMed:15169763). Interacts with SRSF7 (PubMed:15169763). Interacts with SNRNP70 (PubMed:14561889). Interacts with TRA2B/SFRS10 (PubMed:15169763). Interacts with UPF1 (PubMed:19864460). Interacts with UPF3B (PubMed:19864460).

    Three dimensional structures from OCA and Proteopedia for CPSF6 Gene

    Alternative splice isoforms for CPSF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPSF6 Gene

Post-translational modifications for CPSF6 Gene

  • Phosphorylated (PubMed:29276085). Phosphorylated in the Arg/Ser-rich domain by SRPK1, in vitro (PubMed:29276085).
  • Symmetrically dimethylated on arginine residues in the GAR motif by PRMT5 in a WDR77- and CLNS1A-dependent manner (PubMed:20562214). Asymmetrically dimethylated on arginine residues in the GAR motif by PRMT1 (PubMed:20562214).
  • Ubiquitination at posLast=185185, Lys161, and Lys79
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for CPSF6
  • Boster Bio Antibodies for CPSF6

No data available for DME Specific Peptides for CPSF6 Gene

Domains & Families for CPSF6 Gene

Gene Families for CPSF6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CPSF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16630

UniProtKB/Swiss-Prot:

CPSF6_HUMAN :
  • Contains an Arg/Ser-rich domain composed of arginine-serine dipeptide repeats within the C-terminal region that is necessary and sufficient for activating mRNA 3-processing and alternative polyadenylation (APA).
  • Belongs to the RRM CPSF6/7 family.
Domain:
  • Contains an Arg/Ser-rich domain composed of arginine-serine dipeptide repeats within the C-terminal region that is necessary and sufficient for activating mRNA 3-processing and alternative polyadenylation (APA).
Family:
  • Belongs to the RRM CPSF6/7 family.
genes like me logo Genes that share domains with CPSF6: view

Function for CPSF6 Gene

Molecular function for CPSF6 Gene

UniProtKB/Swiss-Prot Function:
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5-UGUA-3 elements localized in the 3-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5-UGUA-3 elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460).

Phenotypes From GWAS Catalog for CPSF6 Gene

Gene Ontology (GO) - Molecular Function for CPSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 contributes_to RNA binding IEA,IDA 15169763
GO:0003729 mRNA binding IDA 21295486
GO:0005515 protein binding IPI 14561889
GO:0043023 ribosomal large subunit binding IDA 19864460
GO:1990448 exon-exon junction complex binding IDA 19864460
genes like me logo Genes that share ontologies with CPSF6: view
genes like me logo Genes that share phenotypes with CPSF6: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPSF6 Gene

Localization for CPSF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPSF6 Gene

Nucleus. Nucleus, nucleoplasm. Nucleus speckle. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm) (PubMed:19864460). Colocalizes with PSPC1 in punctate subnuclear structures often located adjacent to nuclear speckles, called paraspeckles, and corresponding to interchromatin granules-associated zones (IGAZs) (PubMed:17267687). Distribution in speckles and paraspeckles varies during the cell cycle (PubMed:17267687). Associates at sites of active transcription on nascent perichromatin fibrils (PFs) and perichromatin granules (PubMed:17267687). {ECO:0000269 PubMed:15169763, ECO:0000269 PubMed:17267687, ECO:0000269 PubMed:19864460}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPSF6 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CPSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 19864460
GO:0005654 nucleoplasm IDA 17267687
GO:0005726 perichromatin fibrils IDA 17267687
GO:0005737 cytoplasm IDA 19864460
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IDA 23187700
genes like me logo Genes that share ontologies with CPSF6: view

Pathways & Interactions for CPSF6 Gene

genes like me logo Genes that share pathways with CPSF6: view

Gene Ontology (GO) - Biological Process for CPSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006378 mRNA polyadenylation IMP 20695905
GO:0006397 mRNA processing IDA,IEA 14690600
GO:0046833 positive regulation of RNA export from nucleus IMP 19864460
GO:0051262 protein tetramerization IDA 20695905
GO:0051290 protein heterotetramerization IDA 23187700
genes like me logo Genes that share ontologies with CPSF6: view

No data available for SIGNOR curated interactions for CPSF6 Gene

Drugs & Compounds for CPSF6 Gene

No Compound Related Data Available

Transcripts for CPSF6 Gene

mRNA/cDNA for CPSF6 Gene

Unigene Clusters for CPSF6 Gene

Cleavage and polyadenylation specific factor 6, 68kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF6 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6: -
SP7:
SP8:

Relevant External Links for CPSF6 Gene

GeneLoc Exon Structure for
CPSF6
ECgene alternative splicing isoforms for
CPSF6

Expression for CPSF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPSF6 Gene

Protein differential expression in normal tissues from HIPED for CPSF6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPSF6 Gene



Protein tissue co-expression partners for CPSF6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CPSF6 Gene:

CPSF6

SOURCE GeneReport for Unigene cluster for CPSF6 Gene:

Hs.369606

Evidence on tissue expression from TISSUES for CPSF6 Gene

  • Pancreas(5)
  • Heart(4.3)
  • Kidney(4.3)
  • Liver(4.3)
  • Spleen(4.3)
  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with CPSF6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPSF6 Gene

Orthologs for CPSF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPSF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPSF6 34 33
  • 99.58 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPSF6 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPSF6 34 33
  • 96.13 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpsf6 33
  • 93.47 (n)
dog
(Canis familiaris)
Mammalia CPSF6 34 33
  • 92.96 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cpsf6 16 34 33
  • 92.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF6 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPSF6 34 33
  • 84.74 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPSF6 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17115 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7296 33
zebrafish
(Danio rerio)
Actinopterygii cpsf6 34
  • 83 (a)
OneToOne
Dr.28441 33
fruit fly
(Drosophila melanogaster)
Insecta CG7185 34
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cfim-2 34
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
OneToMany
Cin.3009 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3009 33
Species where no ortholog for CPSF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPSF6 Gene

ENSEMBL:
Gene Tree for CPSF6 (if available)
TreeFam:
Gene Tree for CPSF6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CPSF6: view image

Paralogs for CPSF6 Gene

Paralogs for CPSF6 Gene

(1) SIMAP similar genes for CPSF6 Gene using alignment to 5 proteins:

  • CPSF6_HUMAN
  • F8VNP8_HUMAN
  • F8W084_HUMAN
  • F8WJN3_HUMAN
  • L8E8D6_HUMAN

Pseudogenes.org Pseudogenes for CPSF6 Gene

genes like me logo Genes that share paralogs with CPSF6: view

Variants for CPSF6 Gene

Sequence variations from dbSNP and Humsavar for CPSF6 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000036530 -- 69,242,320(+) A/T intron_variant
rs1000088484 -- 69,242,652(+) C/G intron_variant
rs1000199292 -- 69,257,205(+) T/C intron_variant
rs1000206522 -- 69,267,505(+) A/C intron_variant
rs1000241726 -- 69,248,727(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CPSF6 Gene

Variant ID Type Subtype PubMed ID
esv3394226 CNV duplication 20981092

Variation tolerance for CPSF6 Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPSF6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPSF6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPSF6 Gene

Disorders for CPSF6 Gene

Additional Disease Information for CPSF6

No disorders were found for CPSF6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPSF6 Gene

Publications for CPSF6 Gene

  1. Subnuclear localization and dynamics of the Pre-mRNA 3' end processing factor mammalian cleavage factor I 68-kDa subunit. (PMID: 17267687) Cardinale S … Barabino SM (Molecular biology of the cell 2007) 2 3 4 58
  2. Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits. (PMID: 9659921) Rüegsegger U … Keller W (Molecular cell 1998) 2 3 4 58
  3. Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation. (PMID: 29276085) Zhu Y … Shi Y (Molecular cell 2018) 3 4 58
  4. Cleavage factor Im is a key regulator of 3' UTR length. (PMID: 23187700) Gruber AR … Zavolan M (RNA biology 2012) 3 4 58
  5. Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping. (PMID: 21295486) Yang Q … Doublié S (Structure (London, England : 1993) 2011) 3 4 58

Products for CPSF6 Gene

Sources for CPSF6 Gene

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