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Aliases for LILRA1 Gene

Aliases for LILRA1 Gene

  • Leukocyte Immunoglobulin Like Receptor A1 2 3 5
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 1 2 3
  • Leukocyte Immunoglobulin-Like Receptor 6 3 4
  • CD85 Antigen-Like Family Member I 3 4
  • Leucocyte Ig-Like Receptor A1 2 3
  • LIR-6 3 4
  • LIR6 3 4
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 1 3
  • CD85i Antigen 4
  • CD85I 3

External Ids for LILRA1 Gene

Previous GeneCards Identifiers for LILRA1 Gene

  • GC19P055968
  • GC19M055529
  • GC19P059781
  • GC19P059796
  • GC19P055105
  • GC19P051428

Summaries for LILRA1 Gene

Entrez Gene Summary for LILRA1 Gene

  • This gene encodes an activating member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein is predominantly expressed in B cells, interacts with major histocompatibility complex class I ligands, and contributes to the regulation of immune responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

GeneCards Summary for LILRA1 Gene

LILRA1 (Leukocyte Immunoglobulin Like Receptor A1) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Osteoclast differentiation. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and antigen binding. An important paralog of this gene is LILRA2.

UniProtKB/Swiss-Prot for LILRA1 Gene

  • May act as receptor for class I MHC antigens.

Additional gene information for LILRA1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRA1 Gene

Genomics for LILRA1 Gene

GeneHancer (GH) Regulatory Elements for LILRA1 Gene

Promoters and enhancers for LILRA1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J054592 Promoter/Enhancer 0.7 EPDnew Ensembl 665.4 +0.3 325 2.2 LILRA1 LILRA2 ENSG00000269271 ENSG00000238094
GH19J054199 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.5 -387.9 -387866 12.1 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 RPS9 PRPF31 LENG8 CNOT3 LENG8-AS1 ZNF525 ZNF845 ENSG00000235681 LILRB5 ZNF765
GH19J054642 Promoter/Enhancer 1.4 EPDnew FANTOM5 Ensembl ENCODE 17 +50.3 50325 2.6 ZNF316 PRDM10 LILRB4 MIR8061 LILRA1 LAIR1 FCAR LILRB1 LILRB3 LILRA2 LILRB2 LILRA5
GH19J054873 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE 12.7 +282.6 282608 5.2 GATA3 ZNF157 POLR2A SPI1 FCAR LILRA2 KIR2DS4 LILRA1 NLRP2 NLRP7 ENSG00000243494 KIR2DL3 EPS8L1 RDH13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LILRA1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LILRA1 gene promoter:
  • AML1a

Genomic Locations for LILRA1 Gene

Genomic Locations for LILRA1 Gene
9,149 bases
Plus strand
8,509 bases
Plus strand

Genomic View for LILRA1 Gene

Genes around LILRA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LILRA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LILRA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRA1 Gene

Proteins for LILRA1 Gene

  • Protein details for LILRA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 1
    Protein Accession:
    Secondary Accessions:
    • O75018
    • Q3MJA6

    Protein attributes for LILRA1 Gene

    489 amino acids
    Molecular mass:
    53275 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LILRA1 Gene


neXtProt entry for LILRA1 Gene

Post-translational modifications for LILRA1 Gene

  • Glycosylation at posLast=448448, posLast=431431, posLast=341341, isoforms=302, posLast=281281, and isoforms=2140
  • Modification sites at PhosphoSitePlus

Other Protein References for LILRA1 Gene

No data available for DME Specific Peptides for LILRA1 Gene

Domains & Families for LILRA1 Gene

Gene Families for LILRA1 Gene

Suggested Antigen Peptide Sequences for LILRA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LILRA1: view

No data available for UniProtKB/Swiss-Prot for LILRA1 Gene

Function for LILRA1 Gene

Molecular function for LILRA1 Gene

UniProtKB/Swiss-Prot Function:
May act as receptor for class I MHC antigens.
GENATLAS Biochemistry:
leukocyte immunoglobulin-like receptor,subfamily A,member 1,predominantly expressed on monocytes and B cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily,with two (and others ?) alternatively spliced isoforms

Phenotypes From GWAS Catalog for LILRA1 Gene

Gene Ontology (GO) - Molecular Function for LILRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding TAS 9548455
GO:0004888 transmembrane signaling receptor activity TAS 9548455
genes like me logo Genes that share ontologies with LILRA1: view
genes like me logo Genes that share phenotypes with LILRA1: view

Animal Model Products

miRNA for LILRA1 Gene

miRTarBase miRNAs that target LILRA1

Clone Products

  • R&D Systems cDNA Clones for LILRA1 (LILRA1/CD85i/LIR-6)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LILRA1 Gene

Localization for LILRA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LILRA1 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LILRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LILRA1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LILRA1 Gene

Pathways & Interactions for LILRA1 Gene

genes like me logo Genes that share pathways with LILRA1: view

Pathways by source for LILRA1 Gene

Interacting Proteins for LILRA1 Gene

Gene Ontology (GO) - Biological Process for LILRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006952 defense response TAS 9548455
GO:0007166 cell surface receptor signaling pathway TAS 9548455
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with LILRA1: view

No data available for SIGNOR curated interactions for LILRA1 Gene

Drugs & Compounds for LILRA1 Gene

No Compound Related Data Available

Transcripts for LILRA1 Gene

mRNA/cDNA for LILRA1 Gene

(3) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LILRA1 Gene

Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for LILRA1 (LILRA1/CD85i/LIR-6)

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA1 Gene

No ASD Table

Relevant External Links for LILRA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LILRA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LILRA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LILRA1 Gene

This gene is overexpressed in Whole Blood (x33.5) and Spleen (x7.3).

Protein differential expression in normal tissues from HIPED for LILRA1 Gene

This gene is overexpressed in Nasal epithelium (54.3) and Serum (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LILRA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of LILRA1 Gene:


SOURCE GeneReport for Unigene cluster for LILRA1 Gene:


mRNA Expression by UniProt/SwissProt for LILRA1 Gene:

Tissue specificity: Detected in monocytes and B-cells.

Evidence on tissue expression from TISSUES for LILRA1 Gene

  • Blood(4.3)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with LILRA1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LILRA1 Gene

Orthologs for LILRA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LILRA3 33
  • 91.03 (n)
  • 68 (a)
(Bos Taurus)
Mammalia -- 34
  • 52 (a)
(Canis familiaris)
Mammalia -- 34
  • 33 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 20 (a)
Species where no ortholog for LILRA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRA1 Gene

Gene Tree for LILRA1 (if available)
Gene Tree for LILRA1 (if available)

Paralogs for LILRA1 Gene

Variants for LILRA1 Gene

Sequence variations from dbSNP and Humsavar for LILRA1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000024978 -- 54,597,053(+) C/T intron_variant
rs1000034909 -- 54,597,180(+) T/C intron_variant
rs1001087448 -- 54,598,164(+) G/A intron_variant
rs1001358288 -- 54,593,790(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001959545 -- 54,594,714(+) C/G coding_sequence_variant, non_coding_transcript_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for LILRA1 Gene

Variant ID Type Subtype PubMed ID
dgv16e196 CNV duplication 17116639
dgv17e196 CNV deletion 17116639
dgv3664n100 CNV gain 25217958
dgv435n27 CNV loss 19166990
dgv6563n54 CNV loss 21841781
esv2304491 CNV deletion 18987734
esv2667609 CNV deletion 23128226
esv2718872 CNV deletion 23290073
esv2758771 CNV gain+loss 17122850
esv2762051 CNV loss 21179565
esv3583532 CNV loss 25503493
esv7755 CNV loss 19470904
nsv1065887 CNV loss 25217958
nsv1148744 OTHER inversion 26484159
nsv428372 CNV gain+loss 18775914
nsv470158 CNV loss 18288195
nsv516569 CNV gain+loss 19592680
nsv522872 CNV loss 19592680
nsv961248 CNV duplication 23825009
nsv961249 CNV duplication 23825009

Variation tolerance for LILRA1 Gene

Residual Variation Intolerance Score: 98.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.32; 90.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LILRA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRA1 Gene

Disorders for LILRA1 Gene

Additional Disease Information for LILRA1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LILRA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LILRA1 Gene

Publications for LILRA1 Gene

  1. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PMID: 9548455) Borges L … Cosman D (Journal of immunology (Baltimore, Md. : 1950) 1997) 2 3 4 58
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4. (PMID: 10941837) Liu WR … Arm JP (Immunogenetics 2000) 3 22 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for LILRA1 Gene

Sources for LILRA1 Gene

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