Aliases for LILRB5 Gene
External Ids for LILRB5 Gene
Previous GeneCards Identifiers for LILRB5 Gene
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for LILRB5 Gene
LILRB5 (Leukocyte Immunoglobulin Like Receptor B5) is a Protein Coding gene. Among its related pathways are Innate Immune System and Osteoclast differentiation. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is LILRB1.
UniProtKB/Swiss-Prot for LILRB5 Gene
May act as receptor for class I MHC antigens.