Aliases for SEC61B Gene
External Ids for SEC61B Gene
Previous GeneCards Identifiers for SEC61B Gene
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008]
GeneCards Summary for SEC61B Gene
SEC61B (Sec61 Translocon Beta Subunit) is a Protein Coding gene. Diseases associated with SEC61B include Myasthenic Syndrome, Congenital, 14. Among its related pathways are Protein processing in endoplasmic reticulum and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include epidermal growth factor binding.
UniProtKB/Swiss-Prot for SEC61B Gene
Necessary for protein translocation in the endoplasmic reticulum.