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Aliases for BTG3 Gene

Aliases for BTG3 Gene

  • BTG Anti-Proliferation Factor 3 2 3 5
  • BTG Family Member 3 2 3 4
  • Abundant In Neuroepithelium Area Protein 3 4
  • Protein Tob5 3 4
  • TOB5 3 4
  • ANA 3 4
  • B-Cell Translocation Gene 3 3
  • BTG Family, Member 3 2
  • Protein BTG3 3
  • ANA/BTG3 3
  • APRO4 3
  • TOB55 3
  • TOFA 3

External Ids for BTG3 Gene

Previous GeneCards Identifiers for BTG3 Gene

  • GC21M015630
  • GC21M017887
  • GC21M018965
  • GC21M004351

Summaries for BTG3 Gene

Entrez Gene Summary for BTG3 Gene

  • The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for BTG3 Gene

BTG3 (BTG Anti-Proliferation Factor 3) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay. An important paralog of this gene is BTG4.

UniProtKB/Swiss-Prot for BTG3 Gene

  • Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.

Gene Wiki entry for BTG3 Gene

Additional gene information for BTG3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTG3 Gene

Genomics for BTG3 Gene

GeneHancer (GH) Regulatory Elements for BTG3 Gene

Promoters and enhancers for BTG3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J017610 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.8 799 3.4 ATF1 BRCA1 YY1 POLR2B GLIS2 ZNF213 ZNF207 ZNF143 FOS ATF7 GC21P017613 BTG3-AS1 BTG3 CXADR
GH21J017779 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5.4 -170.8 -170807 8.7 HDGF FOXA2 IRF4 ZNF143 ATF7 FOS RUNX3 JUNB NFIL3 NBN C21orf91-OT1 C21orf91 BTG3 LOC105372741
GH21J017660 Enhancer 0.3 ENCODE 16.2 -47.7 -47708 0.2 CEBPB ENSG00000226956 BTG3 GC21M017663
GH21J017607 Enhancer 0.4 ENCODE 5.3 +4.9 4874 1.9 ZBTB12 TRIM28 BTG3 BTG3-AS1 ENSG00000199962 CXADR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BTG3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BTG3 gene promoter:
  • p53
  • STAT5A
  • STAT1
  • STAT1alpha
  • STAT1beta
  • Pax-4a
  • FOXO4
  • HOXA9B
  • AML1a

Genomic Locations for BTG3 Gene

Genomic Locations for BTG3 Gene
19,301 bases
Minus strand
19,301 bases
Minus strand

Genomic View for BTG3 Gene

Genes around BTG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTG3 Gene

Proteins for BTG3 Gene

  • Protein details for BTG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein BTG3
    Protein Accession:
    Secondary Accessions:
    • D3DSC4
    • Q53XV1
    • Q96ET7

    Protein attributes for BTG3 Gene

    252 amino acids
    Molecular mass:
    29116 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTG3 Gene


neXtProt entry for BTG3 Gene

Post-translational modifications for BTG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BTG3 Gene

Domains & Families for BTG3 Gene

Gene Families for BTG3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BTG3 Gene

Suggested Antigen Peptide Sequences for BTG3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BTG family.
  • Belongs to the BTG family.
genes like me logo Genes that share domains with BTG3: view

Function for BTG3 Gene

Molecular function for BTG3 Gene

UniProtKB/Swiss-Prot Function:
Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.
GENATLAS Biochemistry:
B cell transcription gene 3,antiproliferative,predominantly expressed in ovary,testis,prostate,thymus,lung,putatively involved in neurogenesis in the central nervous system,Tob/BTG1 family

Phenotypes From GWAS Catalog for BTG3 Gene

Gene Ontology (GO) - Molecular Function for BTG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17690688
genes like me logo Genes that share ontologies with BTG3: view
genes like me logo Genes that share phenotypes with BTG3: view

Animal Models for BTG3 Gene

MGI Knock Outs for BTG3:

Animal Model Products

  • Taconic Biosciences Mouse Models for BTG3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BTG3 Gene

Localization for BTG3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTG3 gene
Compartment Confidence
cytosol 3
extracellular 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for BTG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IDA 9632145
genes like me logo Genes that share ontologies with BTG3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for BTG3 Gene

Pathways & Interactions for BTG3 Gene

SuperPathway Contained pathways
1 Deadenylation-dependent mRNA decay
genes like me logo Genes that share pathways with BTG3: view

Pathways by source for BTG3 Gene

1 KEGG pathway for BTG3 Gene

Gene Ontology (GO) - Biological Process for BTG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation TAS 9632145
GO:0045930 negative regulation of mitotic cell cycle IDA 9632145
genes like me logo Genes that share ontologies with BTG3: view

No data available for SIGNOR curated interactions for BTG3 Gene

Drugs & Compounds for BTG3 Gene

No Compound Related Data Available

Transcripts for BTG3 Gene

Unigene Clusters for BTG3 Gene

BTG family, member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTG3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c
SP1: - - - -
SP2: - -
SP3: - - -
SP5: - - - -

Relevant External Links for BTG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BTG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BTG3 Gene

This gene is overexpressed in Spinal cord (38.5), CD8 Tcells (15.9), Urinary Bladder (7.8), and Retina (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BTG3 Gene

Protein tissue co-expression partners for BTG3 Gene

NURSA nuclear receptor signaling pathways regulating expression of BTG3 Gene:


SOURCE GeneReport for Unigene cluster for BTG3 Gene:


mRNA Expression by UniProt/SwissProt for BTG3 Gene:

Tissue specificity: Ubiquitous. High expression in the ventricular zone of the developing central nervous system. High in ovary, testis, prostate, thymus and lung.

Evidence on tissue expression from TISSUES for BTG3 Gene

  • Nervous system(2)
genes like me logo Genes that share expression patterns with BTG3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTG3 Gene

Orthologs for BTG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTG3 34 33
  • 99.55 (n)
(Canis familiaris)
Mammalia BTG3 34
  • 98 (a)
LOC487695 33
  • 93.92 (n)
(Mus musculus)
Mammalia Gm7334 34
  • 94 (a)
Btg3 16 34 33
  • 91.4 (n)
(Bos Taurus)
Mammalia BTG3 34 33
  • 92.46 (n)
(Rattus norvegicus)
Mammalia Btg3 33
  • 90.87 (n)
(Ornithorhynchus anatinus)
Mammalia BTG3 34
  • 59 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 34 (a)
(Gallus gallus)
Aves -- 34
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia btg3 33
  • 61.92 (n)
Str.6608 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.31129 33
(Danio rerio)
Actinopterygii btg3 34 33
  • 65.03 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta Tob 34
  • 11 (a)
Species where no ortholog for BTG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTG3 Gene

Gene Tree for BTG3 (if available)
Gene Tree for BTG3 (if available)
Evolutionary constrained regions (ECRs) for BTG3: view image

Paralogs for BTG3 Gene

Paralogs for BTG3 Gene

(3) SIMAP similar genes for BTG3 Gene using alignment to 3 proteins:

  • Q6IAU3_HUMAN Pseudogenes for BTG3 Gene

genes like me logo Genes that share paralogs with BTG3: view

Variants for BTG3 Gene

Sequence variations from dbSNP and Humsavar for BTG3 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000020256 -- 17,610,560(-) T/A/C intron_variant
rs1000102016 -- 17,604,461(-) A/G intron_variant
rs1000125191 -- 17,603,767(-) T/C intron_variant
rs1000191305 -- 17,602,234(-) G/T intron_variant
rs1000334121 -- 17,597,513(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BTG3 Gene

Variant ID Type Subtype PubMed ID
dgv4391n100 CNV gain 25217958
esv2723192 CNV deletion 23290073
esv3575381 CNV gain 25503493
esv3893382 CNV gain 25118596

Variation tolerance for BTG3 Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BTG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTG3 Gene

Disorders for BTG3 Gene

Additional Disease Information for BTG3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BTG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTG3 Gene

Publications for BTG3 Gene

  1. ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system. (PMID: 9632145) Yoshida Y … Yamamoto T (Oncogene 1998) 2 3 4 58
  2. Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle. (PMID: 9067576) Guéhenneux F … Rouault JP (Leukemia 1997) 3 4 22 58
  3. BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. (PMID: 19221000) Majid S … Dahiya R (Carcinogenesis 2009) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. (PMID: 11429045) Yoshida Y … Yamamoto T (Japanese journal of cancer research : Gann 2001) 3 22 58

Products for BTG3 Gene

Sources for BTG3 Gene

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