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Aliases for MORF4L1 Gene

Aliases for MORF4L1 Gene

  • Mortality Factor 4 Like 1 2 3 5
  • Transcription Factor-Like Protein MRG15 3 4
  • MORF-Related Gene On Chromosome 15 2 3
  • MORF-Related Gene 15 Protein 3 4
  • Protein MSL3-1 3 4
  • MRG15 3 4
  • Esa1p-Associated Factor 3 Homolog (S. Cerevisiae) 2
  • Esa1p-Associated Factor 3 Homolog 3
  • Mortality Factor 4-Like Protein 1 3
  • HsT17725 3
  • MORFRG15 3
  • FWP006 3
  • S863-6 3
  • MEAF3 3
  • Eaf3 3

External Ids for MORF4L1 Gene

Previous GeneCards Identifiers for MORF4L1 Gene

  • GC15P072322
  • GC15P076678
  • GC15P076881
  • GC15P076952
  • GC15P079132
  • GC15P079102

Summaries for MORF4L1 Gene

GeneCards Summary for MORF4L1 Gene

MORF4L1 (Mortality Factor 4 Like 1) is a Protein Coding gene. Diseases associated with MORF4L1 include Paraneoplastic Cerebellar Degeneration. Among its related pathways are Chromatin organization and Pathways Affected in Adenoid Cystic Carcinoma. Gene Ontology (GO) annotations related to this gene include chromatin binding and protein N-terminus binding. An important paralog of this gene is MORF4L2.

UniProtKB/Swiss-Prot for MORF4L1 Gene

  • Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.

Gene Wiki entry for MORF4L1 Gene

Additional gene information for MORF4L1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MORF4L1 Gene

Genomics for MORF4L1 Gene

GeneHancer (GH) Regulatory Elements for MORF4L1 Gene

Promoters and enhancers for MORF4L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J078871 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 658.4 +63.3 63320 4.6 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC ZNF610 ZNF585B GLIS1 RCOR2 MORF4L1 IREB2 ENSG00000259562 PSMA4 TBC1D2B RNU6-415P ENSG00000260988 WDR61 ENSG00000177699 ENSG00000259322
GH15J078810 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 650.7 +0.7 728 2.4 INSM2 SIN3A ZNF335 GLIS2 ZNF366 ZNF143 KLF13 ZBTB11 ZNF398 ZFP69B MORF4L1 ADAMTS7
GH15J078858 Enhancer 1.8 VISTA FANTOM5 Ensembl ENCODE dbSUPER 17.4 +49.9 49869 3.4 MLX SIN3A IRF4 BRCA1 NCOA2 YY1 ETS1 GTF3C2 ZNF121 ZNF213 TRK-CTT1-2 IREB2 ENSG00000259562 ADAMTS7 MORF4L1 ENSG00000259322 WDR61 TBC1D2B ADAMTS7P3 CTSH
GH15J078564 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 9.4 -244.7 -244660 2.2 HDGF ARNT ARID4B SIN3A TCF12 ELK1 ZNF143 SP3 NCOA1 SREBF1 CHRNA5 PSMA4 IREB2 TBC1D2B HYKK MORF4L1 ADAMTS7 CRABP1 RASGRF1 ENSG00000261762
GH15J078720 Enhancer 0.9 Ensembl 11.1 -90.3 -90286 0.4 PKNOX1 FOXA2 KLF17 SIN3A KLF14 ZBTB7B RARA YY1 ZNF213 EGR1 CHRNA5 ADAMTS7 MORF4L1 ADAMTS7P3 CHRNB4 LOC105370913 GC15M078021 LOC646934
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MORF4L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MORF4L1 gene promoter:
  • ARP-1
  • p53
  • Zic1
  • ATF
  • Spz1
  • FOXC1
  • Hlf
  • Ik-3
  • POU2F1
  • POU2F1a

Genomic Locations for MORF4L1 Gene

Genomic Locations for MORF4L1 Gene
chr15:78,810,487-78,898,133
(GRCh38/hg38)
Size:
87,647 bases
Orientation:
Plus strand
chr15:79,102,829-79,190,475
(GRCh37/hg19)
Size:
87,647 bases
Orientation:
Plus strand

Genomic View for MORF4L1 Gene

Genes around MORF4L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MORF4L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MORF4L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORF4L1 Gene

Proteins for MORF4L1 Gene

  • Protein details for MORF4L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBU8-MO4L1_HUMAN
    Recommended name:
    Mortality factor 4-like protein 1
    Protein Accession:
    Q9UBU8
    Secondary Accessions:
    • B4DKN6
    • B7Z6R1
    • D3DW88
    • O95899
    • Q5QTS1
    • Q6NVX8
    • Q86YT7
    • Q9HBP6
    • Q9NSW5

    Protein attributes for MORF4L1 Gene

    Size:
    362 amino acids
    Molecular mass:
    41474 Da
    Quaternary structure:
    • Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the mSin3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with RB1 and KAT8. May also interact with PHF12 and one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors. Interacts with the N-terminus of MRFAP1. Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts with the entire BRCA complex, which contains BRCA1, PALB2, BRCA2 and RAD51. Interacts with PALB2. Forms a complex with MSL1 and NUPR1.
    SequenceCaution:
    • Sequence=AAG17253.1; Type=Frameshift; Positions=348, 360; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MORF4L1 Gene

    Alternative splice isoforms for MORF4L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MORF4L1 Gene

Post-translational modifications for MORF4L1 Gene

  • Ubiquitination at Lys51, isoforms=2, 3339, isoforms=2, 3249, Lys240, isoforms=2, 3226, Lys218, Lys198, isoforms=2, 3143, isoforms=2127, isoforms=2117, Lys111, and Lys103
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MORF4L1 Gene

Domains & Families for MORF4L1 Gene

Gene Families for MORF4L1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MORF4L1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MORF4L1: view

No data available for UniProtKB/Swiss-Prot for MORF4L1 Gene

Function for MORF4L1 Gene

Molecular function for MORF4L1 Gene

UniProtKB/Swiss-Prot Function:
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.

Phenotypes From GWAS Catalog for MORF4L1 Gene

Gene Ontology (GO) - Molecular Function for MORF4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 12963728
GO:0047485 protein N-terminus binding IPI 17577209
genes like me logo Genes that share ontologies with MORF4L1: view
genes like me logo Genes that share phenotypes with MORF4L1: view

Animal Models for MORF4L1 Gene

MGI Knock Outs for MORF4L1:

Animal Model Products

  • Taconic Biosciences Mouse Models for MORF4L1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MORF4L1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MORF4L1 Gene

Localization for MORF4L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MORF4L1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MORF4L1 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MORF4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IBA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0016580 Sin3 complex IDA,IEA 14966270
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with MORF4L1: view

Pathways & Interactions for MORF4L1 Gene

genes like me logo Genes that share pathways with MORF4L1: view

Pathways by source for MORF4L1 Gene

1 BioSystems pathway for MORF4L1 Gene
1 Cell Signaling Technology pathway for MORF4L1 Gene

Gene Ontology (GO) - Biological Process for MORF4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IDA 20332121
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006325 chromatin organization IEA --
GO:0006338 chromatin remodeling IBA --
genes like me logo Genes that share ontologies with MORF4L1: view

No data available for SIGNOR curated interactions for MORF4L1 Gene

Drugs & Compounds for MORF4L1 Gene

(1) Drugs for MORF4L1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MORF4L1: view

Transcripts for MORF4L1 Gene

Unigene Clusters for MORF4L1 Gene

Mortality factor 4 like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MORF4L1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MORF4L1 Gene

No ASD Table

Relevant External Links for MORF4L1 Gene

GeneLoc Exon Structure for
MORF4L1
ECgene alternative splicing isoforms for
MORF4L1

Expression for MORF4L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MORF4L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MORF4L1 Gene

This gene is overexpressed in Nasal epithelium (28.7) and Breast (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MORF4L1 Gene



Protein tissue co-expression partners for MORF4L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MORF4L1 Gene:

MORF4L1

SOURCE GeneReport for Unigene cluster for MORF4L1 Gene:

Hs.374503

Evidence on tissue expression from TISSUES for MORF4L1 Gene

  • Nervous system(5)
  • Skin(4.8)
  • Lung(4.7)
  • Intestine(4.5)
  • Kidney(4.5)
  • Blood(4.4)
  • Pancreas(3.8)
  • Eye(3.4)
  • Liver(2.7)
  • Heart(2.6)
  • Spleen(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with MORF4L1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MORF4L1 Gene

Orthologs for MORF4L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MORF4L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MORF4L1 34 33
  • 99.69 (n)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 99 (a)
OneToMany
-- 34
  • 98 (a)
OneToMany
MORF4L1 33
  • 90.99 (n)
-- 34
  • 75 (a)
OneToMany
-- 34
  • 58 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 96 (a)
ManyToMany
-- 34
  • 64 (a)
ManyToMany
-- 34
  • 59 (a)
ManyToMany
-- 34
  • 59 (a)
ManyToMany
-- 34
  • 57 (a)
ManyToMany
-- 34
  • 54 (a)
ManyToMany
-- 34
  • 51 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 20 (a)
ManyToMany
-- 34
  • 20 (a)
ManyToMany
-- 34
  • 19 (a)
ManyToMany
-- 34
  • 19 (a)
ManyToMany
-- 34
  • 18 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia MORF4L1 34
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Morf4l1 33
  • 92.16 (n)
mouse
(Mus musculus)
Mammalia Morf4l1 16 34 33
  • 91.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
ManyToMany
-- 34
  • 48 (a)
ManyToMany
chicken
(Gallus gallus)
Aves MORF4L1 34
  • 86 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 65 (a)
ManyToMany
-- 34
  • 62 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii morf4l1 34
  • 88 (a)
OneToMany
Dr.13950 33
fruit fly
(Drosophila melanogaster)
Insecta MRG15 34
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mrg-1 34 33
  • 45.66 (n)
ManyToMany
cec-7 34
  • 11 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EAF3 36 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
ManyToMany
-- 34
  • 37 (a)
ManyToMany
Species where no ortholog for MORF4L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MORF4L1 Gene

ENSEMBL:
Gene Tree for MORF4L1 (if available)
TreeFam:
Gene Tree for MORF4L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MORF4L1: view image

Paralogs for MORF4L1 Gene

Paralogs for MORF4L1 Gene

(1) SIMAP similar genes for MORF4L1 Gene using alignment to 12 proteins:

  • MO4L1_HUMAN
  • A5D8W6_HUMAN
  • B3KTM8_HUMAN
  • H0YLJ3_HUMAN
  • H0YLV1_HUMAN
  • H0YM21_HUMAN
  • H0YMJ0_HUMAN
  • H0YMT8_HUMAN
  • H0YNE0_HUMAN
  • H0YNI8_HUMAN
  • H0YNX3_HUMAN
  • Q0VAE4_HUMAN
genes like me logo Genes that share paralogs with MORF4L1: view

Variants for MORF4L1 Gene

Sequence variations from dbSNP and Humsavar for MORF4L1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000105446 -- 78,873,188(+) C/T 5_prime_UTR_variant, intron_variant
rs1000137768 -- 78,873,330(+) C/T intron_variant
rs1000294617 -- 78,896,549(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000315172 -- 78,877,245(+) C/G intron_variant
rs1000452756 -- 78,874,585(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MORF4L1 Gene

Variant ID Type Subtype PubMed ID
esv3333628 CNV insertion 20981092
esv33573 CNV gain+loss 17666407
nsv522996 CNV loss 19592680

Variation tolerance for MORF4L1 Gene

Residual Variation Intolerance Score: 29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MORF4L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MORF4L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MORF4L1 Gene

Disorders for MORF4L1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MORF4L1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
paraneoplastic cerebellar degeneration
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MORF4L1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MORF4L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MORF4L1 Gene

Publications for MORF4L1 Gene

  1. MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks. (PMID: 20332121) Hayakawa T … Andreassen PR (Journal of cell science 2010) 3 4 22 58
  2. The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14. (PMID: 17008723) Zhang P … Ding J (Protein science : a publication of the Protein Society 2006) 3 4 22 58
  3. Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain. (PMID: 16407074) Bowman BR … Quiocho FA (Structure (London, England : 1993) 2006) 3 4 22 58
  4. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PMID: 12963728) Cai Y … Conaway JW (The Journal of biological chemistry 2003) 3 4 22 58
  5. Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split. (PMID: 12391155) Yochum GS … Ayer DE (Molecular and cellular biology 2002) 3 4 22 58

Products for MORF4L1 Gene

Sources for MORF4L1 Gene

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