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Aliases for BRD8 Gene

Aliases for BRD8 Gene

  • Bromodomain Containing 8 2 3 5
  • Thyroid Hormone Receptor Coactivating Protein Of 120 KDa 3 4
  • Skeletal Muscle Abundant Protein 2 3 4
  • TrCP120 3 4
  • SMAP2 3 4
  • SMAP 3 4
  • P120 3 4
  • Bromodomain-Containing Protein 8 3
  • Skeletal Muscle Abundant Protein 4

External Ids for BRD8 Gene

Previous GeneCards Identifiers for BRD8 Gene

  • GC05M137506
  • GC05M137551
  • GC05M137503
  • GC05M137475
  • GC05M132666

Summaries for BRD8 Gene

Entrez Gene Summary for BRD8 Gene

  • The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014]

GeneCards Summary for BRD8 Gene

BRD8 (Bromodomain Containing 8) is a Protein Coding gene. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and thyroid hormone receptor activity.

UniProtKB/Swiss-Prot for BRD8 Gene

  • May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Gene Wiki entry for BRD8 Gene

Additional gene information for BRD8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRD8 Gene

Genomics for BRD8 Gene

GeneHancer (GH) Regulatory Elements for BRD8 Gene

Promoters and enhancers for BRD8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J138177 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 661.6 +0.0 46 3.1 PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 BRD8 KIF20A FAM13B HNRNPA0 CDC23 KDM3B KLHL3
GH05J138463 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 49 -286.3 -286263 4.1 CLOCK IRF4 YY1 E2F8 ZNF143 SP3 SSRP1 ZNF610 ZNF585B GLIS1 EGR1 HNRNPA0 CDC23 BRD8 KDM3B RPL7P19 ETF1 FAM13B FAM53C REEP2
GH05J138350 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 50.3 -174.3 -174349 4.7 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 SLC30A9 KDM3B CDC23 BRD8 HNRNPA0 FAM53C RPL7P19 FAM13B KIF20A GFRA3 REEP2
GH05J138540 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.8 -364.7 -364692 7 CLOCK DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 ETF1 LOC105379193 GC05P138544 CDC23 HNRNPA0 BRD8 ENSG00000232174 KDM3B WNT8A FAM53C
GH05J138335 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.6 -158.6 -158554 5 CLOCK ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 CDC25C FAM53C HNRNPA0 KDM3B CDC23 RPL7P19 REEP2 MATR3 BRD8 NME5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BRD8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BRD8 gene promoter:
  • Lmo2
  • PPAR-alpha
  • RelA
  • c-Ets-1
  • CBF-A
  • CBF(2)
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C

Genomic Locations for BRD8 Gene

Genomic Locations for BRD8 Gene
chr5:138,139,766-138,178,986
(GRCh38/hg38)
Size:
39,221 bases
Orientation:
Minus strand
chr5:137,475,455-137,514,675
(GRCh37/hg19)
Size:
39,221 bases
Orientation:
Minus strand

Genomic View for BRD8 Gene

Genes around BRD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRD8 Gene

Proteins for BRD8 Gene

  • Protein details for BRD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0E9-BRD8_HUMAN
    Recommended name:
    Bromodomain-containing protein 8
    Protein Accession:
    Q9H0E9
    Secondary Accessions:
    • O43178
    • Q15355
    • Q58AB0
    • Q59GN0
    • Q969M9

    Protein attributes for BRD8 Gene

    Size:
    1235 amino acids
    Molecular mass:
    135336 Da
    Quaternary structure:
    • Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. BRD8 isoform 2 interacts with RXRA/NR2B1 and THRB/ERBA2 (By similarity). Component of a SWR1-like complex.
    SequenceCaution:
    • Sequence=AAB87858.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH08039.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH08076.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA63925.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for BRD8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRD8 Gene

Post-translational modifications for BRD8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BRD8 Gene

Domains & Families for BRD8 Gene

Gene Families for BRD8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BRD8 Gene

Suggested Antigen Peptide Sequences for BRD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BRD8: view

No data available for UniProtKB/Swiss-Prot for BRD8 Gene

Function for BRD8 Gene

Molecular function for BRD8 Gene

UniProtKB/Swiss-Prot Function:
May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Phenotypes From GWAS Catalog for BRD8 Gene

Gene Ontology (GO) - Molecular Function for BRD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity NAS 8611617
GO:0004887 thyroid hormone receptor activity TAS 9368056
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with BRD8: view
genes like me logo Genes that share phenotypes with BRD8: view

Animal Models for BRD8 Gene

MGI Knock Outs for BRD8:
  • Brd8 Brd8<tm1a(EUCOMM)Wtsi>

Animal Model Products

miRNA for BRD8 Gene

miRTarBase miRNAs that target BRD8

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BRD8 Gene

Localization for BRD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRD8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BRD8 gene
Compartment Confidence
mitochondrion 5
nucleus 5
golgi apparatus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BRD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000812 Swr1 complex IDA 24463511
GO:0005634 nucleus NAS 8611617
GO:0005654 nucleoplasm TAS --
GO:0005739 mitochondrion IDA --
GO:0035267 NuA4 histone acetyltransferase complex IDA 14966270
genes like me logo Genes that share ontologies with BRD8: view

Pathways & Interactions for BRD8 Gene

genes like me logo Genes that share pathways with BRD8: view

Pathways by source for BRD8 Gene

Gene Ontology (GO) - Biological Process for BRD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 8611617
GO:0006357 regulation of transcription by RNA polymerase II TAS 9368056
GO:0007165 signal transduction TAS 9368056
genes like me logo Genes that share ontologies with BRD8: view

No data available for SIGNOR curated interactions for BRD8 Gene

Drugs & Compounds for BRD8 Gene

(7) Drugs for BRD8 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CPI-203 Pharma BET bromodomain inhibitor 0
I-BET151 (GSK1210151A) Pharma Selective BET inhibitor 0
MS436 Pharma BRD4 inhibitor 0
OF-1 Pharma BRPF1B and BRPF2 bromodomain inhibitor 0
PFI-1 (PF-6405761) Pharma BET inhibitor 0
genes like me logo Genes that share compounds with BRD8: view

Transcripts for BRD8 Gene

Unigene Clusters for BRD8 Gene

Bromodomain containing 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRD8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12: - - - - - - - - - - -

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c · 26d ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9: -
SP10: - - - - - - -
SP11:
SP12: - - - -

Relevant External Links for BRD8 Gene

GeneLoc Exon Structure for
BRD8
ECgene alternative splicing isoforms for
BRD8

Expression for BRD8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BRD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BRD8 Gene

This gene is overexpressed in Testis (21.6) and Peripheral blood mononuclear cells (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BRD8 Gene



Protein tissue co-expression partners for BRD8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BRD8 Gene:

BRD8

SOURCE GeneReport for Unigene cluster for BRD8 Gene:

Hs.519337

mRNA Expression by UniProt/SwissProt for BRD8 Gene:

Q9H0E9-BRD8_HUMAN
Tissue specificity: Expressed in adipose tissue, brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.

Evidence on tissue expression from TISSUES for BRD8 Gene

  • Nervous system(4.9)
  • Liver(4.3)
  • Muscle(4.3)
  • Skin(4.3)
  • Blood(4.2)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with BRD8: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BRD8 Gene

Orthologs for BRD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRD8 34 33
  • 99.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BRD8 34 33
  • 93.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia BRD8 34 33
  • 93.32 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Brd8 16 34 33
  • 90.42 (n)
rat
(Rattus norvegicus)
Mammalia Brd8 33
  • 89.33 (n)
oppossum
(Monodelphis domestica)
Mammalia BRD8 34
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRD8 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRD8 34 33
  • 75.34 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRD8 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brd8 33
  • 69.79 (n)
Str.15923 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15498 33
zebrafish
(Danio rerio)
Actinopterygii brd8 34 33
  • 58.67 (n)
OneToMany
BRD8 (2 of 2) 34
  • 47 (a)
OneToMany
Dr.9079 33
fruit fly
(Drosophila melanogaster)
Insecta Brd8 34
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9046 34
  • 42 (a)
OneToOne
Cin.14245 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14245 33
Species where no ortholog for BRD8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRD8 Gene

ENSEMBL:
Gene Tree for BRD8 (if available)
TreeFam:
Gene Tree for BRD8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BRD8: view image

Paralogs for BRD8 Gene

No data available for Paralogs for BRD8 Gene

Variants for BRD8 Gene

Sequence variations from dbSNP and Humsavar for BRD8 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000059901 -- 138,156,296(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000117998 -- 138,167,254(-) C/A intron_variant
rs1000256846 -- 138,155,999(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000341427 -- 138,159,701(-) C/T intron_variant
rs1000431641 -- 138,148,958(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BRD8 Gene

Variant ID Type Subtype PubMed ID
esv2730819 CNV deletion 23290073
esv2730820 CNV deletion 23290073
esv3566699 CNV deletion 23714750
nsv1111682 CNV deletion 24896259
nsv1121334 CNV deletion 24896259

Variation tolerance for BRD8 Gene

Residual Variation Intolerance Score: 9.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.07; 84.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BRD8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRD8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRD8 Gene

Disorders for BRD8 Gene

Additional Disease Information for BRD8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BRD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRD8 Gene

Publications for BRD8 Gene

  1. Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein. (PMID: 9368056) Monden T … Hollenberg AN (The Journal of biological chemistry 1997) 2 3 4 22 58
  2. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PMID: 12963728) Cai Y … Conaway JW (The Journal of biological chemistry 2003) 3 4 22 58
  3. Cloning and sequencing of a human cDNA encoding a putative transcription factor containing a bromodomain. (PMID: 8611617) Nielsen MS … Madsen P (Biochimica et biophysica acta 1996) 2 3 4 58
  4. ANP32E is a histone chaperone that removes H2A.Z from chromatin. (PMID: 24463511) Obri A … Hamiche A (Nature 2014) 3 4 58
  5. SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network. (PMID: 16571680) Natsume W … Satake M (Molecular biology of the cell 2006) 3 22 58

Products for BRD8 Gene

Sources for BRD8 Gene

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