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Aliases for C1QL1 Gene

Aliases for C1QL1 Gene

  • Complement C1q Like 1 2 3 5
  • C1q And Tumor Necrosis Factor-Related Protein 14 3 4
  • Complement Component 1, Q Subcomponent-Like 1 2 3
  • C1q/TNF-Related Protein 14 3 4
  • C1QRF 3 4
  • CRF 3 4
  • Complement Component 1 Q Subcomponent-Like 1 4
  • C1q-Related Factor 3
  • C1QTNF14 3
  • CTRP14 4

External Ids for C1QL1 Gene

Previous GeneCards Identifiers for C1QL1 Gene

  • GC17M043513
  • GC17M040392
  • GC17M043037
  • GC17M038803

Summaries for C1QL1 Gene

GeneCards Summary for C1QL1 Gene

C1QL1 (Complement C1q Like 1) is a Protein Coding gene. An important paralog of this gene is C1QL3.

UniProtKB/Swiss-Prot for C1QL1 Gene

  • May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).

Gene Wiki entry for C1QL1 Gene

Additional gene information for C1QL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QL1 Gene

Genomics for C1QL1 Gene

GeneHancer (GH) Regulatory Elements for C1QL1 Gene

Promoters and enhancers for C1QL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I044968 Promoter/Enhancer 1.4 Ensembl ENCODE 550.8 -0.3 -327 0.8 HDAC1 RB1 ZBTB40 RAD21 ZEB1 GLIS2 ZNF366 ZNF391 SP3 ZBTB2 C1QL1 LINC02210 FAM187A GC17P044954 GC17P044983
GH17I044971 Promoter 0.8 EPDnew 550.8 +0.2 176 0.1 FOXM1 E2F1 E2F6 EZH2 C1QL1 GC17P044954 GC17P044955
GH17I044969 Enhancer 0.6 ENCODE dbSUPER 550.8 -1.3 -1302 0.2 ZFHX2 EZH2 C1QL1 EFTUD2 GC17P044954 GC17P044983
GH17I045059 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.6 -93.5 -93470 4.9 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DCAKD PIR53442 NMT1 ENSG00000262372 ASB16-AS1 TMUB2 UBTF C17orf53 MAP3K14-AS1 LSM12
GH17I045020 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.9 -53.1 -53148 2.5 ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF207 ZNF143 ATF7 PAF1 DCAKD NMT1 C1QL1 GFAP CCDC103 EFTUD2 FAM187A KIF18B HEXIM2 ENSG00000224505
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C1QL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1QL1 gene promoter:

Genomic Locations for C1QL1 Gene

Genomic Locations for C1QL1 Gene
chr17:44,959,693-44,968,276
(GRCh38/hg38)
Size:
8,584 bases
Orientation:
Minus strand
chr17:43,037,061-43,045,644
(GRCh37/hg19)

Genomic View for C1QL1 Gene

Genes around C1QL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QL1 Gene

Proteins for C1QL1 Gene

  • Protein details for C1QL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75973-C1QRF_HUMAN
    Recommended name:
    C1q-related factor
    Protein Accession:
    O75973

    Protein attributes for C1QL1 Gene

    Size:
    258 amino acids
    Molecular mass:
    26453 Da
    Quaternary structure:
    • Interacts with ADGRB3. Forms heterooligomers with C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.

neXtProt entry for C1QL1 Gene

Post-translational modifications for C1QL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1QL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1QL1 Gene

Domains & Families for C1QL1 Gene

Gene Families for C1QL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for C1QL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1QL1: view

No data available for UniProtKB/Swiss-Prot for C1QL1 Gene

Function for C1QL1 Gene

Molecular function for C1QL1 Gene

UniProtKB/Swiss-Prot Function:
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).

Phenotypes From GWAS Catalog for C1QL1 Gene

Gene Ontology (GO) - Molecular Function for C1QL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IPI 19666007
genes like me logo Genes that share ontologies with C1QL1: view
genes like me logo Genes that share phenotypes with C1QL1: view

Animal Models for C1QL1 Gene

MGI Knock Outs for C1QL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QL1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for C1QL1 Gene

Localization for C1QL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QL1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for C1QL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
GO:0005737 cytoplasm IEA --
GO:0043083 synaptic cleft IEA --
genes like me logo Genes that share ontologies with C1QL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C1QL1 Gene

Pathways & Interactions for C1QL1 Gene

SuperPathways for C1QL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1QL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007626 locomotory behavior NAS 9878755
GO:0016322 neuron remodeling IEA --
GO:0061743 motor learning IEA --
GO:0099558 maintenance of synapse structure IEA --
genes like me logo Genes that share ontologies with C1QL1: view

No data available for Pathways by source and SIGNOR curated interactions for C1QL1 Gene

Drugs & Compounds for C1QL1 Gene

No Compound Related Data Available

Transcripts for C1QL1 Gene

mRNA/cDNA for C1QL1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(113) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1QL1 Gene

Complement component 1, q subcomponent-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QL1 Gene

No ASD Table

Relevant External Links for C1QL1 Gene

GeneLoc Exon Structure for
C1QL1
ECgene alternative splicing isoforms for
C1QL1

Expression for C1QL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1QL1 Gene

mRNA differential expression in normal tissues according to GTEx for C1QL1 Gene

This gene is overexpressed in Brain - Amygdala (x4.3).

Protein differential expression in normal tissues from HIPED for C1QL1 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C1QL1 Gene



Protein tissue co-expression partners for C1QL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of C1QL1 Gene:

C1QL1

SOURCE GeneReport for Unigene cluster for C1QL1 Gene:

Hs.134012

mRNA Expression by UniProt/SwissProt for C1QL1 Gene:

O75973-C1QRF_HUMAN
Tissue specificity: Expressed in brainstem.

Evidence on tissue expression from TISSUES for C1QL1 Gene

  • Nervous system(3)
  • Pancreas(2.4)
genes like me logo Genes that share expression patterns with C1QL1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QL1 Gene

Orthologs for C1QL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for C1QL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1QL1 33 34
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia C1QL1 33 34
  • 94.57 (n)
oppossum
(Monodelphis domestica)
Mammalia C1QL1 34
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C1ql1 33 16 34
  • 93.41 (n)
cow
(Bos Taurus)
Mammalia C1QL1 33 34
  • 93.28 (n)
rat
(Rattus norvegicus)
Mammalia C1ql1 33
  • 92.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 8 (a)
ManyToMany
chicken
(Gallus gallus)
Aves C1QL1 34
  • 87 (a)
OneToOne
C1QL4 33
  • 82.47 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia c1ql1 33
  • 73.22 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC556064 33
  • 71.91 (n)
c1ql3b 34
  • 67 (a)
OneToMany
C1QL1 (2 of 2) 34
  • 64 (a)
OneToMany
Dr.16893 33
fruit fly
(Drosophila melanogaster)
Insecta Capr 34
  • 5 (a)
OneToMany
Species where no ortholog for C1QL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QL1 Gene

ENSEMBL:
Gene Tree for C1QL1 (if available)
TreeFam:
Gene Tree for C1QL1 (if available)

Paralogs for C1QL1 Gene

Paralogs for C1QL1 Gene

(8) SIMAP similar genes for C1QL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C1QL1: view

Variants for C1QL1 Gene

Sequence variations from dbSNP and Humsavar for C1QL1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000160920 -- 44,967,748(-) C/T coding_sequence_variant, missense_variant
rs1000236506 -- 44,960,029(-) G/A 3_prime_UTR_variant
rs1000903668 -- 44,961,340(-) C/T intron_variant
rs1001254748 -- 44,959,590(-) T/A downstream_transcript_variant
rs1001322378 -- 44,969,873(-) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C1QL1 Gene

Variant ID Type Subtype PubMed ID
nsv1070405 CNV deletion 25765185
nsv1126459 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv527788 CNV loss 19592680
nsv575101 CNV loss 21841781
nsv575102 CNV gain 21841781
nsv833457 CNV loss 17160897
nsv953902 CNV deletion 24416366

Variation tolerance for C1QL1 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1QL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QL1 Gene

Disorders for C1QL1 Gene

Additional Disease Information for C1QL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C1QL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QL1 Gene

Publications for C1QL1 Gene

  1. Cloning and characterization of CRF, a novel C1q-related factor, expressed in areas of the brain involved in motor function. (PMID: 9878755) Bérubé NG … Pereira-Smith OM (Brain research. Molecular brain research 1999) 2 3 4 22 58
  2. CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members. (PMID: 19666007) Peterson JM … Wong GW (Biochemical and biophysical research communications 2009) 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for C1QL1 Gene

Sources for C1QL1 Gene

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