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Aliases for TUBGCP2 Gene

Aliases for TUBGCP2 Gene

  • Tubulin Gamma Complex Associated Protein 2 2 3 5
  • Spindle Pole Body Protein Spc97 Homolog 3 4
  • Gamma-Ring Complex Protein 103 KDa 3 4
  • HGrip103 3 4
  • HSpc97 3 4
  • GCP-2 3 4
  • H103p 3 4
  • HGCP2 3 4
  • GCP2 3 4
  • Tubulin, Gamma Complex Associated Protein 2 2
  • Gamma-Tubulin Complex Component 2 3
  • Grip103 3
  • SPBC97 3
  • Spc97p 3
  • SPC97 3
  • ALP4 3

External Ids for TUBGCP2 Gene

Previous GeneCards Identifiers for TUBGCP2 Gene

  • GC10M134007
  • GC10M134223
  • GC10M135009
  • GC10M134566
  • GC10M134982
  • GC10M134943
  • GC10M135094
  • GC10M128639

Summaries for TUBGCP2 Gene

GeneCards Summary for TUBGCP2 Gene

TUBGCP2 (Tubulin Gamma Complex Associated Protein 2) is a Protein Coding gene. Diseases associated with TUBGCP2 include Cardiomyopathy, Dilated, 1P. Among its related pathways are Cell Cycle, Mitotic and Regulation of PLK1 Activity at G2/M Transition. An important paralog of this gene is TUBGCP6.

UniProtKB/Swiss-Prot for TUBGCP2 Gene

  • Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Gene Wiki entry for TUBGCP2 Gene

Additional gene information for TUBGCP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBGCP2 Gene

Genomics for TUBGCP2 Gene

GeneHancer (GH) Regulatory Elements for TUBGCP2 Gene

Promoters and enhancers for TUBGCP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J133304 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 662.1 +4.9 4853 5.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B E2F8 TUBGCP2 ZNF511 ZNF511-PRAP1 ECHS1 VENTX ADAM8 GC10P133300
GH10J133313 Enhancer 0.8 Ensembl 650.7 -1.7 -1660 0.4 ATF1 KLF17 ZNF2 RAD21 ZEB1 ZNF143 ATF7 CREM SMARCA5 ZNF654 TUBGCP2 ZNF511-PRAP1 GC10M133326
GH10J133311 Promoter 0.5 EPDnew 650.7 +0.6 615 0.1 ZNF511 TUBGCP2 ZNF511-PRAP1
GH10J133310 Enhancer 0.4 ENCODE 650.7 +2.0 1975 0.1 POLR2A SCRT2 GABPA ZNF511 ZNF511-PRAP1 TUBGCP2
GH10J132392 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 81.7 +903.9 903935 32.2 HDGF PKNOX1 CLOCK SMAD1 ARID4B NEUROD1 SIN3A YBX1 DMAP1 ZBTB7B PWWP2B TUBGCP2 ENSG00000235245 C10orf91 ZNF511 STK32C LOC105378568 PAOX PPP2R2D MTG1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TUBGCP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TUBGCP2 gene promoter:
  • USF1
  • STAT3
  • USF-1
  • ER-alpha
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alphaA
  • AP-2alpha isoform 4
  • RFX1

Genomic Locations for TUBGCP2 Gene

Genomic Locations for TUBGCP2 Gene
33,708 bases
Minus strand
32,707 bases
Minus strand

Genomic View for TUBGCP2 Gene

Genes around TUBGCP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBGCP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBGCP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBGCP2 Gene

Proteins for TUBGCP2 Gene

  • Protein details for TUBGCP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gamma-tubulin complex component 2
    Protein Accession:
    Secondary Accessions:
    • B4DM18
    • B7ZKL8
    • F5H4E0
    • F5H4L0
    • O43632
    • Q5VWX7

    Protein attributes for TUBGCP2 Gene

    902 amino acids
    Molecular mass:
    102534 Da
    Quaternary structure:
    • Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome (PubMed:26213385).
    • Sequence=BC005011; Type=Frameshift; Positions=513; Evidence={ECO:0000305};

    Alternative splice isoforms for TUBGCP2 Gene


neXtProt entry for TUBGCP2 Gene

Post-translational modifications for TUBGCP2 Gene

  • Ubiquitination at isoforms=3, 4455 and posLast=157157
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TUBGCP2 Gene

Domains & Families for TUBGCP2 Gene

Gene Families for TUBGCP2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TUBGCP2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TUBGCP family.
  • Belongs to the TUBGCP family.
genes like me logo Genes that share domains with TUBGCP2: view

Function for TUBGCP2 Gene

Molecular function for TUBGCP2 Gene

UniProtKB/Swiss-Prot Function:
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Phenotypes From GWAS Catalog for TUBGCP2 Gene

Gene Ontology (GO) - Molecular Function for TUBGCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IBA --
GO:0005515 protein binding IPI 16980960
GO:0043015 gamma-tubulin binding IBA --
GO:0051011 contributes_to microtubule minus-end binding IBA --
genes like me logo Genes that share ontologies with TUBGCP2: view
genes like me logo Genes that share phenotypes with TUBGCP2: view

Animal Model Products

miRNA for TUBGCP2 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBGCP2 Gene

Localization for TUBGCP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBGCP2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUBGCP2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TUBGCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0000923 equatorial microtubule organizing center IBA --
GO:0000930 gamma-tubulin complex IBA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TUBGCP2: view

Pathways & Interactions for TUBGCP2 Gene

genes like me logo Genes that share pathways with TUBGCP2: view

Gene Ontology (GO) - Biological Process for TUBGCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007020 microtubule nucleation TAS 9566967
GO:0031122 cytoplasmic microtubule organization IBA --
GO:0051298 centrosome duplication IBA --
GO:0051321 meiotic cell cycle IBA --
GO:0051415 microtubule nucleation by interphase microtubule organizing center IBA --
genes like me logo Genes that share ontologies with TUBGCP2: view

No data available for SIGNOR curated interactions for TUBGCP2 Gene

Drugs & Compounds for TUBGCP2 Gene

(1) Drugs for TUBGCP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TUBGCP2: view

Transcripts for TUBGCP2 Gene

mRNA/cDNA for TUBGCP2 Gene

Unigene Clusters for TUBGCP2 Gene

Tubulin, gamma complex associated protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBGCP2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a ·
SP1: - - - - - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: -
SP11: - - - - -
SP12: - - -
SP17: - -
SP18: - - -
SP19: -

ExUns: 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b
SP1: - - - - - - -
SP2: - - - -
SP8: - - -
SP10: -
SP13: -
SP14: - -
SP15: -

Relevant External Links for TUBGCP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TUBGCP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TUBGCP2 Gene

Protein differential expression in normal tissues from HIPED for TUBGCP2 Gene

This gene is overexpressed in Bone (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TUBGCP2 Gene

Protein tissue co-expression partners for TUBGCP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TUBGCP2 Gene:


SOURCE GeneReport for Unigene cluster for TUBGCP2 Gene:


mRNA Expression by UniProt/SwissProt for TUBGCP2 Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for TUBGCP2 Gene

  • Nervous system(4.8)
  • Pancreas(4.4)
  • Eye(2.2)
  • Kidney(2.2)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with TUBGCP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBGCP2 Gene

Orthologs for TUBGCP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBGCP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TUBGCP2 34 33
  • 96.02 (n)
(Canis familiaris)
Mammalia TUBGCP2 34 33
  • 87.23 (n)
(Mus musculus)
Mammalia Tubgcp2 16 34 33
  • 86.4 (n)
(Rattus norvegicus)
Mammalia Tubgcp2 33
  • 86.36 (n)
(Ornithorhynchus anatinus)
Mammalia TUBGCP2 34
  • 86 (a)
(Bos Taurus)
Mammalia TUBGCP2 34 33
  • 85.74 (n)
(Monodelphis domestica)
Mammalia TUBGCP2 34
  • 73 (a)
(Gallus gallus)
Aves TUBGCP2 34 33
  • 76.29 (n)
(Anolis carolinensis)
Reptilia TUBGCP2 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tubgcp2 33
  • 71.38 (n)
(Danio rerio)
Actinopterygii tubgcp2 34 33
  • 73.37 (n)
-- 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005575 33
  • 54.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta Grip84 34 33
  • 53.15 (n)
CG7716 34
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPC98 34
  • 13 (a)
SPC97 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G17410 33
  • 47.39 (n)
(Oryza sativa)
Liliopsida Os04g0501700 33
  • 46.45 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3710 34
  • 46 (a)
Species where no ortholog for TUBGCP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUBGCP2 Gene

Gene Tree for TUBGCP2 (if available)
Gene Tree for TUBGCP2 (if available)
Evolutionary constrained regions (ECRs) for TUBGCP2: view image

Paralogs for TUBGCP2 Gene

Paralogs for TUBGCP2 Gene

genes like me logo Genes that share paralogs with TUBGCP2: view

Variants for TUBGCP2 Gene

Sequence variations from dbSNP and Humsavar for TUBGCP2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000047859 -- 133,296,540(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000159270 -- 133,306,501(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000171726 -- 133,279,271(-) T/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000224788 -- 133,287,913(-) A/C intron_variant
rs1000272386 -- 133,301,358(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TUBGCP2 Gene

Variant ID Type Subtype PubMed ID
dgv122n27 CNV loss 19166990
dgv1475n54 CNV loss 21841781
dgv1476n54 CNV gain 21841781
dgv1477n54 CNV gain+loss 21841781
dgv1478n54 CNV gain+loss 21841781
dgv1479n54 CNV loss 21841781
dgv1480n54 CNV gain 21841781
dgv1481n54 CNV loss 21841781
dgv2e196 CNV duplication 17116639
dgv3e196 CNV duplication 17116639
esv23338 CNV gain+loss 19812545
esv2536519 CNV deletion 19546169
esv2750853 CNV gain 17911159
esv2759793 CNV gain+loss 17122850
esv2760107 CNV gain 21179565
esv2894 CNV loss 18987735
esv3547149 CNV deletion 23714750
esv3625030 CNV gain 21293372
esv3625039 CNV loss 21293372
esv3625040 CNV gain 21293372
esv3891901 CNV loss 25118596
esv7552 CNV loss 19470904
esv988628 CNV insertion 20482838
nsv1037772 CNV gain 25217958
nsv1040726 CNV loss 25217958
nsv1052904 CNV gain 25217958
nsv1069102 CNV deletion 25765185
nsv1076103 CNV deletion 25765185
nsv1113353 CNV deletion 24896259
nsv1147942 CNV deletion 26484159
nsv1159785 CNV deletion 26073780
nsv1159786 CNV deletion 26073780
nsv428243 CNV gain 18775914
nsv470980 CNV loss 18288195
nsv509381 CNV insertion 20534489
nsv512195 CNV loss 21212237
nsv528260 CNV loss 19592680
nsv552587 CNV loss 21841781
nsv552589 CNV gain 21841781
nsv552590 CNV loss 21841781
nsv552599 CNV loss 21841781
nsv552615 CNV gain+loss 21841781
nsv552616 CNV gain 21841781
nsv552617 CNV loss 21841781
nsv552618 CNV gain 21841781
nsv552621 CNV loss 21841781
nsv552622 CNV loss 21841781
nsv552623 CNV loss 21841781
nsv819663 CNV loss 19587683
nsv832036 CNV loss 17160897
nsv832038 CNV gain+loss 17160897
nsv832040 CNV loss 17160897
nsv952705 CNV deletion 24416366

Variation tolerance for TUBGCP2 Gene

Residual Variation Intolerance Score: 24.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TUBGCP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBGCP2 Gene

Disorders for TUBGCP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TUBGCP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cardiomyopathy, dilated, 1p
  • cmd1p
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TUBGCP2

genes like me logo Genes that share disorders with TUBGCP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUBGCP2 Gene

Publications for TUBGCP2 Gene

  1. The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p. (PMID: 9566967) Murphy SM … Stearns T (The Journal of cell biology 1998) 2 3 4 22 58
  2. ATF5 Connects the Pericentriolar Materials to the Proximal End of the Mother Centriole. (PMID: 26213385) Madarampalli B … Liu DX (Cell 2015) 3 4 58
  3. Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus. (PMID: 19299467) Fant X … Merdes A (Journal of cell science 2009) 3 22 58
  4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for TUBGCP2 Gene

Sources for TUBGCP2 Gene

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