Aliases for ZMYND11 Gene
External Ids for ZMYND11 Gene
Previous GeneCards Identifiers for ZMYND11 Gene
The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZMYND11 Gene
ZMYND11 (Zinc Finger MYND-Type Containing 11) is a Protein Coding gene. Diseases associated with ZMYND11 include Mental Retardation, Autosomal Dominant 30 and Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome. Among its related pathways are Toll-like Receptor Signaling Pathway. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity and methylated histone binding. An important paralog of this gene is ZMYND8.
UniProtKB/Swiss-Prot for ZMYND11 Gene
Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at Lys-36 (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.
(Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction.