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Aliases for OGA Gene

Aliases for OGA Gene

  • O-GlcNAcase 2 3
  • Nuclear Cytoplasmic O-GlcNAcase And Acetyltransferase 2 3 4
  • Meningioma Expressed Antigen 5 (Hyaluronidase) 2 3 5
  • N-Acetyl-Beta-D-Glucosaminidase 3 4
  • Meningioma-Expressed Antigen 5 3 4
  • N-Acetyl-Beta-Glucosaminidase 3 4
  • Beta-N-Acetylglucosaminidase 3 4
  • Beta-N-Acetylhexosaminidase 3 4
  • Beta-Hexosaminidase 3 4
  • MGEA5 3 5
  • NCOAT 3 4
  • MEA5 3 4
  • Hyaluronidase In Meningioma 3
  • Bifunctional Protein NCOAT 3
  • Protein O-GlcNAcase 3
  • EC 3.2.1.169 4
  • KIAA0679 4
  • HEXC 4

External Ids for OGA Gene

Previous HGNC Symbols for OGA Gene

  • MGEA5

Summaries for OGA Gene

Entrez Gene Summary for OGA Gene

  • The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]

GeneCards Summary for OGA Gene

OGA (O-GlcNAcase) is a Protein Coding gene. Diseases associated with OGA include Gm2-Gangliosidosis, Ab Variant and Diabetes Mellitus, Insulin-Dependent, 24. Among its related pathways are Insulin resistance.

UniProtKB/Swiss-Prot for OGA Gene

  • Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).

  • Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.

Gene Wiki entry for OGA Gene

Additional gene information for OGA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGA Gene

Genomics for OGA Gene

GeneHancer (GH) Regulatory Elements for OGA Gene

Promoters and enhancers for OGA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J101814 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.6 1600 5.9 CLOCK MLX FEZF1 YY1 ZNF213 ZNF143 SP3 SSRP1 GLIS1 NBN OGA KCNIP2-AS1 PPRC1 HPS6 LDB1 GBF1 MRPL43 TWNK SUFU NPM3
GH10J102054 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.7 -236.9 -236929 2.5 HDGF CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ARMH3 OGA LDB1 PPRC1 NOLC1 SUFU KCNIP2 ENSG00000222430
GH10J102710 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 11.3 -894.3 -894309 5.6 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ARL3 SFXN2 LDB1 PPRC1 HPS6 GBF1 PDCD11 OGA KCNIP2-AS1 WBP1L
GH10J102131 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.2 -314.9 -314857 3.5 CLOCK MLX ZFP64 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PPRC1 NOLC1 HPS6 SFXN2 OGA ARL3 KCNIP2-AS1 BORCS7 PIR37499 GC10M102134
GH10J101692 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 11.9 +124.4 124362 3.1 HDGF ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 SP3 SP5 FBXW4 PPRC1 GBF1 MRPL43 LDB1 ENSG00000272572 HPS6 OGA TWNK SLF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OGA on UCSC Golden Path with GeneCards custom track

Genomic Locations for OGA Gene

Genomic Locations for OGA Gene
chr10:101,784,443-101,818,709
(GRCh38/hg38)
Size:
34,267 bases
Orientation:
Minus strand
chr10:103,544,200-103,578,696
(GRCh37/hg19)
Size:
34,497 bases
Orientation:
Minus strand

Genomic View for OGA Gene

Genes around OGA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OGA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OGA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGA Gene

Proteins for OGA Gene

  • Protein details for OGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60502-OGA_HUMAN
    Recommended name:
    Protein O-GlcNAcase
    Protein Accession:
    O60502
    Secondary Accessions:
    • B7WPB9
    • D3DR79
    • E9PGF9
    • O75166
    • Q86WV0
    • Q8IV98
    • Q9BVA5
    • Q9HAR0

    Protein attributes for OGA Gene

    Size:
    916 amino acids
    Molecular mass:
    102915 Da
    Quaternary structure:
    • Monomer (PubMed:11788610). Interacts with CLOCK (By similarity).
    SequenceCaution:
    • Sequence=AAH47877.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA31654.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OGA Gene

    Alternative splice isoforms for OGA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OGA Gene

Post-translational modifications for OGA Gene

  • Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OGA Gene

Domains & Families for OGA Gene

Gene Families for OGA Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for OGA Gene

Graphical View of Domain Structure for InterPro Entry

O60502

UniProtKB/Swiss-Prot:

OGA_HUMAN :
  • Belongs to the glycosyl hydrolase 84 family.
Family:
  • Belongs to the glycosyl hydrolase 84 family.
genes like me logo Genes that share domains with OGA: view

Function for OGA Gene

Molecular function for OGA Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).
UniProtKB/Swiss-Prot Function:
Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.
UniProtKB/Swiss-Prot CatalyticActivity:
[Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H(2)O = [protein]-L-serine + N-acetyl-D-glucosamine.
UniProtKB/Swiss-Prot CatalyticActivity:
[Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H(2)O = [protein]-L-threonine + N-acetyl-D-glucosamine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-acetylglucosamine and not N-acetylgalactosamine.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.1 mM for pNP-GlcNAc {ECO:0000269 PubMed:11788610}; Vmax=652 umol/min/mg enzyme with pNP-GLcNAc as substrate {ECO:0000269 PubMed:11788610}; pH dependence: Optimum pH is 5.7-7. {ECO:0000269 PubMed:11148210};

Enzyme Numbers (IUBMB) for OGA Gene

Phenotypes From GWAS Catalog for OGA Gene

Gene Ontology (GO) - Molecular Function for OGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004415 hyalurononglucosaminidase activity TAS 9811929
GO:0016231 beta-N-acetylglucosaminidase activity IDA 11148210
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
GO:0102166 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity IEA --
genes like me logo Genes that share ontologies with OGA: view
genes like me logo Genes that share phenotypes with OGA: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OGA Gene

Localization for OGA Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGA Gene

Isoform 3: Nucleus.
Isoform 1: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OGA gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 3
lysosome 3
extracellular 2
mitochondrion 2
endosome 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for OGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 11148210
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with OGA: view

Pathways & Interactions for OGA Gene

genes like me logo Genes that share pathways with OGA: view

Pathways by source for OGA Gene

1 BioSystems pathway for OGA Gene
1 KEGG pathway for OGA Gene

Gene Ontology (GO) - Biological Process for OGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006044 N-acetylglucosamine metabolic process IDA 11148210
GO:0006493 protein O-linked glycosylation NAS 26363795
GO:0006516 glycoprotein catabolic process TAS 9811929
GO:0006517 protein deglycosylation IDA 11148210
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with OGA: view

No data available for SIGNOR curated interactions for OGA Gene

Drugs & Compounds for OGA Gene

(7) Drugs for OGA Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Streptozocin Approved, Investigational Pharma Target Antibiotic and antitumor agent 11
Water Approved Pharma 0
N-Acetyl-D-glucosamine Approved, Investigational Nutra 0
Coenzyme A Investigational Nutra 0
(Z)-Pugnac Pharma Inhibitor of O-GlcNAcase and β-hexosaminidase 0

(1) Additional Compounds for OGA Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • AcCoA
  • Acetyl coenzyme A
  • S-Acetyl-CoA
  • S-Acetyl-coenzyme A
  • Ac-CoA
72-89-9
genes like me logo Genes that share compounds with OGA: view

Transcripts for OGA Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OGA Gene

No ASD Table

Relevant External Links for OGA Gene

GeneLoc Exon Structure for
OGA
ECgene alternative splicing isoforms for
OGA

Expression for OGA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of OGA Gene:

OGA

mRNA Expression by UniProt/SwissProt for OGA Gene:

O60502-OGA_HUMAN
Tissue specificity: Ubiquitous. Shows highest expression in the brain, placenta and pancreas.

Evidence on tissue expression from TISSUES for OGA Gene

  • Nervous system(5)
  • Eye(4.6)
  • Skin(4.6)
  • Stomach(4.6)
  • Lung(4.1)
  • Kidney(4)
  • Intestine(3.5)
  • Urine(3.5)
  • Blood(3)
  • Heart(2.9)
  • Liver(2.8)
  • Spleen(2.7)
  • Bone marrow(2.6)
  • Muscle(2.6)
genes like me logo Genes that share expression patterns with OGA: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OGA Gene

Orthologs for OGA Gene

This gene was present in the common ancestor of animals.

Orthologs for OGA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGEA5 34 33
  • 99.71 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 97 (a)
OneToMany
-- 34
  • 91 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MGEA5 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGEA5 34 33
  • 94.98 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MGEA5 34 33
  • 94.43 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgea5 33
  • 91.01 (n)
mouse
(Mus musculus)
Mammalia Mgea5 16 34 33
  • 90.83 (n)
chicken
(Gallus gallus)
Aves MGEA5 34 33
  • 81.21 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGEA5 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mgea5 33
  • 74.4 (n)
Str.17607 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.17870 33
zebrafish
(Danio rerio)
Actinopterygii mgea5 34 33
  • 74.44 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Oga 34 33
  • 52.81 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002287 33
  • 52.42 (n)
worm
(Caenorhabditis elegans)
Secernentea oga-1 34 33
  • 45.28 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToOne
Species where no ortholog for OGA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OGA Gene

ENSEMBL:
Gene Tree for OGA (if available)
TreeFam:
Gene Tree for OGA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OGA: view image

Paralogs for OGA Gene

No data available for Paralogs for OGA Gene

Variants for OGA Gene

Sequence variations from dbSNP and Humsavar for OGA Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000059290 -- 101,817,285(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000224430 -- 101,804,565(-) G/A intron_variant
rs1000234527 -- 101,810,934(-) G/A intron_variant
rs1000349212 -- 101,798,596(-) T/C intron_variant
rs1000403832 -- 101,810,630(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OGA Gene

Variant ID Type Subtype PubMed ID
dgv171n67 CNV gain 20364138
esv1006576 CNV deletion 20482838

Variation tolerance for OGA Gene

Residual Variation Intolerance Score: 9.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OGA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OGA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGA Gene

Disorders for OGA Gene

MalaCards: The human disease database

(7) MalaCards diseases for OGA Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
gm2-gangliosidosis, ab variant
  • hexosaminidase activator deficiency
diabetes mellitus, insulin-dependent, 24
  • iddm24
urinary system disease
  • non-neoplastic urinary tract disease
meningioma, familial
  • meningioma, familial, susceptibility to
renal tuberculosis
  • tuberculosis of kidney
- elite association - COSMIC cancer census association via MalaCards
Search OGA in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with OGA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OGA Gene

Publications for OGA Gene

  1. Novel immunogenic antigen homologous to hyaluronidase in meningioma. (PMID: 9811929) Heckel D … Meese E (Human molecular genetics 1998) 2 3 4 22 58
  2. Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase. (PMID: 11341771) Comtesse N … Meese E (Biochemical and biophysical research communications 2001) 3 4 22 58
  3. Human OGA binds substrates in a conserved peptide recognition groove. (PMID: 20863279) Schimpl M … van Aalten DM (The Biochemical journal 2010) 3 4 58
  4. Isoforms of human O-GlcNAcase show distinct catalytic efficiencies. (PMID: 20673219) Li J … Wang P (Biochemistry. Biokhimiia 2010) 3 4 58
  5. The histone acetyltransferase NCOAT contains a zinc finger-like motif involved in substrate recognition. (PMID: 16356930) Toleman CA … Kudlow JE (The Journal of biological chemistry 2006) 2 3 58

Products for OGA Gene

Sources for OGA Gene

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