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Aliases for EXOC5 Gene

Aliases for EXOC5 Gene

  • Exocyst Complex Component 5 2 3 3 5
  • Exocyst Complex Component Sec10 3 4
  • SEC10L1 3 4
  • SEC10 3 4
  • SEC10 (S. Cerevisiae)-Like 1 2
  • SEC10-Like 1 (S. Cerevisiae) 2
  • SEC10-Like 1 3
  • PRO1912 3
  • HSEC10 3
  • SEC10P 3
  • HSec10 4

External Ids for EXOC5 Gene

Previous HGNC Symbols for EXOC5 Gene

  • SEC10L1

Previous GeneCards Identifiers for EXOC5 Gene

  • GC14M056740
  • GC14M057669
  • GC14M037833

Summaries for EXOC5 Gene

Entrez Gene Summary for EXOC5 Gene

  • The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]

GeneCards Summary for EXOC5 Gene

EXOC5 (Exocyst Complex Component 5) is a Protein Coding gene. Diseases associated with EXOC5 include Bardet-Biedl Syndrome 18. Among its related pathways are Organelle biogenesis and maintenance and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding and Ral GTPase binding.

UniProtKB/Swiss-Prot for EXOC5 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Wiki entry for EXOC5 Gene

Additional gene information for EXOC5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC5 Gene

Genomics for EXOC5 Gene

GeneHancer (GH) Regulatory Elements for EXOC5 Gene

Promoters and enhancers for EXOC5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J057264 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +1.4 1434 6.1 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 E2F8 AP5M1 EXOC5 NAA30 ENSG00000258592
GH14J057290 Enhancer 0.7 UCNEbase ENCODE 11.7 -21.7 -21672 1.1 EZH2 EXOC5 AP5M1 GC14P057307 PIR52540 GC14P057276
GH14J057382 Enhancer 0.7 Ensembl ENCODE 9.7 -113.5 -113493 0.6 FOSL1 ZNF146 JUND ZNF3 JUN USF2 FOS EXOC5 AP5M1 NAA30 ENSG00000259008
GH14J057383 Enhancer 0.3 Ensembl 9.7 -114.3 -114293 0.2 TCF7 AP5M1 EXOC5 NAA30 ENSG00000259008
GH14J057760 Enhancer 0.2 FANTOM5 1.6 -491.5 -491452 0.4 SLC35F4 NAA30 ACTR10 EXOC5 ARMH4 RN7SKP99 GC14M057656
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EXOC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EXOC5 gene promoter:
  • POU2F1a
  • POU2F1
  • AML1a
  • Meis-1
  • Meis-1a
  • Meis-1b
  • LUN-1
  • Pax-5

Genomic Locations for EXOC5 Gene

Genomic Locations for EXOC5 Gene
68,502 bases
Minus strand
66,533 bases
Minus strand

Genomic View for EXOC5 Gene

Genes around EXOC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC5 Gene

Proteins for EXOC5 Gene

  • Protein details for EXOC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Exocyst complex component 5
    Protein Accession:
    Secondary Accessions:
    • B2R6C5
    • Q8IW24

    Protein attributes for EXOC5 Gene

    708 amino acids
    Molecular mass:
    81853 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with EXOC3L1 (By similarity).

neXtProt entry for EXOC5 Gene

Post-translational modifications for EXOC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EXOC5 Gene

Antibody Products

  • Boster Bio Antibodies for EXOC5
  • Santa Cruz Biotechnology (SCBT) Antibodies for EXOC5

No data available for DME Specific Peptides for EXOC5 Gene

Domains & Families for EXOC5 Gene

Gene Families for EXOC5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for EXOC5 Gene

Suggested Antigen Peptide Sequences for EXOC5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SEC10 family.
  • Belongs to the SEC10 family.
genes like me logo Genes that share domains with EXOC5: view

Function for EXOC5 Gene

Molecular function for EXOC5 Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Phenotypes From GWAS Catalog for EXOC5 Gene

Gene Ontology (GO) - Molecular Function for EXOC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0017160 Ral GTPase binding IPI 24056301
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with EXOC5: view
genes like me logo Genes that share phenotypes with EXOC5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for EXOC5

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EXOC5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOC5 Gene

Localization for EXOC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOC5 Gene

Cytoplasm. Midbody. Note=Localization at the midbody requires the presence of RALA, EXOC2 and EXOC3. {ECO:0000269 PubMed:18756269}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EXOC5 gene
Compartment Confidence
cytosol 5
plasma membrane 2
mitochondrion 2
nucleus 2
golgi apparatus 1
endosome 1

Gene Ontology (GO) - Cellular Components for EXOC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IBA --
GO:0005737 cytoplasm IEA,TAS 9119050
GO:0005829 cytosol IEA,TAS --
GO:0030496 midbody IEA --
genes like me logo Genes that share ontologies with EXOC5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EXOC5 Gene

Pathways & Interactions for EXOC5 Gene

genes like me logo Genes that share pathways with EXOC5: view

Pathways by source for EXOC5 Gene

Gene Ontology (GO) - Biological Process for EXOC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA,IBA --
GO:0006892 post-Golgi vesicle-mediated transport TAS 9119050
GO:0006893 Golgi to plasma membrane transport IBA --
GO:0015031 protein transport IEA --
GO:0048278 vesicle docking IEA --
genes like me logo Genes that share ontologies with EXOC5: view

No data available for SIGNOR curated interactions for EXOC5 Gene

Drugs & Compounds for EXOC5 Gene

No Compound Related Data Available

Transcripts for EXOC5 Gene

mRNA/cDNA for EXOC5 Gene

Unigene Clusters for EXOC5 Gene

Exocyst complex component 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EXOC5

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2: - -

Relevant External Links for EXOC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EXOC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EXOC5 Gene

Protein differential expression in normal tissues from HIPED for EXOC5 Gene

This gene is overexpressed in Bone (48.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EXOC5 Gene

Protein tissue co-expression partners for EXOC5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EXOC5 Gene:


SOURCE GeneReport for Unigene cluster for EXOC5 Gene:


mRNA Expression by UniProt/SwissProt for EXOC5 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for EXOC5 Gene

  • Nervous system(4.8)
  • Eye(2.8)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with EXOC5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOC5 Gene

Orthologs for EXOC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EXOC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EXOC5 34 33
  • 99.2 (n)
(Ornithorhynchus anatinus)
Mammalia EXOC5 34
  • 97 (a)
(Canis familiaris)
Mammalia EXOC5 34 33
  • 95.39 (n)
(Monodelphis domestica)
Mammalia EXOC5 34
  • 95 (a)
(Bos Taurus)
Mammalia EXOC5 34 33
  • 94.92 (n)
(Mus musculus)
Mammalia Exoc5 16 34 33
  • 92.23 (n)
(Rattus norvegicus)
Mammalia Exoc5 33
  • 91.53 (n)
(Gallus gallus)
Aves EXOC5 34 33
  • 84.96 (n)
(Anolis carolinensis)
Reptilia EXOC5 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc5 33
  • 79.43 (n)
Str.1996 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6619 33
(Danio rerio)
Actinopterygii exoc5 34 33
  • 72.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta sec10 34 33
  • 51.87 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004147 33
  • 51.04 (n)
(Caenorhabditis elegans)
Secernentea sec-10 34 33
  • 50.36 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC10 36 34 33
  • 44.89 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18260g 33
  • 42.49 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL130C 33
  • 42.15 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SEC10 33
  • 42.12 (n)
(Oryza sativa)
Liliopsida Os12g0238100 33
  • 43.01 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2378 34
  • 48 (a)
Cin.5751 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec10 33
  • 39.38 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09313 33
  • 38.74 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5751 33
Species where no ortholog for EXOC5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC5 Gene

Gene Tree for EXOC5 (if available)
Gene Tree for EXOC5 (if available)
Evolutionary constrained regions (ECRs) for EXOC5: view image

Paralogs for EXOC5 Gene

(1) SIMAP similar genes for EXOC5 Gene using alignment to 5 proteins:

  • F8W9B8_HUMAN
  • G3V377_HUMAN
  • G3V4Z7_HUMAN
  • Q8IW24_HUMAN Pseudogenes for EXOC5 Gene

genes like me logo Genes that share paralogs with EXOC5: view

No data available for Paralogs for EXOC5 Gene

Variants for EXOC5 Gene

Sequence variations from dbSNP and Humsavar for EXOC5 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000025808 -- 57,254,849(-) T/C intron_variant
rs1000064446 -- 57,261,853(-) C/G intron_variant
rs1000090114 -- 57,213,354(-) C/T intron_variant
rs1000214942 -- 57,236,172(-) G/T intron_variant
rs1000252713 -- 57,264,409(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EXOC5 Gene

Variant ID Type Subtype PubMed ID
nsv1046422 CNV gain 25217958
nsv1138303 CNV deletion 24896259
nsv977472 CNV duplication 23825009

Variation tolerance for EXOC5 Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EXOC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC5 Gene

Disorders for EXOC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EXOC5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bardet-biedl syndrome 18
  • bbs18
- elite association - COSMIC cancer census association via MalaCards
Search EXOC5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EXOC5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with EXOC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EXOC5 Gene

Publications for EXOC5 Gene

  1. Identification and characterization of homologues of the Exocyst component Sec10p. (PMID: 9119050) Guo W … Novick P (FEBS letters 1997) 2 3 4 22 58
  2. Association between single-nucleotide polymorphisms in the SEC8L1 gene, which encodes a subunit of the exocyst complex, and rheumatoid arthritis in a Japanese population. (PMID: 15880602) Hamada D … Itakura M (Arthritis and rheumatism 2005) 3 44 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58

Products for EXOC5 Gene

Sources for EXOC5 Gene

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