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Aliases for GAS2L1 Gene

Aliases for GAS2L1 Gene

  • Growth Arrest Specific 2 Like 1 2 3 5
  • Growth Arrest-Specific Protein 2-Like 1 3 4
  • GAS2-Related Protein On Chromosome 22 3 4
  • GAR22 3 4
  • GAS2-Like Protein 1 3

External Ids for GAS2L1 Gene

Previous GeneCards Identifiers for GAS2L1 Gene

  • GC22P026399
  • GC22P028027
  • GC22P029702
  • GC22P012667

Summaries for GAS2L1 Gene

Entrez Gene Summary for GAS2L1 Gene

  • This gene encodes a member of the growth arrest-specific 2 protein family. This protein binds components of the cytoskeleton and may be involved in mediating interactions between microtubules and microfilaments. This protein localizes to the proximal end of mature centrioles and links centrosomes to both microtubules and actin. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, May 2018]

GeneCards Summary for GAS2L1 Gene

GAS2L1 (Growth Arrest Specific 2 Like 1) is a Protein Coding gene. Among its related pathways are Ectoderm Differentiation. Gene Ontology (GO) annotations related to this gene include microtubule binding and cytoskeletal adaptor activity. An important paralog of this gene is GAS2L2.

UniProtKB/Swiss-Prot for GAS2L1 Gene

  • Seems to be involved in the cross-linking of microtubules and microfilaments.

Gene Wiki entry for GAS2L1 Gene

Additional gene information for GAS2L1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS2L1 Gene

Genomics for GAS2L1 Gene

GeneHancer (GH) Regulatory Elements for GAS2L1 Gene

Promoters and enhancers for GAS2L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J029305 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 674 +2.2 2227 7.1 CLOCK ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 POLR2B GAS2L1 RASL10A AP1B1 RHBDD3 ENSG00000273216
GH22J029265 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 34.8 -38.0 -38012 6.6 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 EWSR1 RHBDD3 GAS2L1 RASL10A THOC5
GH22J029414 Enhancer 0.9 Ensembl ENCODE 19.7 +108.7 108672 1.7 HDGF HDAC1 PKNOX1 IRF2 MAX SIN3A ZBTB40 KLF5 YY1 ZNF207 LOC102723305 GAS2L1 NIPSNAP1 OSM AP1B1 MIR3653
GH22J029312 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 11.5 +8.3 8301 4.3 ZSCAN5A CTCF KLF1 USF1 ZNF777 MAX SIN3A ZIC2 RAD21 ZKSCAN1 RASL10A GAS2L1 ENSG00000237015 RHBDD3 CCDC117 ENSG00000273216
GH22J029381 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 7.1 +78.8 78822 8.1 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 AP1B1 RASL10A RPS3AP51 RPL36P17 LOC105372988 SNORD125 ZNRF3 GAS2L1 RHBDD3 LOC102723305
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAS2L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GAS2L1 gene promoter:
  • Evi-1
  • FOXL1
  • TBP
  • NF-kappaB1
  • NF-kappaB
  • Pax-5
  • FOXO4
  • POU3F1
  • MAZR
  • HFH-1

Genomic Locations for GAS2L1 Gene

Genomic Locations for GAS2L1 Gene
chr22:29,306,582-29,312,789
(GRCh38/hg38)
Size:
6,208 bases
Orientation:
Plus strand
chr22:29,702,572-29,708,774
(GRCh37/hg19)
Size:
6,203 bases
Orientation:
Plus strand

Genomic View for GAS2L1 Gene

Genes around GAS2L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAS2L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS2L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAS2L1 Gene

Proteins for GAS2L1 Gene

  • Protein details for GAS2L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99501-GA2L1_HUMAN
    Recommended name:
    GAS2-like protein 1
    Protein Accession:
    Q99501
    Secondary Accessions:
    • B5MCR7
    • Q53EN7
    • Q92640
    • Q9BUY9

    Protein attributes for GAS2L1 Gene

    Size:
    681 amino acids
    Molecular mass:
    72717 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GAS2L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAS2L1 Gene

Post-translational modifications for GAS2L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GAS2L1 Gene

Domains & Families for GAS2L1 Gene

Gene Families for GAS2L1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GAS2L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99501

UniProtKB/Swiss-Prot:

GA2L1_HUMAN :
  • Belongs to the GAS2 family.
Family:
  • Belongs to the GAS2 family.
genes like me logo Genes that share domains with GAS2L1: view

Function for GAS2L1 Gene

Molecular function for GAS2L1 Gene

UniProtKB/Swiss-Prot Function:
Seems to be involved in the cross-linking of microtubules and microfilaments.

Phenotypes From GWAS Catalog for GAS2L1 Gene

Gene Ontology (GO) - Molecular Function for GAS2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IEA --
GO:0008093 cytoskeletal adaptor activity IEA --
GO:0046966 thyroid hormone receptor binding IDA 19375645
genes like me logo Genes that share ontologies with GAS2L1: view
genes like me logo Genes that share phenotypes with GAS2L1: view

Animal Models for GAS2L1 Gene

MGI Knock Outs for GAS2L1:
  • Gas2l1 Gas2l1<tm1.1(KOMP)Vlcg>

Animal Model Products

miRNA for GAS2L1 Gene

miRTarBase miRNAs that target GAS2L1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GAS2L1 Gene

Localization for GAS2L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAS2L1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAS2L1 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GAS2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with GAS2L1: view

Pathways & Interactions for GAS2L1 Gene

SuperPathways for GAS2L1 Gene

SuperPathway Contained pathways
1 Ectoderm Differentiation
genes like me logo Genes that share pathways with GAS2L1: view

Pathways by source for GAS2L1 Gene

1 GeneTex pathway for GAS2L1 Gene
1 BioSystems pathway for GAS2L1 Gene

Interacting Proteins for GAS2L1 Gene

Gene Ontology (GO) - Biological Process for GAS2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest ISS 12584248
GO:0009267 cellular response to starvation ISS 12584248
GO:0097067 cellular response to thyroid hormone stimulus IDA 19375645
genes like me logo Genes that share ontologies with GAS2L1: view

No data available for SIGNOR curated interactions for GAS2L1 Gene

Drugs & Compounds for GAS2L1 Gene

No Compound Related Data Available

Transcripts for GAS2L1 Gene

Unigene Clusters for GAS2L1 Gene

Growth arrest-specific 2 like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAS2L1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7:
SP8: -

Relevant External Links for GAS2L1 Gene

GeneLoc Exon Structure for
GAS2L1
ECgene alternative splicing isoforms for
GAS2L1

Expression for GAS2L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAS2L1 Gene

Protein differential expression in normal tissues from HIPED for GAS2L1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (45.5) and Testis (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GAS2L1 Gene



Protein tissue co-expression partners for GAS2L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GAS2L1 Gene:

GAS2L1

SOURCE GeneReport for Unigene cluster for GAS2L1 Gene:

Hs.322852

Evidence on tissue expression from TISSUES for GAS2L1 Gene

  • Nervous system(4.7)
  • Blood(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with GAS2L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAS2L1 Gene

Orthologs for GAS2L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAS2L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GAS2L1 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GAS2L1 34 33
  • 87.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GAS2L1 34 33
  • 87.47 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gas2l1 16 34 33
  • 83.36 (n)
oppossum
(Monodelphis domestica)
Mammalia GAS2L1 34
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859584 33
  • 58.93 (n)
GAS2L1 34
  • 26 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAS2L1 34
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gas2l1 33
  • 55.14 (n)
zebrafish
(Danio rerio)
Actinopterygii GAS2L1 34
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToMany
Species where no ortholog for GAS2L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAS2L1 Gene

ENSEMBL:
Gene Tree for GAS2L1 (if available)
TreeFam:
Gene Tree for GAS2L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GAS2L1: view image

Paralogs for GAS2L1 Gene

Paralogs for GAS2L1 Gene

(2) SIMAP similar genes for GAS2L1 Gene using alignment to 6 proteins:

  • GA2L1_HUMAN
  • A0A5E8_HUMAN
  • B5MCR7_HUMAN
  • C9JFI0_HUMAN
  • C9JRR6_HUMAN
  • E7EQM6_HUMAN

Pseudogenes.org Pseudogenes for GAS2L1 Gene

genes like me logo Genes that share paralogs with GAS2L1: view

Variants for GAS2L1 Gene

Sequence variations from dbSNP and Humsavar for GAS2L1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000414742 -- 29,306,977(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000858612 -- 29,305,810(+) G/A upstream_transcript_variant
rs1001024675 -- 29,305,774(+) G/A upstream_transcript_variant
rs1001076924 -- 29,306,074(+) C/A upstream_transcript_variant
rs1001423787 -- 29,310,892(+) C/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for GAS2L1 Gene

Variant ID Type Subtype PubMed ID
nsv829154 CNV gain 20364138
nsv829155 CNV loss 20364138
nsv834171 CNV loss 17160897

Variation tolerance for GAS2L1 Gene

Residual Variation Intolerance Score: 48.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.26; 76.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAS2L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAS2L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS2L1 Gene

Disorders for GAS2L1 Gene

Additional Disease Information for GAS2L1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GAS2L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAS2L1 Gene

Publications for GAS2L1 Gene

  1. Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules. (PMID: 12584248) Goriounov D … Liem RK (Journal of cell science 2003) 2 3 4 58
  2. Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region. (PMID: 8975699) Zucman-Rossi J … Thomas G (Genomics 1996) 2 3 4 58
  3. An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia. (PMID: 20537721) Saito A … Akiyama K (Psychiatry research 2011) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Gas2, a growth arrest-specific protein, is a component of the microfilament network system. (PMID: 1607387) Brancolini C … Schneider C (The Journal of cell biology 1992) 2 3 58

Products for GAS2L1 Gene

Sources for GAS2L1 Gene

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