Aliases for TRIM3 Gene
External Ids for TRIM3 Gene
Previous HGNC Symbols for TRIM3 Gene
Previous GeneCards Identifiers for TRIM3 Gene
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRIM3 Gene
TRIM3 (Tripartite Motif Containing 3) is a Protein Coding gene. Among its related pathways are Innate Immune System and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and protein C-terminus binding. An important paralog of this gene is TRIM2.
UniProtKB/Swiss-Prot for TRIM3 Gene
Probably involved in vesicular trafficking via its association with the CART complex (PubMed:15772161). The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity).