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Aliases for PAIP1 Gene

Aliases for PAIP1 Gene

  • Poly(A) Binding Protein Interacting Protein 1 2 3 5
  • PABP-Interacting Protein 1 3 4
  • PAIP-1 3 4
  • Polyadenylate-Binding Protein-Interacting Protein 1 3
  • Poly(A)-Binding Protein-Interacting Protein 1 4
  • PABC1-Interacting Protein 1 3

External Ids for PAIP1 Gene

Previous GeneCards Identifiers for PAIP1 Gene

  • GC05M043835
  • GC05M044703
  • GC05M043571
  • GC05M043562
  • GC05M043477

Summaries for PAIP1 Gene

Entrez Gene Summary for PAIP1 Gene

  • The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PAIP1 Gene

PAIP1 (Poly(A) Binding Protein Interacting Protein 1) is a Protein Coding gene. Among its related pathways are Gene Expression and Translation Factors. Gene Ontology (GO) annotations related to this gene include RNA binding and translation activator activity.

UniProtKB/Swiss-Prot for PAIP1 Gene

  • Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.

Gene Wiki entry for PAIP1 Gene

Additional gene information for PAIP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAIP1 Gene

Genomics for PAIP1 Gene

GeneHancer (GH) Regulatory Elements for PAIP1 Gene

Promoters and enhancers for PAIP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I043554 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +1.4 1384 3.2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF143 SP3 REST SMARCB1 PAIP1 NNT C5orf34 ENSG00000249492 ENSG00000248240 EEF1A1P19 NNT-AS1 RPL29P12 FGF10-AS1 LOC153684
GH05I043033 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 +519.3 519285 10.3 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZFP41 ZNF610 ZNF585B GLIS1 NBN ANXA2R ZNF131 ENSG00000249492 TMEM267 EEF1A1P19 AMD1P3 RPL29P12 LOC153684 ENSG00000272382 PAIP1
GH05I043191 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.3 +364.6 364629 2.8 CLOCK ARID4B ZNF2 ZBTB7B FOS KLF13 SP3 NFYC REST RFX3 NIM1K ZNF131 TMEM267 EEF1A1P19 ENSG00000249492 RPL29P12 C5orf34 LOC153684 AMD1P3 PAIP1
GH05I043336 Enhancer 0.9 ENCODE 9.9 +221.3 221314 0.1 TAF9B INSM2 BATF ZNF155 CBX5 ZNF302 ATF7 FOS KLF13 SP3 ENSG00000188850 TMEM267 ZNF131 EEF1A1P19 AMD1P3 RPL29P12 ENSG00000249492 LOC153684 ENSG00000248554 ENSG00000272382
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PAIP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PAIP1 gene promoter:

Genomic Locations for PAIP1 Gene

Genomic Locations for PAIP1 Gene
chr5:43,526,267-43,557,758
(GRCh38/hg38)
Size:
31,492 bases
Orientation:
Minus strand
chr5:43,526,369-43,557,860
(GRCh37/hg19)

Genomic View for PAIP1 Gene

Genes around PAIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAIP1 Gene

Proteins for PAIP1 Gene

  • Protein details for PAIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H074-PAIP1_HUMAN
    Recommended name:
    Polyadenylate-binding protein-interacting protein 1
    Protein Accession:
    Q9H074
    Secondary Accessions:
    • A6NKV8
    • O60455
    • Q96B61
    • Q9BS63

    Protein attributes for PAIP1 Gene

    Size:
    479 amino acids
    Molecular mass:
    53525 Da
    Quaternary structure:
    • Interacts with the RRM1-RRM2 and C-terminus regions of PABPC1 in a 1:1 stoichiometry. Interacts with EIF4A.

    Three dimensional structures from OCA and Proteopedia for PAIP1 Gene

    Alternative splice isoforms for PAIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAIP1 Gene

Post-translational modifications for PAIP1 Gene

  • Ubiquitination at isoforms=2, 3368
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PAIP1 Gene

Domains & Families for PAIP1 Gene

Gene Families for PAIP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PAIP1 Gene

Suggested Antigen Peptide Sequences for PAIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H074

UniProtKB/Swiss-Prot:

PAIP1_HUMAN :
  • Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation.
Domain:
  • Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation.
genes like me logo Genes that share domains with PAIP1: view

Function for PAIP1 Gene

Molecular function for PAIP1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.

Phenotypes From GWAS Catalog for PAIP1 Gene

Gene Ontology (GO) - Molecular Function for PAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 9548260
GO:0008494 translation activator activity IDA 9548260
genes like me logo Genes that share ontologies with PAIP1: view
genes like me logo Genes that share phenotypes with PAIP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PAIP1 Gene

Localization for PAIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAIP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAIP1 gene
Compartment Confidence
cytosol 5
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9548260
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PAIP1: view

Pathways & Interactions for PAIP1 Gene

genes like me logo Genes that share pathways with PAIP1: view

Pathways by source for PAIP1 Gene

1 BioSystems pathway for PAIP1 Gene
1 KEGG pathway for PAIP1 Gene
1 Qiagen pathway for PAIP1 Gene

Gene Ontology (GO) - Biological Process for PAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006413 translational initiation TAS 9548260
GO:0006417 regulation of translation IEA --
GO:0045727 positive regulation of translation IEA --
GO:0048255 mRNA stabilization TAS 11997512
genes like me logo Genes that share ontologies with PAIP1: view

No data available for SIGNOR curated interactions for PAIP1 Gene

Drugs & Compounds for PAIP1 Gene

(2) Additional Compounds for PAIP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PAIP1: view

Transcripts for PAIP1 Gene

Unigene Clusters for PAIP1 Gene

Poly(A) binding protein interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAIP1 Gene

No ASD Table

Relevant External Links for PAIP1 Gene

GeneLoc Exon Structure for
PAIP1
ECgene alternative splicing isoforms for
PAIP1

Expression for PAIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PAIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PAIP1 Gene

This gene is overexpressed in Skin (6.6) and Heart (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PAIP1 Gene



Protein tissue co-expression partners for PAIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PAIP1 Gene:

PAIP1

SOURCE GeneReport for Unigene cluster for PAIP1 Gene:

Hs.482038

Evidence on tissue expression from TISSUES for PAIP1 Gene

  • Kidney(4.3)
  • Skin(4.1)
  • Nervous system(3)
genes like me logo Genes that share expression patterns with PAIP1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PAIP1 Gene

Orthologs for PAIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PAIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAIP1 34 33
  • 99.32 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PAIP1 33 34
  • 93.91 (n)
cow
(Bos Taurus)
Mammalia PAIP1 34 33
  • 93.79 (n)
OneToMany
-- 34
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Paip1 16 34 33
  • 92.86 (n)
rat
(Rattus norvegicus)
Mammalia Paip1 33
  • 92.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PAIP1 34
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PAIP1 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAIP1 33 34
  • 76.31 (n)
lizard
(Anolis carolinensis)
Reptilia PAIP1 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia paip1 33
  • 65.21 (n)
Str.1486 33
African clawed frog
(Xenopus laevis)
Amphibia paip1-pending-prov 33
zebrafish
(Danio rerio)
Actinopterygii paip1 33 34
  • 61.44 (n)
wufb53g01 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5680 33
fruit fly
(Drosophila melanogaster)
Insecta CG8963 33 34
  • 42.37 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011627 33
  • 41.63 (n)
Species where no ortholog for PAIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PAIP1 Gene

ENSEMBL:
Gene Tree for PAIP1 (if available)
TreeFam:
Gene Tree for PAIP1 (if available)

Paralogs for PAIP1 Gene

No data available for Paralogs for PAIP1 Gene

Variants for PAIP1 Gene

Sequence variations from dbSNP and Humsavar for PAIP1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000021506 -- 43,527,018(-) A/G 3_prime_UTR_variant
rs1000061555 -- 43,534,419(-) G/C intron_variant
rs1000124278 -- 43,541,659(-) G/T intron_variant
rs1000174906 -- 43,543,615(-) T/C intron_variant
rs1000223636 -- 43,541,315(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PAIP1 Gene

Variant ID Type Subtype PubMed ID
dgv3078n106 CNV deletion 24896259
dgv9737n54 CNV gain 21841781
dgv9738n54 CNV loss 21841781
esv2550683 CNV insertion 19546169
esv2660584 CNV deletion 23128226
esv27940 CNV loss 19812545
esv3451255 CNV duplication 20981092
esv3565872 CNV deletion 23714750
esv3604904 CNV gain 21293372
esv3604908 CNV loss 21293372
nsv512851 CNV insertion 21212237
nsv597932 CNV gain 21841781
nsv823062 CNV gain 20364138
nsv830275 CNV gain 17160897

Variation tolerance for PAIP1 Gene

Residual Variation Intolerance Score: 26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 18.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PAIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAIP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAIP1 Gene

Disorders for PAIP1 Gene

Additional Disease Information for PAIP1

No disorders were found for PAIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAIP1 Gene

Publications for PAIP1 Gene

  1. Paip1 interacts with poly(A) binding protein through two independent binding motifs. (PMID: 11997512) Roy G … Sonenberg N (Molecular and cellular biology 2002) 3 4 22 58
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  3. Translational repression by a novel partner of human poly(A) binding protein, Paip2. (PMID: 11172725) Khaleghpour K … Sonenberg N (Molecular cell 2001) 3 4 22 58
  4. A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex. (PMID: 11051545) Grosset C … Shyu AB (Cell 2000) 3 4 22 58
  5. Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. (PMID: 9548260) Craig AW … Sonenberg N (Nature 1998) 2 3 4 58

Products for PAIP1 Gene

Sources for PAIP1 Gene

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