Aliases for SLU7 Gene
External Ids for SLU7 Gene
Previous GeneCards Identifiers for SLU7 Gene
Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLU7 Gene
SLU7 (SLU7 Homolog, Splicing Factor) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Cleavage of Growing Transcript in the Termination Region. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and pre-mRNA 3-splice site binding.
UniProtKB/Swiss-Prot for SLU7 Gene
Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.